[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637429":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":43,"responsibleParty":57,"collaborators":25,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":25,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":25,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":86,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Bursa City Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Mechanical Power Group","EXPERIMENTAL","Driving pressure-guided individualized PEEP group",[13],"Other: Driving pressure-based personalized PEEP strategy",{"label":15,"type":16,"description":17,"interventionNames":18},"Lung Protective Ventilation","OTHER","Conventional lung-protective ventilation group",[19],"Other: Conventional lung protective mechanical ventilation strategy",[21,26],{"type":16,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Driving pressure-based personalized PEEP strategy","After hemodynamic stability is achieved, the ventilator will be switched to volume-controlled mode with 6 ml\u002Fkg tidal volume , and a recruitment maneuver will be performed by gradually increasing PEEP to 20 cmH₂O. Subsequently, during the decremental PEEP trial, PEEP will be reduced by 2 cmH₂O every 20 seconds down to 6 cmH₂O, and ΔP (Pplat-PEEP) will be calculated at each step.\n\nThe PEEP level associated with the lowest ΔP on the ΔP-PEEP curve will be identified, a second recruitment maneuver will be performed, and PEEP will then be fixed at this level. Before sternotomy, the minimum PEEP value that provides the lowest driving pressure will be determined, and this value will be maintained throughout the perioperative period, except during cardiopulmonary bypass.",[9],null,{"type":16,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Conventional lung protective mechanical ventilation strategy","In volume-controlled mechanical ventilation, tidal volume will be set at 6 mL\u002Fkg and PEEP will be fixed at 5 cmH₂O. Ventilation will be maintained with these settings throughout the perioperative period, except during cardiopulmonary bypass. Mechanical power values will also be calculated and recorded during all these periods.",[15],[31],{"name":32,"affiliation":33,"role":34},"eralp cevikkalp","Burs City Hospital","STUDY_CHAIR",[36,40],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},"CONTACT","905054554875","eralpcevikkalp@hotmail.com",{"name":41,"role":37,"phone":25,"phoneExt":25,"email":42},"İrem Aydoğmuş","driremaydogmus@hotmail.com",[44],{"facility":5,"status":25,"city":45,"state":46,"zip":47,"country":48,"countryCode":25,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Bursa","nilüfer","16000","Turkey (Türkiye)",{"type":50,"coordinates":51},"Point",[52,53],29.06013,40.19559,{"lat":53,"lon":52},[56],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"type":58,"investigatorFullName":59,"investigatorTitle":60,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","eralp çevikkalp","Association Professor","100637429","individualized-peep-and-pulmonary-complications-in-on-pump-cabg-100637429",false,"NCT07623109","Individualized PEEP and Pulmonary Complications in On-Pump CABG","Effect of Individualized PEEP Guided by Driving Pressure and Mechanical Power on Postoperative Pulmonary Complications in On-Pump CABG: A Randomized Controlled Trial","Patients with ASA physical status II-III who are scheduled to undergo elective open-heart surgery via on-pump median sternotomy will be included in the study.\n\nPatients scheduled for emergency surgery, those planned to undergo off-pump cardiac surgery, patients with a history of myocardial infarction within the last 3 months, patients with advanced COPD, patients with an ARISCAT score of 44 or higher, patients with a BMI of 35 kg\u002Fm² or higher, patients with NYHA class IV status, patients receiving preoperative immunotherapy, and patients with severe hepatic or renal failure will be excluded from the study.","ALL","18 Years","80 Years",{"count":72,"type":73},80,"ESTIMATED","INTERVENTIONAL",[76],"NA","Postoperative pulmonary complications (PPCs) are an important cause of morbidity and mortality after major surgery and are frequently observed in cardiac surgery patients undergoing cardiopulmonary bypass (CPB). These complications are associated with prolonged mechanical ventilation, longer intensive care unit and hospital stays, increased healthcare costs, and higher mortality (1,2).\n\nIntraoperative lung-protective ventilation strategies have traditionally focused on individual parameters such as low tidal volume, positive end-expiratory pressure (PEEP), plateau pressure, and driving pressure. However, the effects of these parameters on postoperative pulmonary outcomes in cardiac surgery patients remain unclear. In particular, PEEP- and driving pressure-guided approaches are controversial in terms of feasibility and safety in patients undergoing CPB, who may be hemodynamically vulnerable.\n\nMechanical power is a comprehensive parameter that reflects the total energy delivered to the respiratory system per unit of time by integrating ventilatory variables such as tidal volume, airway pressures, respiratory rate, and flow. Therefore, mechanical power may provide a more comprehensive assessment of the mechanical load applied to the lungs compared with individual ventilatory parameters. Previous studies have reported that higher mechanical power values may be associated with lung injury, postoperative pulmonary complications, and mortality (3).\n\nThe aim of this study is to evaluate the effect of monitoring mechanical power during perioperative mechanical ventilation on postoperative pulmonary complications in patients undergoing cardiac surgery with cardiopulmonary bypass. The study hypothesis is that a mechanical power-based ventilation approach may reduce the incidence of PPCs compared with strategies based on conventional ventilation parameters.",[79,80,81],"Cardiac Surgery","Mechanical Power","Postoperative Pulmonary Complications (PPCs)",[83,84,85],"cardica surgery","mechanical power","postoperative pulmonary complications","NOT_YET_RECRUITING","2026-06-01",{"date":89,"type":90},"2026-06-03","ACTUAL",{"date":92,"type":73},"2026-05-15",{"date":94,"type":73},"2026-07-15",{"name":5,"class":6},1]