[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561290":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":18,"responsibleParty":37,"collaborators":10,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":43,"sex":49,"minAge":10,"maxAge":10,"enrollmentInfo":50,"targetDuration":53,"studyType":54,"phases":10,"briefSummary":55,"conditions":56,"keywords":61,"overallStatus":21,"whyStopped":10,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},{"fullName":5,"class":6},"Federico II University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"INOCA",null,"Patients presenting with symptoms or signs of myocardial ischemia with non-obstructing coronary artery disease",[13],{"name":14,"role":15,"phone":16,"phoneExt":10,"email":17},"Luigi Di Serafino, MD, PhD","CONTACT","0039 347917374","luigi.diserafino@unina.it",[19],{"facility":20,"status":21,"city":22,"state":23,"zip":24,"country":23,"countryCode":25,"cosmosGeoPoint":26,"geoPoint":31,"contacts":32},"DPT of Advanced Biomedical Sciences","RECRUITING","Naples","Italy","80131","IT",{"type":27,"coordinates":28},"Point",[29,30],14.26811,40.85216,{"lat":30,"lon":29},[33],{"name":34,"role":15,"phone":35,"phoneExt":10,"email":36},"Stefano Cristiano","+300817463075","stefano.cristiano@unina.it",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Luigi Di Serafino","Principal Investigator, Clinical Professor","100561290","inoca-na-a-local-prospective-registry-100561290",false,"NCT06588244","INOCA-NA a Local Prospective Registry","Ischemia in Patients with Non- Obstructive Disease (INOCA) - a Local Prospective Registry (INOCA-Naples)","INOCA-NA","Inclusion Criteria:\n\n* Clinical presentation of chronic ischemic heart dis- ease (IHD), requiring coronary angiography for the diagnosis;\n* Absence of obstructive coronary artery disease (CAD) at coronary angiography;\n* Age \\> 18 years.\n* Ability to provide a valid informed consent to the study procedure at the time of baseline evaluation;\n\nExclusion Criteria:\n\nClinical presentation of acute coronary syndrome (ACS) or cardiogenic shock;\n\n* Presence of obstructive CAD with at least 1 significant coronary artery stenosis, defined as diameterstenosis \\>50% and FFR ≤0.80 (or iFR\u002FRFR ≤0.89);\n* Previous coronary artery bypass grafting (CABG);\n* Left ventricular systolic dysfunction, defined as ejection fraction (EF) \\<40%;\n* Severe valvular heart disease;\n* Pregnant or breastfeeding women\n* Known hypersensitivity or contraindication to any of the drugs used for coronary physiology testing (adenosine, nitrates, acetylcholine)\n* Inability or unwillingness to provide a valid in- formed consent to the study procedure at the time of baseline evaluation.","ALL",{"count":51,"type":52},250,"ESTIMATED","1 Year","OBSERVATIONAL","The present study has the following objectives:\n\n1. To investigate the prevalence of INOCA in patients referring for a clinically indicated coronary angiography (CA) c\u002Fo Division of Cardiology - Federico II University Hospital;\n2. To stratify in INOCA endotypes patients according to the presence or absence of alternative (i.e. non obstructive CAD) causes of myocardial ischemia detected during CA clinically indicated through physiology tests;\n3. to implement a stratified therapy in these patients considering the different INOCA endotypes and evaluate the impact on angina class and quality of life as well as cardiac hospitalization and coronary revascularization during 5 year follow up",[57,58,59,60],"Ischemia, Myocardial","Non-Obstructive Coronary Atherosclerosis","Microcirculatory Status","Coronary Microvascular Dysfunction (CMD)",[9,62,63],"CMD","VSA","2025-03-12",{"date":66,"type":67},"2025-03-17","ACTUAL",{"date":69,"type":67},"2024-09-19",{"date":71,"type":52},"2027-09-01",{"name":5,"class":6},1]