[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100577389":3},{"organization":4,"armGroups":7,"interventions":16,"overallOfficials":31,"centralContacts":36,"locations":43,"responsibleParty":59,"collaborators":22,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":65,"acronym":66,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":22,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":82,"overallStatus":46,"whyStopped":22,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Erasme University Hospital","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Glioma patient","EXPERIMENTAL","As compared to the pre-surgical evaluation that brain tumor patients routinely undergo in our institution, patients are asked to undergo some additional examinations.",[13,14,15],"Diagnostic Test: Functional MRI","Diagnostic Test: FDG-PET","Diagnostic Test: Structural MRI",[17,23,27],{"type":18,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"DIAGNOSTIC_TEST","Functional MRI","11 minutes of Functional MRI alternating breathing Air-Room and gaz mix (5%CO2 21%O2 74%N2).\n\nAll procedure are acquired simultaneously on a single acquisition on the PET\u002FMRI camera in the institution.",[9],null,{"type":18,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"FDG-PET","Some patients who did not benefit from a FDG-PET in their clinical evaluation or more than 1 month before the inclusion in the present study will be ask to also undergo a brain FDG-PET , the dose is set at 2 Mega becquerel per Kg.\n\nAll procedure are acquired simultaneously on a single acquisition on the PET\u002FMRI camera in the institution.",[9],{"type":18,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Structural MRI","Patient will benefit Different anatomical sequence of acquisition listed here : T1 , T1 with contrast agent (gadovist) , T2 flair , T2 and DSC (Dynamic susceptibility contrast) , and Time Of Flight .\n\nAll procedure are acquired simultaneously on a single acquisition on the PET\u002FMRI camera in the institution.",[9],[32],{"name":33,"affiliation":34,"role":35},"Xavier De Tiège, MD,PhD","Laboratoire de Neuroanatomie et Neuroimagerie translationnelles Université Libre de Bruxelles","STUDY_CHAIR",[37],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},"Thibault Vanbutsele","CONTACT","25558167","+32","thibault.vanbutsele@hubruxelles.be",[44],{"facility":45,"status":46,"city":47,"state":22,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"HUB-Erasme Hospital","RECRUITING","Brussels","1060","Belgium","BE",{"type":52,"coordinates":53},"Point",[54,55],4.34878,50.85045,{"lat":55,"lon":54},[58],{"name":38,"role":39,"phone":40,"phoneExt":41,"email":42},{"type":60,"investigatorFullName":22,"investigatorTitle":22,"investigatorAffiliation":22,"oldNameTitle":22,"oldOrganization":22},"SPONSOR","100577389","insights-into-the-pathophysiology-of-neurovascular-uncoupling-in-patients-with-brain-lesions-100577389",false,"NCT06797661","Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients with Brain Lesions.","NVUCVR","Inclusion Criteria:\n\n* patients in the study include prior imaging showing a potentially resectable intra-cerebral mass lesion. Patient has to be included before surgery, chemotherapy and radiation\n\nExclusion Criteria:\n\n* previous brain surgery\n* respiratory failure\n* Asthma\n* Claustrophobia\n* Previous adverse reaction to gadovist (contrast agent)\n* Pregnancy and Breath feeding\n* Diabetes (type I and II)","ALL","18 Years","90 Years",{"count":72,"type":73},40,"ESTIMATED","INTERVENTIONAL",[76],"NA","Neurovascular uncoupling (NVU) represents a major source of potential bias for the identification of eloquent brain regions through activation procedures in blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI).\n\nSame region shows proper pattern in glucose metabolism in victiny of brain lesions, investigated with positron emitted tomography with radiolabeled glucose (PET-FDG) This research project aims at investigating the mechanisms of NVU by using a multimodal noninvasive imaging approach in neurosurgical patients.",[79,80,81],"Glioblastoma","Glioma","Astrocytoma",[83],"Primary brain tumor","2025-02-17",{"date":86,"type":87},"2025-02-19","ACTUAL",{"date":84,"type":87},{"date":90,"type":73},"2026-12-31",{"name":5,"class":6},1]