[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100520489":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":24,"centralContacts":29,"locations":10,"responsibleParty":38,"collaborators":40,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":10,"studyType":60,"phases":10,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":69,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":10},{"fullName":5,"class":6},"University Hospital, Grenoble","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patients",null,"mqMRI and GABA-MRS data will be collected in patients suffering from mesial temporal lobe epilepsy",[13],"Diagnostic Test: mqMRI and GABA-MRS",{"label":15,"type":10,"description":16,"interventionNames":17},"Volunteers","mqMRI and GABA-MRS data will be collected in healthy volunteers",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":10},"DIAGNOSTIC_TEST","mqMRI and GABA-MRS","multiparametric quantitative MRI (mqMRI) and of GABA-edited magnetic resonance spectroscopy (GABA-MRS)",[9,15],[25],{"name":26,"affiliation":27,"role":28},"Philippe Kahane, MD, PhD","University Grenoble Alps","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Lucie Miquel, MSc","CONTACT","+33 4 76 76 63 08","lmiquel@chu-grenoble.fr",{"name":36,"role":32,"phone":10,"phoneExt":10,"email":37},"Emmanuel L Barbier, PhD","emmanuel.barbier@univ-grenoble-alpes.fr",{"type":39,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[41,42],{"name":27,"class":6},{"name":43,"class":44},"Institut National de la Santé Et de la Recherche Médicale, France","OTHER_GOV","100520489","innovative-mri-to-localize-the-epileptic-zone-100520489",false,"NCT06057233","Innovative MRI to Localize the Epileptic Zone","Quantitative MRI and GABA Spectroscopy to Localize the Epileptic Zone","EPI-CATCHER","Inclusion Criteria:\n\n* Patient group\n\n  * Patients aged 18-65 years,\n  * Patients with drug-resistant focal epilepsy,\n  * Patients with MTLE suspicion, with normal MRI or hippocampal sclerosis, and candidate for surgery,\n  * Negative pregnancy test for child-bearing aged woman,\n  * Obtained signed informed consent from patient\n* Reference group\n\n  * Male or female, 18-65 years,\n  * Obtained signed informed consent from participants,\n  * Negative pregnancy test for child-bearing aged woman\n\nExclusion Criteria:\n\n* Patient group\n\n  * Patient without social security system\n  * Inability or unwillingness of the individual to provide written informed consent, according to national regulations.\n  * Impossibility of collecting information on exposure (subjects recently arrived in France, foreign language, etc.),\n  * Contraindication for MRI,\n  * Contraindication for injection of MRI contrast agent (Gd-Chelate),\n  * Evidence on neuroimaging (CT or MRI) of a brain lesion in the same hemisphere as the EZ (tumor, stroke, cerebral edema with midline shift and a clinically significant compression of ventricles, or subarachnoid hemorrhage, or intracerebral parenchymal hematoma (petechial small hemorrhages are NOT a non-inclusion criteria),\n  * Severe leucoariosis\n  * Pre-existing dementia\n  * Pregnant, breastfeeding women\n* Reference group\n\n  * Person who is participating in another therapeutic trial\n  * Person with a psychiatric disorder, an epilepsy, or a brain lesion susceptible to impact the MRI readouts\n  * Person without social security system,\n  * Inability or unwillingness of the individual to provide written informed consent, according to national regulations,\n  * Impossibility of collecting information on exposure (subjects recently arrived in France, foreign language, etc.),\n  * Contraindication for MRI\n  * Contraindication for injection of MRI contrast agent (Gd-Chelate)\n  * Pregnant, breastfeeding woman.",true,"ALL","18 Years","65 Years",{"count":58,"type":59},40,"ESTIMATED","OBSERVATIONAL","The goal of EPI-CATCHER is to outline the clinical potential of multiparametric quantitative MRI (mqMRI) and of GABA-edited magnetic resonance spectroscopy (GABA-MRS), combined with machine learning tools, as imaging biomarkers to localize and delineate the EZ.",[63],"Epilepsy, Temporal Lobe",[65,66,67,68],"MRI","Quantitative","GABA","MRS","NOT_YET_RECRUITING","2024-08-22",{"date":72,"type":73},"2024-08-23","ACTUAL",{"date":75,"type":59},"2024-10",{"date":77,"type":59},"2028-11",{"name":5,"class":6}]