[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622776":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":24,"locations":30,"responsibleParty":51,"collaborators":10,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":10,"studyType":66,"phases":10,"briefSummary":67,"conditions":68,"keywords":10,"overallStatus":33,"whyStopped":10,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"Sheffield Children's NHS Foundation Trust","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Septic Arthritis",null,"Patients are stratified into two arms. If the participant is admitted with septic arthritis they will be prepared to be taken to theatres to have routine surgery. After the patients is in the theatre under general anaesthesia and immediately prior to surgery the research team will perform the study intervention. This is using a High Resolution Thermal Imaging camera to take an image of the infected area.",[13],"Device: High Resolution Thermal Imaging",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-Emergent Musculoskeletal Infection","Patients are stratified into two arms. If the participant is admitted with a non emergent MSK infection, the patient will be prepared to have an MRI scan. Immediately prior to the MRI scan, the research team will perform the study intervention. This is using a High Resolution Thermal Imaging camera to take an image of the infected area.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DEVICE","High Resolution Thermal Imaging","A HRTI camera is a non-invasive medical device that will be utilised on patients that present in ED with an MSK infection. The goal of this intervention is to answer the following:\n\nCan combined HRTI and blood tests provide a higher diagnostic reliability than HRTI on its own? Can combined HRTI and artificial intelligence (AI) provide a timelier (as compared to existing modalities) detection of bone, joint and soft tissue infection thus allowing a more effective treatment? What are patients views and feedback for the new HRTI method?",[15,9],[25],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Sanjeev Madan","CONTACT","+44 0114 271 7000","s.madan@sheffield.ac.uk",[31],{"facility":32,"status":33,"city":34,"state":35,"zip":36,"country":37,"countryCode":38,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Sheffield Children's NHS Foundatin Trust","RECRUITING","Sheffield","South Yorkshire","S10 2TH","United Kingdom","UK",{"type":40,"coordinates":41},"Point",[42,43],-1.4659,53.38297,{"lat":43,"lon":42},[46,49],{"name":47,"role":27,"phone":28,"phoneExt":10,"email":48},"Research and Development Manager","scn-tr.research.governance@nhs.net",{"name":26,"role":50,"phone":10,"phoneExt":10,"email":10},"PRINCIPAL_INVESTIGATOR",{"type":52,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622776","infrared-thermography-for-diagnosis-of-musculoskeletal-infections-100622776",false,"NCT07388017","Infrared Thermography for Diagnosis of Musculoskeletal Infections","High Resolution Thermographic Imaging as a Diagnostic Aid in Paediatric Infections of Bones, Joints, and Soft Tissues","Inclusion Criteria:\n\n* Children and young people from neonates to 15 years of age:\n* With clinical suspicion of a primary MSK infection (irrespective of location or aetiology), as defined by presenting symptoms, physical examination and bloodwork performed by a qualified clinician.\n* Presenting to Sheffield Children's Hospital via A\\&E or referral from another hospital.\n* Who are able to interpret the information given in the information sheet\u002Fassent form on paper in English (with the exception of children under the age of 3 years who are not required to assent.)\n* With at least 1 competent legal guardian who is capable of legally consenting, and interpreting the information given in the information sheet in English.\n* Where a medical doctor involved in their care has agreed that their participation in the study will not negatively impact on their treatment outcome\n\nExclusion Criteria:\n\n* \\- Have a secondary MSK infection.\n* Are severely ill or need urgent\u002Fcritical attention or have comorbid conditions that will complicate their care, as decided by a medical doctor involved in their treatment.\n* Patients with conditions including but not limited to leukaemia, hyper\u002Fhypothyroidism, diabetes mellitus or any other condition that affects their basal metabolic rate\u002Fbody temperature.\n* Amputees where the amputated region is contralateral to the region of suspected infection.\n* Have received an a priori diagnosis or have already undergone any investigation. This includes patients admitted for a recurrence\u002Fexacerbation of recently diagnosed MSK infection.\n* Any patient where the medical team responsible for their treatment raises concerns that HRTI could negatively impact their treatment outcome.\n* The patient, or their legal guardian(s) do not consent or assent\u002Fwithdraw consent or assent\u002F or are not able to consent or assent for any reason. (Eg. The patient\u002Fguardian(s) are non-English speakers or have disabilities impairing their understanding of the study.)","ALL","0 Years","15 Years",{"count":64,"type":65},30,"ESTIMATED","OBSERVATIONAL","This is a pilot proof of feasibility study to explore the efficacy of High Resolution Infrared Thermographic Imaging (HRTI) to assist with the detection of musculoskeletal infections in children. In HRTI, a sensitive thermal camera is used to capture the temperature profile of the suspected infected body region in the form of images. In this study, a 10-second video will be recorded to allow dynamic monitoring. The resulting video will be processed and interpreted to determine whether there is a musculoskeletal infection.\n\nBone, joint and soft tissue infections can be caused by bacteria which can enter the body through accidental injuries, or because of surgery or implants. Once in the body, they circulate through the bloodstream until they reach a bone, joint, or muscle, multiply and cause infection. These conditions can cause significant complications in children and adults and can even result in death if untreated.\n\nInfections of the bone, called osteomyelitis can inhibit bone growth in children. As a result, children who have suffered from osteomyelitis may require extensive treatment later in childhood. While osteomyelitis accounts for only 1% of childhood hospital admissions, its incidence in children has increased in recent decades. This is associated with an increase in the prevalence of antibiotic resistant bacteria such as MRSA.\n\nInfections of the joint, called septic arthritis, is an emergency condition that requires prompt diagnosis and treatment. Long delays in diagnosis and surgical drainage of the joint may lead to irreversible damage to the cartilage and bone destruction.\n\nThere is currently a need for improved technologies to screen for and monitor bone, joint, and soft tissue infections. Plain radiographs appear normal in the first 7 to 10 days of osteomyelitis. Magnetic resonance imaging (MRI) is the most sensitive modality for diagnosing osteomyelitis. However, MRI scans are costly their accessibility is limited, plus the scan can take 30 minutes to perform. As the child needs to be still during the scan, sedation is required.\n\nInfrared thermal imaging is a harmless, cost effective and rapid scanning method that has proven industrial applications such as condition monitoring of machineries and fault findings. There has also been extensive interest in utilising and this technology for medical diagnosis and monitoring. This study builds on our earlier work that used HRTI to detect inflammation in the abdomen in infants. This technology may allow timelier and more cost-effective diagnosis of the condition. Sheffield Children's Hospital and Sheffield Hallam University collaborate in conducting the study.\n\nThe study will involve recruiting 30 patients at Sheffield Children's Hospital with suspected infection of either bone, joint or soft tissue. They will have their HRTI recorded and processed to follow up the study's research questions. The findings from the study will not alter the routine medical treatments of the patients and participation is voluntary.",[69,9,70],"Musculoskeletal Infection","Osteomyelitis\u002FSeptic Arthritis","2026-01-27",{"date":73,"type":74},"2026-02-04","ACTUAL",{"date":76,"type":74},"2025-02-17",{"date":78,"type":65},"2026-01-31",{"name":5,"class":6},1]