[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100594297":3},{"organization":4,"armGroups":7,"interventions":7,"overallOfficials":8,"centralContacts":12,"locations":19,"responsibleParty":38,"collaborators":7,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":43,"sex":48,"minAge":49,"maxAge":7,"enrollmentInfo":50,"targetDuration":7,"studyType":53,"phases":7,"briefSummary":54,"conditions":55,"keywords":7,"overallStatus":22,"whyStopped":7,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":68},{"fullName":5,"class":6},"University Health Network, Toronto","OTHER",null,[9],{"name":10,"affiliation":5,"role":11},"Ewan Goligher, MD","PRINCIPAL_INVESTIGATOR",[13],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},"Glauco Plens, MD","CONTACT","416-340-4800","7613","Glauco.Plens@uhn.ca",[20],{"facility":21,"status":22,"city":23,"state":24,"zip":25,"country":26,"countryCode":27,"cosmosGeoPoint":28,"geoPoint":33,"contacts":34},"Toronto General Hospital, University Health Network","RECRUITING","Toronto","Ontario","M5G2C4","Canada","CA",{"type":29,"coordinates":30},"Point",[31,32],-79.39864,43.70643,{"lat":32,"lon":31},[35],{"name":10,"role":15,"phone":16,"phoneExt":36,"email":37},"6810","ewan.goligher@uhn.ca",{"type":11,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Ewan Goligher","Ewan C Goligher, MD, PhD","100594297","inspiratory-work-of-breathing-before-and-after-extubation-100594297",false,"NCT07017608","Inspiratory Work of Breathing Before and After Extubation","INTEGRATION","Inclusion Criteria:\n\n* Adult patients intubated and ventilated\n\nExclusion Criteria:\n\n* Contraindication for esophageal catheter insertion: upper gastrointestinal surgery within prior 6 weeks, actively bleeding esophageal varices\n* Bronchopleural fistula\n* Contraindication for electrical impedance tomography: chest burns, skin lesions in the thorax, chest wall bandaging limiting electrode placement, unstable spinal lesions or fractures\n* Pregnancy","ALL","18 Years",{"count":51,"type":52},67,"ESTIMATED","OBSERVATIONAL","Critically ill patients who (1) are not able to maintain their airway, (2) cannot breathe on their own, or (3) both, are ones who often require tracheal intubation and support from a breathing machine (mechanical ventilator). When the patient is ready to be liberated from the mechanical ventilator because the initial insult for intubation has been resolved, the patient is screened using the readiness to wean test in preparation for extubation. As the patient passes this screening, a spontaneous breathing test (SBT) is initiated. Currently, there are many debates surrounding which SBT technique is most favorable. At Toronto General Hospital, the clinical team uses a zero-end expiratory pressure (ZEEP) trial. Once the patient successfully passes their SBT they are then extubated.\n\nThe patient will undergo a spontaneous breathing trial of continuous positive airway pressure (CPAP) of 5 cmH2O and ZEEP, in which time the investigators will be using a new technology called electrical impedance tomography (EIT), to study and compare the end expiratory lung volume (EELV); investigators will use an esophageal catheter to measure and monitor pressures in the lung, and also assess the patient's work of breathing. This will be repeated once the patient has been extubated safely.",[56,57,58],"Lung Transplant; Complications","Ventilator-Induced Lung Injury","Ventilator Associated Pneumonia","2025-06-03",{"date":61,"type":62},"2025-06-12","ACTUAL",{"date":64,"type":62},"2020-09-01",{"date":66,"type":52},"2026-12",{"name":5,"class":6},1]