[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100451456":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":12,"centralContacts":16,"locations":25,"responsibleParty":69,"collaborators":71,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":7,"maxAge":7,"enrollmentInfo":85,"targetDuration":7,"studyType":88,"phases":7,"briefSummary":89,"conditions":90,"keywords":7,"overallStatus":28,"whyStopped":7,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":102},{"fullName":5,"class":6},"Imperial College London","OTHER",null,[9],{"type":6,"name":10,"description":11,"armGroupLabels":7,"otherNames":7},"Patients with inherited cardiac condition, onset \u003C16 years old and Parents","Patients with a confirmed diagnosis of an inherited cardiac condition, onset \\\u003C16 years old and Parents will have samples that undergo whole genome sequencing and biomarker analysis",[13],{"name":14,"affiliation":5,"role":15},"James Ware","PRINCIPAL_INVESTIGATOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":7,"email":21},"Katherine Josephs","CONTACT","0207 594 9459","k.josephs@imperial.ac.uk",{"name":23,"role":19,"phone":24,"phoneExt":7,"email":7},"Chief Investigator","0330 128 2294",[26,46,56],{"facility":27,"status":28,"city":29,"state":7,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Royal Brompton Hospital","RECRUITING","London","SW3 6NP","United Kingdom","UK",{"type":34,"coordinates":35},"Point",[36,37],-0.12574,51.50853,{"lat":37,"lon":36},[40,44],{"name":41,"role":19,"phone":42,"phoneExt":7,"email":43},"Jemilat Orlandy","07756223595","j.orlandy@rbht.nhs.uk",{"name":45,"role":15,"phone":7,"phoneExt":7,"email":7},"Piers Daubeney, Professor",{"facility":47,"status":28,"city":29,"state":7,"zip":7,"country":31,"countryCode":32,"cosmosGeoPoint":48,"geoPoint":50,"contacts":51},"Great Ormond Street Hospital for Children",{"type":34,"coordinates":49},[36,37],{"lat":37,"lon":36},[52,55],{"name":53,"role":19,"phone":7,"phoneExt":7,"email":54},"Angharad Roberts, Dr","angharad.roberts@imperial.ac.uk",{"name":53,"role":15,"phone":7,"phoneExt":7,"email":7},{"facility":57,"status":28,"city":58,"state":7,"zip":59,"country":31,"countryCode":32,"cosmosGeoPoint":60,"geoPoint":64,"contacts":65},"Harefield Hospital","Uxbridge","UB9 6JH",{"type":34,"coordinates":61},[62,63],-0.48211,51.5489,{"lat":63,"lon":62},[66,67],{"name":41,"role":19,"phone":42,"phoneExt":7,"email":43},{"name":68,"role":15,"phone":7,"phoneExt":7,"email":7},"Andres Rico-Armada, Dr",{"type":70,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[72,74],{"name":73,"class":6},"Royal Brompton & Harefield NHS Foundation Trust",{"name":75,"class":6},"Great Ormond Street Hospital for Children NHS Foundation Trust","100451456","inherited-cardiac-conditions-in-kids-100451456",false,"NCT05158738","Inherited Cardiac cONditions In Kids","Inherited Cardiac cONditions In Kids: Understanding the Genetics and Outcomes of Paediatric Inherited CardiacConditions","ICONIK","Inclusion Criteria:\n\n* Males or females with a confirmed diagnosis of childhood onset (\\\u003C16 years) PCM\n* Males or females with childhood onset (\\\u003C16 years) of a rare inherited cardiac condition likely to be a monogenic condition\n* Capacity for parents to provide informed consent\n* Genotype negative following local standard diagnostic ICC gene panel\n* Family members of patients with ICC, both affected and unaffected\n\nExclusion Criteria:\n\n* Parents who lack capacity to provide consent on behalf of their children\u002Fthemselves\n* Onset over 16 years\n* Significant teratogen exposure (including maternal diabetes) likely to contribute to cardiac dysfunction (following discussion with Cardiologist)\n* Significant coronary heart disease likely to contribute to cardiac dysfunction (following discussion with Cardiologist)\n* Other secondary causes of cardiac dysfunction likely to explain the phenotype of the patient\n* Patients with a confirmed genetic diagnosis (patients with variants of uncertain significance are not excluded).","ALL",{"count":86,"type":87},300,"ESTIMATED","OBSERVATIONAL","All patients with heart disease should have the opportunity to participate in research into their condition, to advance knowledge and treatment. The investigators have built an online registry and database - The Heart Hive - to connect research-willing participants (with heart muscle disease) with active researchers and projects. Participants enrol and upload their own data through the website.This study uses The Heart Hive platform to study cardiomyopathies - heart muscle disease. These are progressive diseases, and there is a need to better understand what factors affect the chances of developing cardiomyopathy, and how the condition progresses. The study will collect information about participants diagnosis, DNA for genetic analysis, and then follow participants' clinical progress. The study will identify genetic variants that cause cardiomyopathy, and determine which specific genetic or environmental factors predict disease severity, progression and response to treatment, with an overall objective of identifying new and personalised treatments for patients with this disease.",[91,92],"Inherited Cardiac Conditions","Cardiovascular Diseases","2025-03-03",{"date":95,"type":96},"2025-03-05","ACTUAL",{"date":98,"type":96},"2022-09-01",{"date":100,"type":87},"2026-12-01",{"name":5,"class":6},3]