[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100562029":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":57,"collaborators":21,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":62,"sex":67,"minAge":68,"maxAge":21,"enrollmentInfo":69,"targetDuration":21,"studyType":72,"phases":73,"briefSummary":75,"conditions":76,"keywords":80,"overallStatus":39,"whyStopped":21,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Azienda Ospedaliera Universitaria Integrata Verona","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Non-diabetic patients with ANOCA","EXPERIMENTAL","* Thermodilution based assessment of coronary microcirculation with the derivation of CFR and IMR\n* Hyperinsulinemic euglycemic clamp for insulin resistance assessment",[13,14],"Diagnostic Test: Thermodilution based assessment of coronary microcirculation","Diagnostic Test: Hyperinsulinemic-euglycemic Clamp test",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DIAGNOSTIC_TEST","Thermodilution based assessment of coronary microcirculation","Coronary microvascular assessment with the derivation of CFR, IMR and MRR will be performed using a standard pressure\u002Fthermodilution guidewire.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Hyperinsulinemic-euglycemic Clamp test","Infusion of insulin and glucose adjusting rate of glucose infusion to maintaine plasma glucose around 90 mg\u002FdL by monitoring plasma glucose levels every 5-10 minutes",[9],[27],{"name":28,"affiliation":29,"role":30},"Roberto Scarsini MD PhD","Azienda Ospedaliera Universitaria di Verona","PRINCIPAL_INVESTIGATOR",[32],{"name":33,"role":34,"phone":35,"phoneExt":21,"email":36},"Natascia Antonioli","CONTACT","0039 0458122320","studi.clinici.cardiologia@aovr.veneto.it",[38],{"facility":29,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"RECRUITING","Verona","VR","37126","Italy","IT",{"type":46,"coordinates":47},"Point",[48,49],10.9938,45.43854,{"lat":49,"lon":48},[52,55],{"name":53,"role":34,"phone":35,"phoneExt":21,"email":54},"Flavio Luciano Ribichini","flavio.ribichini@univr.it",{"name":56,"role":34,"phone":21,"phoneExt":21,"email":21},"Roberto Scarsini, MD PhD",{"type":30,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":21,"oldOrganization":21},"Roberto Scarsini","Principal Investigator","100562029","insulin-resistance-and-coronary-microvascular-dysfunction-in-patients-with-myocardial-ischemia-and-non-obstructive-coronary-artery-disease-100562029",false,"NCT06597851","Insulin Resistance and Coronary Microvascular Dysfunction in Patients with Myocardial Ischemia and Non-obstructive Coronary Artery Disease","IRIN","Inclusion Criteria:\n\n* Aged over 18 years.\n* Cardiac chest pain with evidence of myocardial ischemia at noninvasive myocardial stress imaging and clinical indication to diagnostic coronary angiography\n* Willing and able to give informed consent for participation in the study\n\nExclusion Criteria:\n\n* Obstructive CAD (defined as more than 70% luminal stenosis and\u002For FFR ≤0.80 in 1 or more epicardial vessels).\n* History of previous myocardial infarction, percutaneous revascularization or coronary-aortic bypass graft (CABG) surgery.\n* Diagnosis of type II diabetes.\n* BMI ≥ 35 kg\u002Fm2.\n* Stage IV and V of chronic kidney disease (eGFR ≤ 30 ml\u002Fmin, estimated through CKD - EPI Creatinine Equation).\n* Allergy or other contraindication to iodinated contrast and\u002For gadolinium and\u002For adenosine.\n* Chronic resting O2 saturation ≤ 85%.\n* Pregnancy or suspected pregnancy.","ALL","18 Years",{"count":70,"type":71},40,"ESTIMATED","INTERVENTIONAL",[74],"NA","The goal of this prospective study is to assess the correlation between coronary microvascular disfunction and insulin resistance in patients with INOCA.\n\nPatients with ANOCA and without diabetes will undergo invasive coronary microvascular assessment through coronary angiography and insulin resistance assessment through hyperinsulinemic-euglycemic clamp test.\n\nPatients enrolled in the study will be followed for a period of 2 years to monitor their clinical status.",[77,78,79],"Coronary Microvascular Dysfunction","Coronary Microvascular Disease","Insulin Resistance",[77,78,79,81,82,83,84],"INOCA","ANOCA","CMD","hyperinsulinemic-euglycemic clamp test","2024-09-12",{"date":87,"type":88},"2024-09-19","ACTUAL",{"date":90,"type":88},"2024-06-24",{"date":92,"type":71},"2026-06-30",{"name":5,"class":6},1]