[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616596":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":35,"responsibleParty":225,"collaborators":229,"id":235,"slug":236,"hasResults":237,"nctId":238,"briefTitle":239,"officialTitle":239,"acronym":240,"eligibilityCriteria":241,"healthyVolunteers":242,"sex":243,"minAge":20,"maxAge":20,"enrollmentInfo":244,"targetDuration":20,"studyType":247,"phases":248,"briefSummary":250,"conditions":251,"keywords":256,"overallStatus":38,"whyStopped":20,"lastUpdateSubmitDate":263,"lastUpdatePostDateStruct":264,"startDateStruct":267,"completionDateStruct":269,"leadSponsor":271,"locationsCount":272},{"fullName":5,"class":6},"Vanderbilt University Medical Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Oncology physicians and advanced practice providers","EXPERIMENTAL","Clinician members of oncology teams who care for adults with breast, pancreatic, or colorectal cancer will be the target population. We will assess changes in germline test orders for and completion by patients before and after deploying implementation strategies designed to promote testing uptake.",[13],"Behavioral: Implementation strategies",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"BEHAVIORAL","Implementation strategies","We will deploy different strategy bundles across the clinical sites in three approximate 6-month phases.\n\nPhase I - Facilitation of provider training, educational materials, and information resources; Patient-facing educational material and information resources Phase II - Audit and feedback report on existing patients; Practice champion support; Optimizing EHR strategies Phase III - EHR tools to facilitate prospective identification of patients, testing, and result reporting",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Josh F Peterson, MD, MPH","PRINCIPAL_INVESTIGATOR",[26,31],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Megan He, PhD","CONTACT","615-875-9641","megan.he@vumc.org",{"name":32,"role":28,"phone":33,"phoneExt":20,"email":34},"Lynn A Seabolt, MS, RD","615-875-7898","lynn.a.seabolt@vumc.org",[36,62,78,94,119,137,153,168,184,206],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"VA Greater Los Angeles Healthcare System","RECRUITING","Los Angeles","California","90073","United States","US",{"type":45,"coordinates":46},"Point",[47,48],-118.24368,34.05223,{"lat":48,"lon":47},[51,54,56,58,60],{"name":52,"role":28,"phone":20,"phoneExt":20,"email":53},"Abby Sokoloff","abby.sokoloff@va.gov",{"name":55,"role":24,"phone":20,"phoneExt":20,"email":20},"Jason Vassy, MD, MPH",{"name":57,"role":24,"phone":20,"phoneExt":20,"email":20},"Maren Scheuner, MD, MPH",{"name":59,"role":24,"phone":20,"phoneExt":20,"email":20},"Lori Orlando, MD",{"name":61,"role":24,"phone":20,"phoneExt":20,"email":20},"Deepak Voora, MD",{"facility":63,"status":38,"city":64,"state":65,"zip":66,"country":42,"countryCode":43,"cosmosGeoPoint":67,"geoPoint":71,"contacts":72},"Orlando VA Medical Center","Orlando","Florida","32827",{"type":45,"coordinates":68},[69,70],-81.37924,28.53834,{"lat":70,"lon":69},[73,74,75,76,77],{"name":52,"role":28,"phone":20,"phoneExt":20,"email":53},{"name":55,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":57,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":59,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":61,"role":24,"phone":20,"phoneExt":20,"email":20},{"facility":79,"status":38,"city":80,"state":81,"zip":82,"country":42,"countryCode":43,"cosmosGeoPoint":83,"geoPoint":87,"contacts":88},"Atlanta VA Medical Center","Decatur","Georgia","30033",{"type":45,"coordinates":84},[85,86],-84.29631,33.77483,{"lat":86,"lon":85},[89,90,91,92,93],{"name":52,"role":28,"phone":20,"phoneExt":20,"email":53},{"name":55,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":57,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":59,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":61,"role":24,"phone":20,"phoneExt":20,"email":20},{"facility":95,"status":38,"city":96,"state":97,"zip":98,"country":42,"countryCode":43,"cosmosGeoPoint":99,"geoPoint":103,"contacts":104},"Northwestern