[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639378":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":30,"responsibleParty":52,"collaborators":54,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":68,"acronym":69,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":19,"enrollmentInfo":74,"targetDuration":19,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":33,"whyStopped":19,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Colorado State University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Single-arm","EXPERIMENTAL","All participants will receive a single dose of the blueberry intervention to characterize pharmacokinetic profiles of polyphenol metabolites.",[13],"Other: Freeze-dried blueberry powder beverage",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"Freeze-dried blueberry powder beverage","Participants will consume a single oral dose of a standardized blueberry beverage prepared with 22 g of freeze-dried blueberry powder reconstituted in approximately 480 mL of distilled water. The beverage will be consumed in its entirety at the start of the test visit following an overnight fast. This dose is selected to provide a defined quantity of blueberry-derived polyphenols for pharmacokinetic assessment. No additional interventions or comparator treatments will be administered.",[9],null,[21,26],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Tiffany Weir, PhD","CONTACT","(970) 491-4631","tiffany.weir@colostate.edu",{"name":27,"role":23,"phone":28,"phoneExt":19,"email":29},"Jenny Whittington, MS","(970) 310-6843","ijwhitt@rams.colostate.edu",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Colorado State University; Food and Nutrition Clinical Research Laboratory; Gifford Building Room 216; 502 West Lake Street, Fort Collins, CO 80523","RECRUITING","Fort Collins","Colorado","80523","United States","US",{"type":40,"coordinates":41},"Point",[42,43],-105.08442,40.58526,{"lat":43,"lon":42},[46,48,50],{"name":27,"role":23,"phone":47,"phoneExt":19,"email":29},"970-310-6843",{"name":22,"role":23,"phone":19,"phoneExt":19,"email":49},"Tiffany.weir@colostate.edu",{"name":22,"role":51,"phone":19,"phoneExt":19,"email":19},"PRINCIPAL_INVESTIGATOR",{"type":53,"investigatorFullName":19,"investigatorTitle":19,"investigatorAffiliation":19,"oldNameTitle":19,"oldOrganization":19},"SPONSOR",[55,57,60,62],{"name":56,"class":6},"Florida State University",{"name":58,"class":59},"National Center for Complementary and Integrative Health (NCCIH)","NIH",{"name":61,"class":6},"University of Utah",{"name":63,"class":6},"King's College London","100639378","influence-of-the-gut-microbiome-on-blueberry-polyphenol-metabolites-100639378",false,"NCT07607158","Influence of the Gut Microbiome on Blueberry Polyphenol Metabolites","BlueBIOME","Inclusion Criteria:\n\n* Healthy adults ≥18 years of age\n* Able and willing to provide informed consent\n* Willing and able to adhere to all study procedures and visit requirements\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Pregnant or breastfeeding\n* Presence of chronic diseases, including but not limited to cardiovascular disease, diabetes, cancer, kidney, liver, gastrointestinal, or pancreatic disease\n* Use of medications for chronic diseases that may interfere with study outcomes\n* Any condition known to negatively impact nutrient absorption (e.g., inflammatory bowel disease, celiac disease, gastroparesis)\n* Anemia (hemoglobin \\\u003C13.5 g\u002FdL in men or \\\u003C12.0 g\u002FdL in women)\n* Body mass index (BMI) ≤18.5 kg\u002Fm²\n* Use of antibiotics within the past 2 months\n* Recent blood draw within 1 week prior to study participation\n* Currently participating in another research study involving a diet or exercise intervention\n* Known allergy or contraindication to blueberry products or study procedures\n* Unwilling or unable to comply with study requirements",true,"ALL","18 Years",{"count":75,"type":76},125,"ESTIMATED","INTERVENTIONAL",[79],"NA","The objective of this study is to determine whether inter-individual differences in the gut microbiome influence exposure to blueberry polyphenol metabolites. We will use pharmacokinetics of blueberry polyphenols after an acute blueberry exposure to group individuals into \"metabotypes\", groups of individuals based on similarity in their metabolite profiles. We will then use multi-omic approaches to determine whether the gut microbiome predicts an individual's metabotype.",[82,83],"Microbiome Analysis","Metabolomics",[85,86,87,88,89],"Microbiome","Polyphenols","Metabotype","Pharmacokinetics","Metabolites","2026-05-19",{"date":92,"type":93},"2026-05-26","ACTUAL",{"date":95,"type":93},"2026-01-27",{"date":97,"type":76},"2028-01-01",{"name":5,"class":6},1]