[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100603347":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":10,"id":52,"slug":53,"hasResults":54,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":10,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":65,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":37,"whyStopped":10,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},{"fullName":5,"class":6},"Peking University Shenzhen Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Preexisting Cognitive Impairment (PreCI) Group",null,"Patients aged 60 years and older with preexisting cognitive impairment undergoing elective non-cardiac surgery under general anesthesia. These patients will receive standard perioperative care without any additional intervention. Cognitive function and neuropsychiatric status will be assessed before surgery, and at 3 and 12 months after surgery to determine the incidence of postoperative cognitive decline (POCD).",[13],"Procedure: surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"Normative Population","Cognitively normal individuals recruited from inpatients and outpatients of Peking University Shenzhen Hospital. These participants will not undergo surgery but will complete the same cognitive assessments at baseline, 3 months, and 12 months. The normative data will be used to calculate the Reliable Change Index (RCI) for identifying clinically significant cognitive decline in the PreCI group.",[18],"Other: norma",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","surgery","Patients with preexisting cognitive impairment undergoing elective non-cardiac surgery under general anesthesia.",[9],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"norma","Cognitively normal individuals who do not undergo surgery but complete the same cognitive assessments at baseline, 3 months, and 12 months for normative reference.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Yaqian Yu","CONTACT","+86 13528403653","meayaqian@gmail.com",[36],{"facility":5,"status":37,"city":38,"state":39,"zip":10,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Shenzhen","Guangdong","China","CN",{"type":43,"coordinates":44},"Point",[45,46],114.0683,22.54554,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":51,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100603347","incidence-of-postoperative-cognitive-decline-in-patients-with-preexisting-cognitive-impairment-100603347",false,"NCT07135336","Incidence of Postoperative Cognitive Decline in Patients With Preexisting Cognitive Impairment","Incidence of Postoperative Cognitive Decline in Surgical Patients With Preexisting Cognitive Impairment: A Prospective Cohort Study","1. Preexisting Cognitive Impairment (PreCI) Surgical Group\n\n   Inclusion Criteria:\n   * Age ≥ 60 years\n   * Preoperative screening with MMSE and MoCA-B indicating mild cognitive impairment (MCI) or mild dementia\n   * Undergoing elective non-cardiac surgery under general anesthesia\n\n   Exclusion Criteria:\n   * Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)\n   * Usual residence outside Shenzhen\n2. Normative Reference Group\n\nInclusion Criteria:\n\n* Age ≥ 60 years\n* No history of general anesthesia surgery within the past 12 months\n* Mini-Cog score \\> 1\n\nExclusion Criteria:\n\n* Planned elective surgery under general anesthesia within the next 12 months\n* History of suspected or diagnosed cognitive impairment, or screening indicating cognitive impairment using MMSE and MoCA-B\n* Expected difficulty in completing neuropsychological assessments (e.g., inability to communicate in Mandarin, blindness, or deafness)\n* Usual residence outside Shenzhen",true,"ALL","60 Years",{"count":63,"type":64},340,"ESTIMATED","1 Year","OBSERVATIONAL","This study aims to find out how often memory and thinking problems happen after surgery in people who already have memory issues before their operation. These memory problems are called postoperative cognitive decline (POCD). Older adults with memory problems before surgery may be more likely to have trouble with thinking, memory, and daily activities after their operation. This study will follow patients who already have memory problems before surgery and see how their thinking and memory change after surgery. The results will help doctors better understand how to care for these patients before, during, and after surgery.",[69],"Cognitive and Behavioral Impairment",[71,72],"postoperative cognitive decline","preexisting cognitive impairment","2025-08-18",{"date":75,"type":76},"2025-08-22","ACTUAL",{"date":78,"type":76},"2025-07-15",{"date":80,"type":64},"2027-07-01",{"name":5,"class":6},1]