Medicine","Chicago","Illinois","60611",{"type":45,"coordinates":100},[101,102],-87.65005,41.85003,{"lat":102,"lon":101},[105,108,111,113,115,117],{"name":106,"role":28,"phone":20,"phoneExt":20,"email":107},"Martha Burla","martha.burla1@northwestern.edu",{"name":109,"role":28,"phone":20,"phoneExt":20,"email":110},"Daniel Blumenthal","daniel.blumenthal@northwestern.edu",{"name":112,"role":24,"phone":20,"phoneExt":20,"email":20},"Patricia D Franklin, MD, MPH, MBA",{"name":114,"role":24,"phone":20,"phoneExt":20,"email":20},"Rinad S Beidas, PhD",{"name":116,"role":24,"phone":20,"phoneExt":20,"email":20},"Elizabeth M McNally, MD, PhD",{"name":118,"role":24,"phone":20,"phoneExt":20,"email":20},"Lucy A Godley, MD, PhD",{"facility":120,"status":38,"city":121,"state":122,"zip":123,"country":42,"countryCode":43,"cosmosGeoPoint":124,"geoPoint":128,"contacts":129},"Indiana University School of Medicine","Indianapolis","Indiana","46202",{"type":45,"coordinates":125},[126,127],-86.15804,39.76838,{"lat":127,"lon":126},[130,133,135],{"name":131,"role":28,"phone":20,"phoneExt":20,"email":132},"Abi Colwell","abcolwel@iu.edu",{"name":134,"role":24,"phone":20,"phoneExt":20,"email":20},"Todd C Skaar, PhD",{"name":136,"role":24,"phone":20,"phoneExt":20,"email":20},"Paul R Dexter, MD",{"facility":138,"status":38,"city":139,"state":140,"zip":141,"country":42,"countryCode":43,"cosmosGeoPoint":142,"geoPoint":146,"contacts":147},"Durham VA Medical Center","Durham","North Carolina","27705",{"type":45,"coordinates":143},[144,145],-78.89862,35.99403,{"lat":145,"lon":144},[148,149,150,151,152],{"name":52,"role":28,"phone":20,"phoneExt":20,"email":53},{"name":55,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":57,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":59,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":61,"role":24,"phone":20,"phoneExt":20,"email":20},{"facility":154,"status":38,"city":155,"state":140,"zip":156,"country":42,"countryCode":43,"cosmosGeoPoint":157,"geoPoint":161,"contacts":162},"Salisbury VA Health Care System","Salisbury","28144",{"type":45,"coordinates":158},[159,160],-80.47423,35.67097,{"lat":160,"lon":159},[163,164,165,166,167],{"name":52,"role":28,"phone":20,"phoneExt":20,"email":53},{"name":55,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":57,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":59,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":61,"role":24,"phone":20,"phoneExt":20,"email":20},{"facility":169,"status":38,"city":170,"state":171,"zip":172,"country":42,"countryCode":43,"cosmosGeoPoint":173,"geoPoint":177,"contacts":178},"Geisinger","Danville","Pennsylvania","17822",{"type":45,"coordinates":174},[175,176],-76.61273,40.96342,{"lat":176,"lon":175},[179,182],{"name":180,"role":28,"phone":20,"phoneExt":20,"email":181},"Victoria Schlieder","schlieder@geisinger.edu",{"name":183,"role":24,"phone":20,"phoneExt":20,"email":20},"Adam H Buchanan, MS, MPH, CGC",{"facility":5,"status":38,"city":185,"state":186,"zip":187,"country":42,"countryCode":43,"cosmosGeoPoint":188,"geoPoint":192,"contacts":193},"Nashville","Tennessee","37203",{"type":45,"coordinates":189},[190,191],-86.78444,36.16589,{"lat":191,"lon":190},[194,197,200,202,204],{"name":195,"role":28,"phone":20,"phoneExt":20,"email":196},"Kelsey Rodriguez","kelsey.rodriguez@vumc.org",{"name":198,"role":28,"phone":20,"phoneExt":20,"email":199},"Kyle W Davis","kyle.w.davis@vumc.org",{"name":201,"role":24,"phone":20,"phoneExt":20,"email":20},"Dan Roden, MD",{"name":203,"role":24,"phone":20,"phoneExt":20,"email":20},"Alexander