[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100433483":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":10,"centralContacts":23,"locations":29,"responsibleParty":57,"collaborators":10,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":10,"eligibilityCriteria":65,"healthyVolunteers":61,"sex":66,"minAge":67,"maxAge":10,"enrollmentInfo":68,"targetDuration":10,"studyType":71,"phases":10,"briefSummary":72,"conditions":73,"keywords":78,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Nantes University Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Patient with nephrotic syndrome idiopathic",null,"nephrotic INS patients in primary visit: harvesting of 27.5 ml supplementary blood, 40 mlurine and feces at inclusion visit and at 3 months. No intervention, no treatment administration other than usual\u002Froutine INS treatment.",[13],"Other: Measurement of blood immune populations and microbiota distribution.",{"label":15,"type":10,"description":16,"interventionNames":17},"Patient with nephrotic syndrome no idiopathic, IgA or GEM type or other glomerulopathy","At least 10 NS no idipathic patients: harvesting of 27.5 ml supplementary blood, 40 ml urine and feces at inclusion visit and at 3 months. No intervention, no treatment administration other than usual\u002Froutine care treatment.",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":10},"Measurement of blood immune populations and microbiota distribution.","Measurement of peripheral cell populations by spectral cytometry and in parallel, sequencing of intestinal and urinary bacterial 16S RNA of each patient.",[9,15],[24],{"name":25,"role":26,"phone":27,"phoneExt":10,"email":28},"Christophe Masset","CONTACT","+33 2 76 64 39 61","christophe.masset@chu-nantes.fr",[30,43],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":10},"RECRUITING","Nantes","Loire-Atlantique","44093","France","FR",{"type":38,"coordinates":39},"Point",[40,41],-1.55336,47.21725,{"lat":41,"lon":40},{"facility":44,"status":31,"city":45,"state":10,"zip":46,"country":35,"countryCode":36,"cosmosGeoPoint":47,"geoPoint":51,"contacts":52},"Departemental Hospital Center","La Roche-sur-Yon","85925",{"type":38,"coordinates":48},[49,50],-1.42757,46.66974,{"lat":50,"lon":49},[53],{"name":54,"role":26,"phone":55,"phoneExt":10,"email":56},"Awena LEFUR","0251446161","awena.lefur@ght85.fr",{"type":58,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100433483","ins-b-cells-and-microbiota-100433483",false,"NCT04924712","INS, B Cells and Microbiota","Controlled Multicenter Epidemiological Study of Peripheral Leukocyte Populations and Microbiota in Patients With Idiopathic Nephrotic Syndrome (INS)","Inclusion Criteria :\n\n* Patient treated in participating centers\n* In nephrotic attack, defined biologically by:\n\nProteinuria \\> 3g 24h or A proteinuria\u002Fcreatinuria ratio \\> 3 or Defined at the discretion of the clinician\n\nNon inclusion Criteria :\n\n* Patient with a history of NIS flare-ups resistant to corticosteroid therapy\n* Patient treated with immunosuppressant\n* Patient treated with corticosteroids \\> 10 mg\u002Fd\n* Weight \\\u003C50 kg\n* Pregnant woman\n* Patient under guardianship \u002F curatorship","ALL","12 Years",{"count":69,"type":70},30,"ESTIMATED","OBSERVATIONAL","Idiopathic nephrotic syndrome (NIS) is a clinical entity defined by the association of selective albuminuria, hypoalbuminemia, and nonspecific glomerular lesions (lesions minimal glomerular (LGM) or segmental and focal hyalinosis (HSF). The complication of this kidney disease is the progression towards chronic renal failure and in case of kidney transplantation, its immediate recurrence on the graft . The origin of this syndrome is unknown but a number of clinical observations tend to show an involvement of immune system. A link has been highlighted between atopy, diet and nephrotic flare-ups. The speed of recurrence of this initial disease on the graft and the observation of remissions obtained after treatment by plasma exchange or immunoadsorptions support the presence of a pathogenic plasma factor. Anti-CD20 treatments depleting B lymphocytes has made it possible to favorably treat a number of patients. Dysfunction of regulatory T cells has also been shown in SNI patients. This modification seems linked to allergies and could be due to an aberrant microbiota. The hypothesis of causality between dysbiosis, alteration lymphocyte and triggering of an SNI was mentioned recently. Two studies have shown intestinal dysbiosis in pediatric SNI\u002FLGM, with reduction of T circulating regulators",[74,75,76,77],"Microbiota","B-lymphocytes","Glomerulosclerosis","T-lymphocytes",[79,80,74,81,82],"Idiopathic Nephrotic Syndrome","Focal Segmental Glomerulosclerosis","B Lymphocytes","Regulatory T cells","2026-02-27",{"date":85,"type":86},"2026-03-03","ACTUAL",{"date":88,"type":86},"2022-01-18",{"date":90,"type":70},"2027-01-18",{"name":5,"class":6},2]