[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100474571":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":24,"centralContacts":28,"locations":34,"responsibleParty":51,"collaborators":54,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":24,"eligibilityCriteria":64,"healthyVolunteers":65,"sex":66,"minAge":67,"maxAge":68,"enrollmentInfo":69,"targetDuration":24,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":24,"overallStatus":36,"whyStopped":24,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Florida State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"High-resistance inspiratory muscle strength training","ACTIVE_COMPARATOR","Participants will perform high-resistance inspiratory muscle strength training on a daily basis for eight weeks using a handheld device that produces resistance that increases the effort of breathing in.",[13],"Device: High-resistance inspiratory muscle strength training",{"label":15,"type":16,"description":17,"interventionNames":18},"Very-low resistance inspiratory muscle strength training","SHAM_COMPARATOR","Participants will perform very-low-resistance inspiratory muscle strength training on a daily basis for eight weeks using a handheld device that produces resistance that increases the effort of breathing in.",[19],"Device: Very-low-resistance inspiratory muscle strength training",[21,25],{"type":22,"name":9,"description":11,"armGroupLabels":23,"otherNames":24},"DEVICE",[9],null,{"type":22,"name":26,"description":17,"armGroupLabels":27,"otherNames":24},"Very-low-resistance inspiratory muscle strength training",[15],[29],{"name":30,"role":31,"phone":32,"phoneExt":24,"email":33},"Joseph C Watso, PhD","CONTACT","850-644-5260","jwatso@fsu.edu",[35],{"facility":5,"status":36,"city":37,"state":38,"zip":39,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"RECRUITING","Tallahassee","Florida","32306","United States","US",{"type":43,"coordinates":44},"Point",[45,46],-84.28073,30.43826,{"lat":46,"lon":45},[49],{"name":50,"role":31,"phone":24,"phoneExt":24,"email":24},"Joseph Watso",{"type":52,"investigatorFullName":50,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","Assistant Professor",[55],{"name":56,"class":57},"National Heart, Lung, and Blood Institute (NHLBI)","NIH","100474571","inspiratory-muscle-strength-training-in-adults-with-obesity-100474571",false,"NCT05459636","Inspiratory Muscle Strength Training in Adults With Obesity","Time-Efficient Inspiratory Muscle Strength Training as a New Approach to Lower Blood Pressure, Improve Respiratory Function, and Reduce Exertional Dyspnea in Adults With Obesity","Inclusion Criteria:\n\n\\- Body mass index 30 - 40 kg\u002Fm2\n\nExclusion Criteria:\n\n* Not weight stable (\\\u003C5% change in body mass over the past six months)\n* Overt cardiovascular, neurological, renal, liver, and\u002For metabolic illness (e.g., diabetes mellitus)\n* Current, or history of uncontrolled, Stage 2 hypertension (blood pressure \\>140 \u002F 90 mmHg; anti-hypertensive medications are permitted)\n* Diagnosed obstructive sleep apnea\n* Previous bariatric surgery\n* Diagnosis or signs (e.g., values below the lower limit of normal) of overt airway disease(s)\n* Current or recent (regular use within the past 6 months) use of tobacco or nicotine products (e.g., cigarettes, vaping)\n* Pregnant (self-reported and confirmed via urine pregnancy test), lactating (self-reported), or post-menopausal (self-reported) females\n* Prisoners\n* Per the POWERbreathe® company:\n\n  * Patients who have undergone recent abdominal surgery and those with abdominal hernia.\n  * Asthma patients who have a very low symptom perception and suffer from frequent, severe exacerbations or with an abnormally low perception of dyspnea.\n  * If a patient is suffering from a ruptured eardrum or any other condition of the ear.\n  * Patients with marked elevated left ventricular end-diastolic volume and pressure.\n  * Patients with worsening heart failure signs and symptoms after training.\n  * If an individual is suffering from a cold, sinusitis or respiratory tract infection, it is advised that they do not use the POWERbreathe device.",true,"ALL","18 Years","45 Years",{"count":70,"type":71},44,"ESTIMATED","INTERVENTIONAL",[74],"NA","The purpose of this study is to determine whether inspiratory muscle strength training reduces blood pressure in adults with obesity.",[77],"Obesity","2026-06-24",{"date":80,"type":81},"2026-06-26","ACTUAL",{"date":83,"type":81},"2023-12-07",{"date":85,"type":71},"2027-07-31",{"name":5,"class":6},1]