[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100457110":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":59,"collaborators":12,"id":61,"slug":62,"hasResults":63,"nctId":64,"briefTitle":65,"officialTitle":66,"acronym":12,"eligibilityCriteria":67,"healthyVolunteers":63,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":12,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":81,"overallStatus":42,"whyStopped":12,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},{"fullName":5,"class":6},"University of Guadalajara","OTHER",[8,13],{"label":9,"type":10,"description":11,"interventionNames":12},"Control","NO_INTERVENTION","This group will receive non-surgical periodontal treatment, however they will not receive any modification to their diet",null,{"label":14,"type":15,"description":16,"interventionNames":17},"Intervention","EXPERIMENTAL","This group will receive non-surgical periodontal treatment, and also as a treatment of interest, will receive the indication to consume \\~ 350 mg of nitrate from vegetables, as well as an accompaniment to achieve this objective.",[18],"Dietary Supplement: Intake of nitrate rich vegetables",[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":12},"DIETARY_SUPPLEMENT","Intake of nitrate rich vegetables","Nutritional intervention for 10 weeks to increase the consumption of vegetables rich in nitrate. At the beginning of the NSPT on visit 1 (week 2), the first of 5 nutritional interventions will begin with the objective of consuming \\~ 350 mg of nitrate daily from vegetables",[14],[26],{"name":27,"affiliation":5,"role":28},"Lucrecia Carrera, PhD","PRINCIPAL_INVESTIGATOR",[30,35],{"name":27,"role":31,"phone":32,"phoneExt":33,"email":34},"CONTACT","+523310585200","34240","lucrecia.carrera@academicos.udg.mx",{"name":36,"role":31,"phone":37,"phoneExt":12,"email":38},"Nydia S Sanchez, Bachelor","+523311777088","nydia.sanchez0207@alumnos.udg.mx",[40],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Integral Dental Clinics CUCS UDG","RECRUITING","Guadalajara","Jalisco","44340","Mexico","MX",{"type":49,"coordinates":50},"Point",[51,52],-103.34749,20.67738,{"lat":52,"lon":51},[55],{"name":56,"role":31,"phone":57,"phoneExt":12,"email":58},"Alondra Ruiz, PhD","+523312467525","alondracrg80@gmail.com",{"type":60,"investigatorFullName":12,"investigatorTitle":12,"investigatorAffiliation":12,"oldNameTitle":12,"oldOrganization":12},"SPONSOR","100457110","intake-of-nitrate-rich-vegetables-and-their-effect-on-inflammatory-molecules-and-oral-microbiota-of-patients-with-periodontitis-100457110",false,"NCT05232331","Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients With Periodontitis","Effect of Nitrate-rich Vegetable Intake on Inflammatory Molecule Levels, Nitrate-reducing Capacity and Oral Microbiota Composition in Patients With Periodontitis","Inclusion Criteria:\n\n* Men and\u002For women from 30 to 65 years old\n* Voluntary participation and signing the written informed consent\n* Not receiving nutritional treatment at the time of uptake\n* Availability to attend all scheduled visits\n* Have an indication to receive nonsurgical periodontal treatment (NSPT)\n* Interdental clinical insertion loss ≥3mm and ≥5mm in the buccal or oral area of two or more non-adjacent teeth\n* Detectable depths ≥ 5mm in two or more teeth\n* Radiographic evidence of periodontal bone loss\n\nExclusion Criteria:\n\n* Trauma-Induced Gingival Recessions\n* Cervical caries\n* History of bleeding diathesis\n* Pregnant or nursing women\n* BMI \\\u003C18.5 kg \u002F m2\n* History of any of the following self-reported diseases: type 2 diabetes mellitus, high blood pressure, kidney or liver disease, inflammatory bowel diseases, autoimmune diseases and\u002F or use of medications to control these diseases.\n* Having or presenting a high risk of infection by tuberculosis, hepatitis B or Human Immunodeficiency Virus (HIV)\n* Use of antibiotics (including antibiotic oral rinse) 6 months prior to or during the study\n* Having received specialized periodontal treatment in the previous 6 months.\n* Smoking habit\n* Require an interpreter or not understand Spanish to attend or provide written material.","ALL","30 Years","65 Years",{"count":72,"type":73},60,"ESTIMATED","INTERVENTIONAL",[76],"NA","Vegetables, mainly green leafy ones and some others like beets, are a rich source of nitrate. Nitrate metabolism has shown benefits to the body and there are recent studies that agree that the consumption of nitrates from vegetables can modify the oral microbiota by increasing species with nitrate-reducing capacity, which are also bacteria that are associated with oral health.",[79,80],"Periodontal Diseases","Periodontitis",[82,83,84,80,85],"Nitrates","Vegetables","Oral Microbiota","Inflammatory molecules","2024-08-13",{"date":88,"type":89},"2024-08-16","ACTUAL",{"date":91,"type":89},"2021-06-23",{"date":93,"type":73},"2025-12-31",{"name":5,"class":6},1]