[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628901":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":54,"collaborators":58,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":24,"enrollmentInfo":70,"targetDuration":24,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":82,"overallStatus":86,"whyStopped":24,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Kaiser Permanente","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention Medical Center - Notification Group","ACTIVE_COMPARATOR","In medical centers assigned to the intervention group, physicians of eligible patients will be sent a one-time notification with information about their patient's iron deficiency, current KPNC and national clinical practice guidelines about IV iron therapy, and available IV iron formulations and recommended dosages.",[13],"Other: Notification Group",{"label":15,"type":10,"description":16,"interventionNames":17},"Control Medical Center - No Notification Group","In medical centers assigned to the control group, physicians of eligible patients will NOT be sent information about their patients or current KPNC and national clinical practice guidelines about the use of IV iron therapy in the setting of heart failure.",[18],"Other: No Notification Group",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Notification Group","In medical centers assigned to the intervention group within the INITIATE-HF study, physicians of eligible patients with HF and iron deficiency will be sent information from current KPNC and national guidelines about IV iron therapy.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"No Notification Group","In medical centers assigned to the control group, physicians will not receive information about current guidelines about the use of IV iron (i.e., usual care).",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Alan S Go, MD","CONTACT","510-821-0904","alan.s.go@kp.org",[36],{"facility":37,"status":24,"city":38,"state":39,"zip":40,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Division of Research","Pleasanton","California","94588","United States","US",{"type":44,"coordinates":45},"Point",[46,47],-121.87468,37.66243,{"lat":47,"lon":46},[50],{"name":51,"role":32,"phone":52,"phoneExt":24,"email":53},"Elisha A Garcia, BS","415--579-5301","elisha.a.garcia@kp.org",{"type":55,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Alan Go","Associate Director, Division of Research",[59],{"name":60,"class":6},"Garfield Memorial Fund","100628901","infusing-needed-iron-to-target-insufficiency-in-adults-treated-for-evidence-of-heart-failure-100628901",false,"NCT07467668","Infusing Needed Iron to Target Insufficiency in Adults Treated for Evidence of Heart Failure","INITIATE-HF","Inclusion Criteria:\n\nAdults (age \\>18 years); Diagnosed heart failure with most recent left ventricular ejection fraction \\\u003C50%; Hospitalized for any reason for the index admission; Documented iron deficiency defined as TSAT \\\u003C20% during the index hospitalization; At least 6 months of health plan coverage and prescription drug benefit before admission\n\nExclusion Criteria:\n\nA documented allergy to IV iron in the Kaiser Permanente Northern California (KPNC) electronic health record (EHR) system; A history of hemochromatosis (i.e., iron overload) based on KPNC EHR data; End-stage kidney disease (defined as receiving chronic dialysis or a prior kidney transplant) or advanced chronic kidney disease (i.e., estimated glomerular filtration rate \\[eGFR\\] \\\u003C30 mL\u002Fmin\u002F1.73 m2) based on most recent pre-admission outpatient laboratory results or the KPNC regional End-Stage Kidney Disease Treatment Registry; Serum ferritin \\>300 ng\u002FmL based on KPNC EHR data; Diagnosed with metastatic cancer and\u002For receiving systemic chemotherapy based on KPNC EHR data; Institutionalized (e.g., prison) and\u002For receiving palliative care per KPNC EHR data","ALL","18 Years",{"count":71,"type":72},3000,"ESTIMATED","INTERVENTIONAL",[75],"NA","The INITIATE-HF study is a cluster randomized controlled trial that aims to find out if reminding doctors about treatment guidelines for iron deficiency in adults with heart failure who are hospitalized and have evidence of iron deficiency changes the subsequent use of intravenous (IV) iron.\n\nTwo groups of hospitalized adult patients with known heart failure and iron deficiency will be compared:\n\n* Group 1 will include doctors who receive a notification with their patient's iron storage test results and guideline recommendations related to the use of IV iron.\n* Group 2 will include doctors who do not receive this notification and continue with usual standard of care.\n\nThe study will measure if this provider-facing notification affects physician use of recommended IV iron treatment in eligible patients with heart failure, left ventricular ejection fraction less than 50%, and iron deficiency. Secondarily, if there is an increased use of IV iron observed in the intervention group, this study will evaluate whether there are differential health outcomes (i.e., fewer subsequent hospital visits and lower risk of death) of patients whose providers were assigned to the intervention group.",[78,79,80,81],"Iron Deficiency (ID)","Heart Failure","Heart Failure and Reduced Ejection Fraction","Heart Failure and Mildly Reduced Ejection Fraction",[83,84,85],"IV iron","iron deficiency","heart failure","NOT_YET_RECRUITING","2026-03-11",{"date":89,"type":90},"2026-03-12","ACTUAL",{"date":92,"type":72},"2026-03-09",{"date":94,"type":72},"2028-12-31",{"name":5,"class":6},1]