G Bick, MD, PhD",{"name":205,"role":24,"phone":20,"phoneExt":20,"email":20},"Sunil Kripalani, MD, MSc",{"facility":207,"status":38,"city":208,"state":209,"zip":210,"country":42,"countryCode":43,"cosmosGeoPoint":211,"geoPoint":215,"contacts":216},"University of Utah Health","Salt Lake City","Utah","84112",{"type":45,"coordinates":212},[213,214],-111.89105,40.76078,{"lat":214,"lon":213},[217,220,221,223],{"name":218,"role":28,"phone":20,"phoneExt":20,"email":219},"Kensaku Kawamoto, MD, PhD, MHS","kensaku.kawamoto@utah.edu",{"name":218,"role":24,"phone":20,"phoneExt":20,"email":20},{"name":222,"role":24,"phone":20,"phoneExt":20,"email":20},"Mark Yandell, PhD",{"name":224,"role":24,"phone":20,"phoneExt":20,"email":20},"Martin Tristani-Firouzi, MD",{"type":226,"investigatorFullName":227,"investigatorTitle":228,"investigatorAffiliation":5,"oldNameTitle":20,"oldOrganization":20},"SPONSOR_INVESTIGATOR","Josh Peterson","Professor of Biomedical Informatics and Medicine",[230,233],{"name":231,"class":232},"National Human Genome Research Institute (NHGRI)","NIH",{"name":234,"class":232},"National Cancer Institute (NCI)","100616596","increasing-germline-genetic-testing-for-patients-with-cancer-100616596",false,"NCT07307664","Increasing Germline Genetic Testing for Patients With Cancer","gLHS","Inclusion Criteria:\n\n* Oncology care team members (including, but not limited to, oncologists, advanced practice providers, nurse navigators, caring for patients with adult patients with breast cancer, pancreatic cancer or colorectal cancer.\n\nExclusion Criteria:\n\n* Providers not on the oncology care team",true,"ALL",{"count":245,"type":246},1000,"ESTIMATED","INTERVENTIONAL",[249],"NA","Germline testing for hereditary cancer syndromes is underutilized across most health care settings. Using a learning health care approach, the Genomics-enabled Learning Health Systems (gLHS) network aims to evaluate the impact of a suite of implementation strategies to increase germline test ordering by oncology care teams (i.e., mainstreaming) for eligible patients with breast, pancreatic or colorectal cancer. Secondarily, the study will investigate completion of testing by eligible patients, as well as impact on overall rates of germline test ordering in patients with cancer. The network will bundle and deploy different implementation strategies across the clinical sites in three 6-month phases. A maintenance phase after the implementation periods will measure genetic testing rates without any additional implementation strategies to determine persistence of effects. The implementation strategies address clinician-level factors, and thus oncologists and their team members (e.g. advanced practice providers, nurse navigators, case managers) will be the focus of evaluating the impact of implementation strategies. Strategies that will be considered include provider education, audit and feedback reports, facilitation, peer support, and electronic health record (EHR) system optimization to support germline testing. Using the RE-AIM QuEST framework, outcomes will be assessed using mixed methods separately for each eligible cancer type. Data collection from the EHR, other relevant data sources, and qualitative provider feedback will be used to assess ordering and completion of tests and the effect of the implementation strategies on germline testing rates in oncology clinics.",[252,253,254,255],"Hereditary Pancreatic Cancer","Conditions or Focus of Study","Hereditary Breast Cancer","Hereditary Colorectal Cancer",[257,258,259,260,261,262],"Genomic Risk","Germline Testing","Hereditary Cancer","Learning Health Systems","Genomic Cancer Risk Assessment","Mainstreaming","2026-06-04",{"date":265,"type":266},"2026-06-09","ACTUAL",{"date":268,"type":266},"2026-01-30",{"date":270,"type":246},"2030-01-01",{"name":227,"class":6},10]