[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601055":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":39,"responsibleParty":59,"collaborators":62,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":24,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":42,"whyStopped":24,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Glostrup University Hospital, Copenhagen","OTHER",[8,13],{"label":9,"type":10,"description":9,"interventionNames":11},"Placebo","PLACEBO_COMPARATOR",[12],"Dietary Supplement: Placebo",{"label":14,"type":15,"description":16,"interventionNames":17},"Indole-3-propionic acid (IPA)","EXPERIMENTAL","IPA: total daily dose of 1000 mg",[18],"Dietary Supplement: Indole-3-propionic acid (IPA)",[20,25],{"type":21,"name":14,"description":22,"armGroupLabels":23,"otherNames":24},"DIETARY_SUPPLEMENT","Two capsules are taken every morning and two capsules are taken every evening for 14 consecutive days. Active capsules are taken orally and contain 250 mg of IPA each.",[14],null,{"type":21,"name":9,"description":26,"armGroupLabels":27,"otherNames":24},"Two capsules are taken every morning and two capsules are taken every evening for 14 consecutive days. Placebo capsules are taken orally and contain maltodextrin.",[9],[29],{"name":30,"affiliation":31,"role":32},"Jette Frederiksen, Prof, MD","Copenhagen University Hospital, Rigshospitalet-Glostrup","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":24,"email":38},"Moschoula Passali, MSc, PhD","CONTACT","+45 38633467","moschoula.passali@regionh.dk",[40],{"facility":41,"status":42,"city":43,"state":24,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"Optic Neuritis Clinic, Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet-Glostrup","RECRUITING","Glostrup Municipality","2600","Denmark","DK",{"type":48,"coordinates":49},"Point",[50,51],12.40377,55.6666,{"lat":51,"lon":50},[54,58],{"name":55,"role":36,"phone":56,"phoneExt":24,"email":57},"Jette Lautrup Frederiksen, Prof, MD","+4538633041","jette.lautrup.battistini@regionh.dk",{"name":55,"role":32,"phone":24,"phoneExt":24,"email":24},{"type":32,"investigatorFullName":60,"investigatorTitle":61,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Jette Lautrup Frederiksen","Prof, DMSc, MD",[63,65],{"name":64,"class":6},"University of Copenhagen",{"name":66,"class":6},"University of Southampton","100601055","indole-3-propionic-acid-clinical-trials---a-pilot-study-part-2-100601055",false,"NCT07105514","Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2","Indole-3-PROpionic Acid Clinical Trials - a Pilot Study Part 2 (iPROACT-pilot2)","iPROACT-pilot2","Inclusion Criteria:\n\n* Healthy women and men ≥18 and ≤65 years of age\n* Deemed mentally and physically able to participate\n\nExclusion Criteria:\n\n* Diagnosis of gut-, heart-, liver-, kidney or immune-related disorders\n* Use of antibiotics within the last month\n* Pregnancy, lactation or childbirth within the last five months\n* Use of prescription medication",true,"ALL","18 Years","65 Years",{"count":80,"type":81},32,"ESTIMATED","INTERVENTIONAL",[84],"NA","The goal of this trial is to investigate the biological effects of oral supplementation with indole-3-propionic acid (IPA) taken twice daily in healthy adults. The main scientific questions are:\n\n* Does supplementation with IPA increase the abundance of regulatory T cells in the blood? Regulatory T cells are believed to play an important role in preventing autoimmune diseases.\n* Does supplementation with IPA increase the concentration of brain-derived neurotrophic factor (BDNF) in the blood? BDNF is believed to play an important role in maintaining brain health.\n* Does supplementation with IPA affect blood analyses commonly performed to assess the risk of metabolic disorders like type 2 diabetes and cardiovascular diseases?\n\nParticipants will:\n\n* Take capsules to achieve a total daily dose of 1000 mg of IPA or placebo: 500 mg every morning and 500 mg every evening for 14 days.\n* Visit the clinic at the beginning (day 1) and at the end (day 15) of the supplementation period to deliver blood, urine and fecal samples, have simple measurements performed, fulfil questionnaires and report any side effects.",[87],"Healthy",[89,90,91,92,93],"indole-3-propionic acid","gut bacterial metabolite","regulatory T cells","brain-derived neurotrophic factor","dietary supplement","2025-08-07",{"date":96,"type":97},"2025-08-08","ACTUAL",{"date":99,"type":97},"2025-08-04",{"date":101,"type":81},"2026-06-30",{"name":5,"class":6},1]