[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626682":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":31,"centralContacts":45,"locations":55,"responsibleParty":75,"collaborators":31,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":84,"sex":85,"minAge":86,"maxAge":87,"enrollmentInfo":88,"targetDuration":31,"studyType":91,"phases":92,"briefSummary":94,"conditions":95,"keywords":97,"overallStatus":58,"whyStopped":31,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Universite du Littoral Cote d'Opale","OTHER",[8,16,21],{"label":9,"type":10,"description":11,"interventionNames":12},"Physical Activity + tDCS","EXPERIMENTAL","Participants undergo baseline assessments of corticospinal excitability and intracortical and sensorimotor circuits using transcranial magnetic stimulation (TMS).\n\nThey then perform 20 minutes of moderate-intensity aerobic exercise on a cycle ergometer at 50% of heart rate reserve, maintaining a cadence of 60 to 70 revolutions per minute (rpm).\n\nImmediately after exercise, participants receive 20 minutes of anodal transcranial direct current stimulation (tDCS) applied over the primary motor cortex (M1).\n\nPost-intervention TMS assessments are conducted using the same single- and paired-pulse paradigms to evaluate changes in corticospinal excitability and intracortical and sensorimotor circuits following the combined aerobic exercise and anodal tDCS intervention.",[13,14,15],"Behavioral: Aerobic Exercise","Device: Transcranial Magnetic Stimulation","Device: transcranial direct current stimulation",{"label":17,"type":10,"description":18,"interventionNames":19},"Physical Inactivity + tDCS","Participants undergo baseline assessments of corticospinal excitability and intracortical and sensorimotor circuits using transcranial magnetic stimulation (TMS). They then remain seated for 20 minutes and watch a silent video of natural waterfall scenes without narration. This condition is designed to provide a standardized and controlled resting period comparable across participants.\n\nImmediately after, participants receive 20 minutes of anodal transcranial direct current stimulation (tDCS) applied over the primary motor cortex (M1).\n\nPost-intervention TMS assessments are conducted using the same single- and paired-pulse paradigms to evaluate changes in corticospinal excitability and intracortical and sensorimotor circuits following the combined physical inactivity and anodal tDCS intervention.",[20,14,15],"Behavioral: Physical Inactivity",{"label":22,"type":10,"description":23,"interventionNames":24},"Physical Activity","Participants undergo baseline assessments of corticospinal excitability and intracortical and sensorimotor circuits using transcranial magnetic stimulation (TMS). They then perform 20 minutes of moderate-intensity aerobic exercise on a cycle ergometer at 50% of heart rate reserve, maintaining a cadence of 60 to 70 revolutions per minute (rpm). Immediately after exercise, post-intervention TMS assessments are conducted using the same single- and paired-pulse paradigms to evaluate changes in corticospinal excitability and intracortical and sensorimotor circuits following aerobic exercise alone.",[13,14],[26,32,36,41],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"BEHAVIORAL","Aerobic Exercise","Participants perform 20 minutes of moderate-intensity cycling on a cycle ergometer at 50% of heart rate reserve, maintaining a cadence between 60 and 70 revolutions per minute (rpm).",[22,9],null,{"type":27,"name":33,"description":34,"armGroupLabels":35,"otherNames":31},"Physical Inactivity","Participants remain seated for 20 minutes while watching a silent video of natural waterfall scenes without narration.",[17],{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":31},"DEVICE","Transcranial Magnetic Stimulation","Single- and paired-pulse TMS is applied over the primary motor cortex (M1) to assess corticospinal excitability and intracortical inhibitory and facilitatory mechanisms and sensorimotor circuit function. Motor evoked potentials (MEPs) are recorded from the abductor pollicis brevis (APB) muscle of the dominant hand.",[22,9,17],{"type":37,"name":42,"description":43,"armGroupLabels":44,"otherNames":31},"transcranial direct current stimulation","Anodal transcranial direct current stimulation (tDCS) is delivered for 20 minutes over the primary motor cortex (M1) at a current intensity of 2mA.",[9,17],[46,51],{"name":47,"role":48,"phone":49,"phoneExt":31,"email":50},"Hervé Devanne, Pr","CONTACT","+33 6 76 32 12 