[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100525256":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":29,"centralContacts":33,"locations":25,"responsibleParty":39,"collaborators":25,"id":42,"slug":43,"hasResults":44,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":25,"eligibilityCriteria":48,"healthyVolunteers":44,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":25,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":25,"overallStatus":64,"whyStopped":25,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":25},{"fullName":5,"class":6},"RenJi Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Single daily icodextrin exchange group","EXPERIMENTAL","For incident peritoneal dialysis (PD) patients assigned to the experimental arm, PD is initiated with single daily exchange of 2-liter icodextrin-based dialysis solution. The daily dwell time ranges from 8-24 hours per day, depending on the patient's clinical conditions. Additional exchange(s) of glucose-based dialysis solution will be added to increase uremic toxins and fluid removal if necessary during the follow-up.",[13],"Other: Single daily icodextrin exchange",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional PD group","ACTIVE_COMPARATOR","For incident peritoneal dialysis (PD) patients assigned to this arm, PD is initiated with 2 to 3 exchanges of 2-liter glucose-based solution. The daily dwell time ranges from 8-24 hours per day, depending on the patient's clinical conditions. Additional exchange(s) of glucose-based dialysis solution will be added to increase uremic toxins and fluid removal if necessary during the follow-up.",[19],"Other: Conventional PD group",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Single daily icodextrin exchange","PD initiation with single daily exchange of 2-liter icodextrin-based dialysis solution.",[9],null,{"type":6,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"PD is initiated with 2 to 3 exchanges of 2-liter glucose-based dialysis solution.",[15],[30],{"name":31,"affiliation":5,"role":32},"Wei Fang, MD., PhD.","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":25,"email":38},"Hao Yan, MD.","CONTACT","0086-13816588689","dryanhao@163.com",{"type":32,"investigatorFullName":40,"investigatorTitle":41,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Wei Fang","Clinical Professor","100525256","incremental-pd-with-single-icodextrin-exchange-100525256",false,"NCT06119373","Incremental PD With Single Icodextrin Exchange","Initiation of Incremental Dialysis With Single Daily Icodextrin Exchange: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. male or female patients aged 18 to 75 years;\n2. patients with chronic kidney disease stage 5 who are to start PD;\n3. eGFR ≥ 5 ml\u002Fmin;\n4. urine output ≥ 800 ml\u002Fd.\n\nExclusion Criteria:\n\n1. documented anaphylaxis with icodextrin or glucose-based dialysate;\n2. concomitant severe chronic diseases such as malignancy, hepatitis, severe cardiac diseases, etc.;\n3. ongoing severe infection;\n4. planned or ongoing pregnancy or lactation;\n5. currently enrolled in other clinical studies;\n6. patients who have a life expectancy of \\\u003C12 months;\n7. refusal to give a written consent.","ALL","18 Years","75 Years",{"count":53,"type":54},72,"ESTIMATED","INTERVENTIONAL",[57],"NA","Objectives: To investigate the efficacy and safety of single daily icodextrin exchange for initiation of incremental peritoneal dialysis (PD).\n\nSubjects: Seventy-two incident PD patients.\n\nMethods: A single-center randomized controlled trial.\n\nPrimary outcome: Change in residual kidney function in 48 weeks after recruitment.",[60,61,62,63],"Peritoneal Dialysis Complication","Residual Kidney Function","Survival","Health-related Quality of Life","NOT_YET_RECRUITING","2023-11-05",{"date":67,"type":68},"2023-11-08","ACTUAL",{"date":70,"type":54},"2023-12-01",{"date":72,"type":54},"2026-11-30",{"name":5,"class":6}]