[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615384":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":18,"centralContacts":31,"locations":40,"responsibleParty":52,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":74,"overallStatus":43,"whyStopped":10,"lastUpdateSubmitDate":79,"lastUpdatePostDateStruct":80,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":88},{"fullName":5,"class":6},"Akdeniz University","OTHER",[8,12,15],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients with ARDS and Were Followed in ICU After Trauma",null,"Patients who developed ARDS and were followed in intensive care for at least 3 days after trauma",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients without ARDS and Were Followed in ICU After Trauma","Patients who does not developed ARDS and were followed in intensive care for at least 3 days after trauma",{"label":16,"type":10,"description":17,"interventionNames":10},"Control Group","Control group of healthy volunteers of similar age and gender",[19,23,26,29],{"name":20,"affiliation":21,"role":22},"Melike Cengiz, Prof Dr","Department of Anesthesiology and Reanimation, Akdeniz University Hospital","STUDY_DIRECTOR",{"name":24,"affiliation":21,"role":25},"Canberk Kurban, Resident Physician","PRINCIPAL_INVESTIGATOR",{"name":27,"affiliation":28,"role":25},"Şükran Burçak Yoldaş, Prof Dr","Department of Medical Biology, Akdeniz University Hospital",{"name":30,"affiliation":21,"role":25},"Ülkü Arslan, Specialist Physician",[32,36],{"name":20,"role":33,"phone":34,"phoneExt":10,"email":35},"CONTACT","+905424317975","melikecengiz@yahoo.com",{"name":37,"role":33,"phone":38,"phoneExt":10,"email":39},"Canberk Kurban","+905393626841","canberkkrbn@gmail.comd",[41],{"facility":42,"status":43,"city":44,"state":45,"zip":46,"country":47,"countryCode":10,"cosmosGeoPoint":10,"geoPoint":10,"contacts":48},"Akdeniz University Hospital","RECRUITING","Antalya","Ağrı","04200","Turkey (Türkiye)",[49],{"name":50,"role":33,"phone":38,"phoneExt":10,"email":51},"Canberk Kurban, Resident Physycian","canberkkrbn@gmail.com",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"SPONSOR_INVESTIGATOR","Melike Cengiz","Prof Dr","100615384","inflammation-severity-and-mirna-126-in-trauma-100615384",false,"NCT07291908","Inflammation Severity and miRNA-126 in Trauma","Correlation of Inflammation Severity With Pulmonary Gas Exchange and MiRNA 126 in Trauma Patients","Inclusion Criteria:\n\nAdults aged 18 years or older.\n\nPatients monitored and treated for trauma in the anesthesia intensive care units of Akdeniz University Faculty of Medicine.\n\nExclusion Criteria:\n\nPatients younger than 18 years.\n\nPatients with concomitant thoracic trauma.\n\nPresence of active infection prior to trauma.\n\nPatients not admitted to the ICU within the first 24 hours after trauma.\n\nPatients who remain in the ICU for less than 72 hours following trauma.\n\nCurrent use of steroids, chemotherapy, or antibiotic therapy prior to ICU admission.\n\nPatients with immunodeficiency.\n\nPatients who are in shock prior to or during ICU admission.",true,"ALL","18 Years",{"count":67,"type":68},130,"ESTIMATED","OBSERVATIONAL","Trauma triggers a complex immune response intended to eliminate danger signals and restore physiological balance. Early post-traumatic inflammation is primarily initiated by damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs). In patients with severe trauma, dysregulated inflammation increases susceptibility to infection, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), and mortality. The lungs are particularly vulnerable, and excessive inflammatory activation may lead to acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), conditions characterized by increased vascular permeability, alveolar epithelial injury, surfactant dysfunction, and impaired gas exchange.\n\nPro-inflammatory cytokines, activated neutrophils, reactive oxygen species, and proteases contribute to endothelial and epithelial barrier disruption. Recent evidence also suggests that several microRNAs, including miR-126, may play a regulatory role in pulmonary barrier integrity through modulation of tight-junction proteins and PI3K\u002FAKT-related pathways.\n\nAlthough many components of the trauma-related inflammatory response have been described, the relationship between systemic inflammatory severity and impairment of pulmonary gas exchange remains insufficiently defined in clinical settings.\n\nThis study aims to investigate the correlation between inflammatory severity markers (C-reactive protein, procalcitonin, IL-6, reactive oxygen derivatives, neutrophil-to-lymphocyte ratio, lactate), imaging findings (flow-mediated dilation by ultrasound), clinical parameters (blood pressure, heart rate, urine output, vasoactive medication requirements), pulmonary gas-exchange measurements (arterial blood gases, PaO₂\u002FFiO₂ ratio), and circulating miRNA-126 levels in trauma patients. The findings may help identify biomarkers that better reflect inflammatory burden and the risk of lung dysfunction following trauma.",[72,73],"Trauma ICU Patients","Endothelial Injury",[75,76,77,78],"ARDS","MULTITRAUMA","MICRORNAS","ENDOTHEL","2025-12-05",{"date":81,"type":82},"2025-12-18","ACTUAL",{"date":84,"type":82},"2025-06-17",{"date":86,"type":68},"2027-01-10",{"name":54,"class":6},1]