[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100626070":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":35,"responsibleParty":50,"collaborators":52,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":12,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":81,"whyStopped":12,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Washington","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Study 1, A co-twin control study of habitual diet","NO_INTERVENTION","Monozygotic twin pairs with differential habitual diet practices will undergo measurements including body composition, and MRI measures of hepatic adiposity and neuroinflammation.",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Study 2, A twin study of controlled diet","EXPERIMENTAL","Monozygotic twin pairs will be provided an assigned diet for 14-days.",[18],"Behavioral: Diet modification",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"BEHAVIORAL","Diet modification","Participants will be provided all meals for a 14-day period. For 7 of the days, meals will be 150% of estimated daily caloric needs and for the other 7 days, meals will be low in calories, consistent with recommendations for weight loss.",[14],[26],{"name":27,"affiliation":5,"role":28},"Ellen Schur, MD, MS","PRINCIPAL_INVESTIGATOR",[30],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},"INTERACT Study","CONTACT","206-616-6360","interactstudy@uw.edu",[36],{"facility":5,"status":12,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"Seattle","Washington","98109","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-122.33207,47.60621,{"lat":46,"lon":45},[49],{"name":31,"role":32,"phone":33,"phoneExt":12,"email":34},{"type":28,"investigatorFullName":27,"investigatorTitle":51,"investigatorAffiliation":5,"oldNameTitle":12,"oldOrganization":12},"Professor: School of Medicine",[53],{"name":54,"class":55},"National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","NIH","100626070","inherited-and-environmental-risks-acting-on-body-weight-100626070",false,"NCT07430852","Inherited and Environmental Risks Acting on Body Weight","Genetic and Environmental Contributions to Obesity Pathogenesis","INTERACT","Inclusion Criteria:\n\n* Age 20-45 years\n* Differs in habitual diet from co-twin (study 1).\n* Willing to undergo 7-day overfeeding and hypocaloric feeding periods (study 2)\n* Member of the Washington State Twin Registry\n\nExclusion Criteria:\n\n* History of bariatric surgery or active participation in weight-loss program\n* Major medical or neurological disorder (e.g., diabetes, multiple sclerosis)\n* Known gallbladder disease, anemia, impaired thyroid, kidney or liver function or hypertriglyceridemia (\\>350 mg\u002Fdl) (study 2)\n* Current use of weight-loss medications or other medications known to alter appetite (e.g., atypical anti-psychotics)\n* High levels of vigorous physical activity (\\>300 min.\u002Fweek)\n* Pregnancy, menopause, or breastfeeding\n* Individuals with severe food allergies and dietary restrictions (e.g., vegan\u002Fvegetarian, gluten-free, others) (study 2)\n* Co-twin unwilling or unable to participate\n* MRI contraindication (e.g., implanted metal, claustrophobia)\n* Lifetime eating disorder\n* Current smoking or heavy alcohol use (≥ 2 drinks per day for females and ≥ 3 drinks per day for males)\n* BMI \\> 45 kg\u002Fm2 (study 1)\n* BMI \\> 35 kg\u002Fm2 (study 2)\n* Weight \\> 350 pounds or determined to be safe by MRI tech (MRI limit)\n* Inability to participate in a controlled diet program (study 2) or undergo other study procedures\n* Non-English speaking-or-reading individuals",true,"ALL","20 Years","45 Years",{"count":69,"type":70},110,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this research is to investigate genetic and environmental factors that contribute to obesity through brain inflammation. The main questions are 1) if identical twins, who differ in food consumption habits, have differences in adiposity markers and brain inflammation and 2) if signs of brain inflammation in response to a specific diet is modified by genetics.",[76,77],"Genetics","Obesity",[79,80],"Gliosis","Eating patterns","NOT_YET_RECRUITING","2026-02-18",{"date":84,"type":85},"2026-02-24","ACTUAL",{"date":87,"type":70},"2026-09-01",{"date":89,"type":70},"2030-04-30",{"name":5,"class":6},1]