84","herve.devanne@univ-littoral.fr",{"name":52,"role":48,"phone":53,"phoneExt":31,"email":54},"Laurence Jones, MSc","+33 6 11 77 53 23","laurence.jones@etu.univ-littoral.fr",[56],{"facility":57,"status":58,"city":59,"state":60,"zip":61,"country":62,"countryCode":63,"cosmosGeoPoint":64,"geoPoint":69,"contacts":70},"Eurasport","RECRUITING","Loos","Nord","59120","France","FR",{"type":65,"coordinates":66},"Point",[67,68],3.01874,50.60982,{"lat":68,"lon":67},[71],{"name":72,"role":48,"phone":73,"phoneExt":31,"email":74},"Serge Berthoin, PhD","+33 3 74 00 82 02","serge.berthoin@univ-lille.fr",{"type":76,"investigatorFullName":31,"investigatorTitle":31,"investigatorAffiliation":31,"oldNameTitle":31,"oldOrganization":31},"SPONSOR","100626682","influence-of-physical-exercise-on-neuroplasticity-and-sensorimotor-networks-in-older-adults-100626682",false,"NCT07438808","Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults","EXOPLASTIC","Inclusion Criteria:\n\n* Men or women aged 20 to 35 for the younger group and 65 to 80 for the older group.\n* Healthy right-handed or left-handed subjects.\n* Subjects who have signed an informed consent form.\n* Ability to understand spoken and written French to follow study procedures.\n* Subjects affiliated with or beneficiaries of a social security system.\n\nExclusion Criteria:\n\n* History of psychaitric disorders : individuals with mental retardation or severe impairment of cognitive, behavioral, or emotional functions that prevent them from understanding the protocol and signing the informed consent form.\n* Neurological history (epilepsy, stroke, brain or spinal cord surgery, and history of neurological diseases affecting motor skills and sensitivity, such as multiple sclerosis, neurodegenerative diseases such as Parkinson's or Alzheimer's).\n* Inability to give informed consent (e.g., dementia, significant hearing impairment, insufficient language proficiency).\n* Contraindications to TMS and tDCS : uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp skin lesion, high intracranial pressure, cerebrospinal fluid shunt).\n* Presence of a cardiac pacemaker or other implanted electronic medical device.\n* Use of psychotropic drugs.\n* Individuals under legal guardianship or curatorship.\n* Pregnant and breastfeeding women.\n* Inability or recognized contraindication to physical activity.",true,"ALL","20 Years","80 Years",{"count":89,"type":90},66,"ESTIMATED","INTERVENTIONAL",[93],"NA","The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current stimulation (tDCS), and to compare these effects with those observed in young adults.\n\nNormal aging is associated with changes in the central nervous system that can affect motor function, sensorimotor integration, and cortical inhibitory mechanisms. These alterations may reduce the brain's capacity for neuroplasticity, which is essential for motor learning and functional adaptation. Physical exercise has been proposed as a potential strategy to counteract age-related decline in neuroplasticity.\n\nIn this study, healthy young and older adults will participate in three experimental sessions. Participants will complete two experimental conditions in a randomized crossover design: (1) aerobic exercise followed by transcranial direct current stimulation (tDCS), and (2) physical inactivity followed by tDCS and a third session will assess the effects of exercise alone. Moderate aerobic exercise will consist of 20 minutes of cycling on an ergometer.\n\nCorticospinal excitability and intracortical and sensorimotor circuit function will be assessed using transcranial magnetic stimulation (TMS) before and after each intervention. Neuroplasticity will be evaluated by measuring changes in motor evoked potentials recorded from a hand muscle of the dominant side.\n\nThe primary objective is to determine whether aerobic exercise enhances tDCS-induced plasticity, and whether this enhancement differs between young and older adults. Secondary objectives include evaluating age-related differences in intracortical inhibitory and facilitatory mechanisms and sensorimotor integration processes.\n\nBy improving understanding of how exercise interacts with brain stimulation to modulate motor cortex plasticity, this study may help inform strategies aimed at preserving motor function and functional independence in aging populations.",[96,9,17],"tDCS",[96,98,38,99,28],"Corticospinal Excitability","Physical Exercise","2026-02-22",{"date":102,"type":103},"2026-02-27","ACTUAL",{"date":105,"type":90},"2026-02-04",{"date":107,"type":90},"2026-07",{"name":5,"class":6},1]