[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100556302":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":28,"centralContacts":32,"locations":41,"responsibleParty":61,"collaborators":64,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":24,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":104},{"fullName":5,"class":6},"University of Houston","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Neuromuscular coordination-guided rehabilitative training","EXPERIMENTAL","Post-stroke participants will perform a center-out task by generating isometric contractions of multiple muscles to move the cursor on a screen while electromyographic (EMG) responses are recorded. Activation of each muscle (or muscle group) will be mapped to 1 of 4 directions within the multi-dimensional cursor space. We will derive the cursor position in real time using EMGs recorded from multiple arm muscles.",[13],"Other: Neuromuscular coordination-guided rehabilitative training",{"label":15,"type":16,"description":17,"interventionNames":18},"Force strengthening-guided rehabilitative training","ACTIVE_COMPARATOR","Post-stroke participants will perform a center-out task by generating isometric force to move the cursor on a screen. Participants will generate isometric force, which will move their cursor on the monitor. They will be trained to match one of the four force targets on display. We will derive the cursor position in real time using three forces (Fx, Fy, and Fz) measured at the load cell.",[19],"Other: Force strengthening-guided rehabilitative training",[21,25],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"During training exercise, post-stroke participants will be asked to match the targets on the screen. The experimental group will match them by activating a specific set of muscle. During assessment trials, a physical therapist or occupational therapist will rate the functional level of arm impairment using FMA and ARAT.",[9],null,{"type":6,"name":15,"description":26,"armGroupLabels":27,"otherNames":24},"During training exercise, post-stroke participants will be asked to match the targets on the screen. The active comparator group will match them by generating isometric force in a desired target direction. During assessment trials, a physical therapist or occupational therapist will rate the functional level of arm impairment using FMA and ARAT.",[15],[29],{"name":30,"affiliation":5,"role":31},"Jinsook Roh, PhD","PRINCIPAL_INVESTIGATOR",[33,37],{"name":30,"role":34,"phone":35,"phoneExt":24,"email":36},"CONTACT","7137432578","jroh@Central.UH.EDU",{"name":38,"role":34,"phone":39,"phoneExt":24,"email":40},"Manuel A Portilla-Jiménez, MS, BME","3467194921","maportillajimenez@uh.edu",[42],{"facility":5,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Houston","Texas","77204","United States","US",{"type":50,"coordinates":51},"Point",[52,53],-95.36327,29.76328,{"lat":53,"lon":52},[56,59],{"name":30,"role":34,"phone":57,"phoneExt":24,"email":58},"713-743-2578","jroh@central.uh.edu",{"name":38,"role":34,"phone":60,"phoneExt":24,"email":40},"346-719-4921",{"type":31,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Jinsook Roh","Assistant Professor",[65,67],{"name":66,"class":6},"Korea Advanced Institute of Science and Technology",{"name":68,"class":6},"The University of Texas Health Science Center, Houston","100556302","increasing-the-repertoire-of-intermuscular-co-ordination-post-stroke-through-emg-guided-human-machine-interaction-100556302",false,"NCT06523335","Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction","Intermuscular Coordination as a Novel Clinical Target for Stroke Neurorehabilitation","NICE","Inclusion criteria for aged matched healthy group\n\n* Male or female whose age range between 40 and 75\n* no known neurological injuries\n\nExclusion criteria for aged matched healthy group\n\n* have an orthopedic disorder involving upper limbs;\n* have a history of any neurologic disease;\n* have any history of epilepsy of the potential participants and\u002For their family members;\n* are unable to consent;\n* are pregnant.\n\nInclusion criteria for stroke group\n\n* male or female hemiparetic chronic stroke survivors;\n* age ranging between 40-75 year;\n* with single unilateral ischemic or hemorrhagic middle cerebral artery stroke;\n* neurologically stable for \\>6 months;\n* have an expectation that current medication will be maintained without changes for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted;\n* without severe spasticity (Modified Ashworth (MA) \\\u003C4);\n* have not received botulinum toxin on the impaired arm within 3 months.\n\nExclusion criteria for stroke group\n\n* have an orthopedic disorder involving upper limbs;\n* cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol (Montreal Cognitive Assessment (MoCA) score \\\u003C 26);\n* a history of another neurologic disease;\n* anesthesia of joint position sense in upper limbs;\n* are pregnant or have a chance that they might be (self-reported);",true,"ALL","40 Years","75 Years",{"count":82,"type":83},74,"ESTIMATED","INTERVENTIONAL",[86],"NA","The purposes of this study include:\n\n1. \\- To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke.\n2. \\- To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.",[89],"Stroke",[91,92,93,94,89],"Muscle synergy","Intermuscular Coordination","Electromyogram-guided exercise","Motor neurorehabilitation","2026-04-28",{"date":97,"type":98},"2026-05-04","ACTUAL",{"date":100,"type":98},"2024-10-01",{"date":102,"type":83},"2029-09-01",{"name":5,"class":6},1]