[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622761":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":52,"collaborators":11,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":11,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":11,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":81,"whyStopped":11,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Aerospace Center Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Lung-Protective Ventilation Group","ACTIVE_COMPARATOR",null,[13],"Procedure: Standard Lung-Protective Ventilation",{"label":15,"type":16,"description":11,"interventionNames":17},"Individualized Open Lung Ventilation Group","EXPERIMENTAL",[18],"Procedure: Individualized Open Lung Ventilation",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":11},"PROCEDURE","Standard Lung-Protective Ventilation","Standard lung-protective ventilation is applied during one-lung ventilation. Ventilation parameters include a tidal volume of 6 mL\u002Fkg predicted body weight and a fixed positive end-expiratory pressure (PEEP) of 5 cmH2O throughout one-lung ventilation. No routine recruitment maneuver is performed during one-lung ventilation. At the end of one-lung ventilation, a standardized lung recruitment maneuver is applied before resuming two-lung ventilation.",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":11},"Individualized Open Lung Ventilation","Individualized open lung ventilation is applied during one-lung ventilation. Tidal volume is set at 4-6 mL\u002Fkg predicted body weight. After lung recruitment, a decremental PEEP trial is performed starting from 10 cmH2O, with PEEP reduced stepwise to identify the level associated with the lowest driving pressure. The selected PEEP is maintained throughout one-lung ventilation. A standardized lung recruitment maneuver is applied at the end of one-lung ventilation before resuming two-lung ventilation.",[15],[30],{"name":31,"affiliation":5,"role":32},"Xiangli Zheng","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},"Xinrui Yin","CONTACT","+86-13029315156","ahywvn@pku.org.cn",[40],{"facility":5,"status":11,"city":41,"state":11,"zip":11,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Beijing","China","CN",{"type":45,"coordinates":46},"Point",[47,48],116.39723,39.9075,{"lat":48,"lon":47},[51],{"name":35,"role":36,"phone":37,"phoneExt":11,"email":38},{"type":32,"investigatorFullName":35,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"Doctor","100622761","individualized-open-lung-ventilation-and-postoperative-pulmonary-complications-in-thoracic-surgery-100622761",false,"NCT07387822","Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery","Effect of Individualized Versus Standardized Open-Lung Ventilation on Postoperative Pulmonary Complications in Thoracic Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 18 to 75 years.\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Body mass index between 18 and 30 kg\u002Fm².\n* Scheduled for elective video-assisted thoracoscopic surgery (VATS).\n* Expected duration of one-lung ventilation longer than 1 hour.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* Emergency surgery or reoperation.\n* History of severe pulmonary disease, including chronic obstructive pulmonary disease, pulmonary fibrosis, severe emphysema, pulmonary bullae, pneumothorax, or uncontrolled asthma.\n* History of heart failure or coronary artery disease.\n* Previous thoracic surgery or mechanical ventilation within 1 month before surgery.\n* Planned postoperative mechanical ventilation.\n* Bilateral thoracic surgery.\n* Participation in another interventional clinical trial.\n* Conversion to open thoracotomy during surgery.","ALL","18 Years","75 Years",{"count":65,"type":66},352,"ESTIMATED","INTERVENTIONAL",[69],"NA","This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative \"Individualized Open Lung Ventilation\" strategy compared to a standard lung-protective ventilation strategy in patients undergoing thoracic surgery.\n\nOne-lung ventilation (OLV) is essential for thoracic surgery but can cause lung injury. While standard care often uses fixed ventilation parameters, this study investigates whether personalizing Positive End-Expiratory Pressure (PEEP) to achieve the lowest driving pressure can reduce the incidence of postoperative pulmonary complications (PPCs) within 7 days after surgery.",[72,73,74],"Postoperative Pulmonary Complications (PPCs)","One-lung Ventilation (OLV)","Thoracic Surgery, Video Assisted",[26,76,77,78,79,80],"Driving Pressure","PEEP Titration","Lung Recruitment Maneuver","Lung Protective Ventilation","Video-Assisted Thoracic Surgery","NOT_YET_RECRUITING","2026-01-30",{"date":84,"type":85},"2026-02-04","ACTUAL",{"date":87,"type":66},"2026-02-10",{"date":89,"type":66},"2026-05-10",{"name":5,"class":6},1]