[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641739":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":31,"locations":25,"responsibleParty":37,"collaborators":25,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":25,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":25,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":25,"overallStatus":61,"whyStopped":25,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":25},{"fullName":5,"class":6},"Escoles Universitaries Gimbernat","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vagus nerve electrical stimulation group","EXPERIMENTAL","The intervention consists of applying electrical transcutaneous stimulation to the auricular branch of the vagus nerve with a 2-pole stimulation electrode. A commercial transcutaneous electrical stimulation device approved for use in humans (tVNS R (Hook), from tVNS® Technologies GmbH, Erlangen (Germany)) will be used. Electrode will be placed on the left ear in contact with the cymba conchae, an area innervated by the auricular branch of the left vagus nerve.\n\nStimulation protocol: Stimulation will be administered in cycles of 60 minutes\u002Fday for 10 days (5 days a week). The stimulation parameters are: Pulse width: 500 μs, Frequency: 25 Hz, Alternating duty cycle: 60 seconds ON followed by 10 seconds OFF, Total time: 60 minutes per day. Current intensity: 200% of the perception threshold, provided it is tolerated and does not cause pain.",[13],"Device: Electrical stimulation of the vagus nerve",{"label":15,"type":10,"description":16,"interventionNames":17},"Vagus nerve manual stimulation group","The intervention consists of applying a protocol of manual therapy techniques to the vagus nerve and along its path, during 4 sessions of 30 minutes each, 2 interventions per week for 2 consecutive weeks.\n\nThe therapeutic protocol is structured around a total of nine specific manoeuvres. The intervention will begin with the application of three techniques targeting the cervical region, followed by two manoeuvres focusing on the anterior region of the neck. This will be followed by two techniques performed on the thorax and, finally, two mobilisations targeting the abdominal region.\n\nThe protocol will be based on previously published studies: Bayo-Tallón V and Giles PD.",[18],"Procedure: Manual stimulation of vagus nerve",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Electrical stimulation of the vagus nerve","The intervention consists of applying transcutaneous electrical stimulation to the auricular branch of the vagus nerve using a bipolar stimulation electrode. A commercially available transcutaneous electrical stimulation device approved for human use will be used (tVNS R (Hook), from tVNS® Technologies GmbH, Erlangen, Germany). The electrode will be placed on the left ear in contact with the cimba turbinate, an area innervated by the auricular branch of the left vagus nerve. Stimulation protocol: Stimulation will be administered in 60-minute\u002Fday cycles for 10 days (5 days a week). Stimulation parameters are: Pulse width: 500 μs, Frequency: 25 Hz, Alternating duty cycle: 60 seconds ON followed by 10 seconds OFF, Total time: 60 minutes per day. Current intensity: 200% of the perception threshold, as long as it is tolerated and does not cause pain.",[9],null,{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":25},"PROCEDURE","Manual stimulation of vagus nerve","The intervention consists of applying a protocol of manual therapy techniques to the vagus nerve and its pathway, during four 30-minute sessions, two interventions per week for two consecutive weeks. The therapeutic protocol is structured around a total of nine specific maneuvers. The intervention will begin with the application of three techniques targeting the cervical region, followed by two maneuvers focused on the anterior region of the neck. Two techniques will then be performed on the thorax, and finally, two mobilizations targeting the abdominal region.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":25,"email":36},"Jorge Esquirol Caussa","CONTACT","610083409","jordi.esquirol@eug.es",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Lluïsa Porte","Associate Professor of Physiotherapy and PhD student","100641739","influence-of-manual-and-electrical-vagal-stimulation-on-autonomic-activity-and-other-dysautonomous-symptoms-in-a-healthy-population-100641739",false,"NCT07660744","Influence of Manual and Electrical Vagal Stimulation on Autonomic Activity and Other Dysautonomous Symptoms in a Healthy Population.","Influence of Manual and Electrical Vagal Stimulation on Autonomic Activity (Heart Rate Variability) and Other Dysautonomous Symptoms Such as Fatigue and Sleep Disturbances, in a Healthy Population.","Inclusion Criteria:\n\n* Healthy volunteers between 40 and 70 years of age.\n* No known neurological pathology.\n* Willingness to participate voluntarily in the study.\n\nExclusion criteria:\n\n* Cognitive impairment objectively assessed by a neurologist and considered relevant.\n* Contraindications for the application of transcutaneous auricular stimulation (implanted cardiac pacemaker or deep brain stimulation treatment).\n* Consumption of tea, caffeine, energy drinks, alcohol or tobacco in the two hours prior to the intervention.",true,"ALL","40 Years","70 Years",{"count":53,"type":54},16,"ESTIMATED","INTERVENTIONAL",[57],"NA","The objective of this clinical, longitudinal, prospective, randomised (randomised) unmasked study is to analyse whether electrical and manual vagal stimulation produces changes in heart rate variability in a healthy population and it have a beneficial clinical effect in reducing dysautonomic symptoms.\n\nThe main questions it seeks to answer are:\n\n* Will non-invasive (manual and electrical) stimulation of the vagus nerve produce a significant change in heart rate variability, generating effects on the regulation of the autonomic nervous system, increasing the activation of the parasympathetic nervous system and decreasing the activation of the sympathetic nervous system?\n* Will non-invasive (manual and electrical) stimulation of the vagus nerve have a beneficial clinical effect in reducing dysautonomic symptoms such as fatigue and improving sleep quality?\n* Will noninvasive (manual and electrical) vagus nerve stimulation improve quality of life?\n* Are there differences in the level of satisfaction with the treatment after the intervention program received?\n\nTwo groups of participants will be formed:\n\n* Transcutaneous auricular vagus nerve stimulation consists of applying electrical stimulation to the auricular branch of the vagus nerve using a 2-pole stimulation electrode. Stimulation is performed for 1 hour per day for 10 days (5 days per week).\n* Manual vagus nerve intervention consists of applying a protocol of manual therapy techniques to the vagus nerve and along its path, during 4 sessions lasting 30 minutes, 2 interventions per week.",[60],"Healthy","NOT_YET_RECRUITING","2026-06-16",{"date":64,"type":65},"2026-06-22","ACTUAL",{"date":67,"type":54},"2026-07",{"date":69,"type":54},"2026-10",{"name":5,"class":6}]