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d'Alacant",{"type":38,"coordinates":540},[541,542],-0.43623,38.40148,{"lat":542,"lon":541},[545],{"name":546,"role":27,"phone":18,"phoneExt":18,"email":18},"JOSE MORENO ARRIBAS, MD",{"facility":548,"status":33,"city":549,"state":18,"zip":18,"country":463,"countryCode":464,"cosmosGeoPoint":550,"geoPoint":554,"contacts":555},"Hospital Universitario de Tarragona Joan XXIII-Cardiology","Tarragona",{"type":38,"coordinates":551},[552,553],1.24544,41.11905,{"lat":553,"lon":552},[556],{"name":557,"role":27,"phone":18,"phoneExt":18,"email":18},"JOSÉ LUÍS FERREIRO-GUTIÉRREZ, MD",{"facility":559,"status":33,"city":560,"state":18,"zip":18,"country":463,"countryCode":464,"cosmosGeoPoint":561,"geoPoint":565,"contacts":566},"Pius Hospital de Valls-Cardiology","Valls",{"type":38,"coordinates":562},[563,564],1.24993,41.28612,{"lat":564,"lon":563},[567],{"name":568,"role":27,"phone":18,"phoneExt":18,"email":18},"LEYDIMAR ADEL ANMAD SHIHADEH MUSA, MD",{"type":570,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[572,574,576,578,580,582],{"name":573,"class":6},"Aalborg University",{"name":575,"class":6},"University of Belgrade",{"name":577,"class":6},"Universidad de Murcia",{"name":579,"class":6},"Carol Davila University of Medicine and Pharmacy",{"name":581,"class":6},"Plovdiv Medical University",{"name":583,"class":6},"University of Liverpool","100575649","integrated-approach-in-frail-older-people-with-atrial-fibrillation-100575649",false,"NCT06775028","Integrated Approach in Frail Older People with Atrial Fibrillation","AFFIRMO - Atrial Fibrillation Integrated Approach in Frail, Multimorbid and Polymedicated Older People","AFFIRMO","Inclusion Criteria:\n\n* Outpatients of both sexes with age ≥65 years;\n* First diagnosed, paroxysmal, persistent, long-standing persistent or permanent AF, confirmed as per guideline-recommended diagnostic criteria for AF, e.g. with electrocardiogram (ECG) or Holter monitoring;\n* ≥1 additional long-term comorbidity, thus fulfilling the definition of multimorbidity: hypertension (treated with at least 2 antihypertensive drugs), coronary artery disease (CAD), peripheral artery disease, heart failure, stroke\u002FTIA, diabetes mellitus, COPD, CKD.\n\nExclusion Criteria:\n\n* Mechanical prosthetic heart valve or moderate\u002Fsevere mitral stenosis;\n* Patient unwilling to be enrolled and sign written informed consent;\n* Patient unable to understand the study and attend the follow-up;\n* Serious diseases with a life expectancy inferior to 12 months;\n* Patients included in other interventional studies.\n\nOnly for sites randomized to the iABC group:\n\n\\- Patient without a device suitable for iABC use.","ALL","65 Years",{"count":595,"type":596},1250,"ESTIMATED","INTERVENTIONAL",[599],"NA","The study will verify if a structured multidisciplinary approach (called iABC), aimed to improve the appropriate management of elderly AF patients with multimorbidity (the i-ABC group), would provide a clear evidence of an improvement in clinical conditions and quality of life compared to usual clinical care. The i-ABC group in AFFIRMO will follow the ABC pathway, focused on three domains: avoid stroke with anticoagulation (with optimized VKA or label-adherent DOAC use); better symptom management; and optimized management of associated cardiovascular and non cardiovascular comorbidities.\n\nThe study will be conducted in Bulgaria, Denmark, Italy, Romania, Serbia and Spain .",[602,603,604,605,606,607,608,609,610,611],"Atrial Fibrillation (AF)","Hypertension","Coronary Arterial Disease (CAD)","Heart Failure","COPD","Peripheral Arterial Disease","CKD","Diabetes Mellitus","Stroke","TIA (Transient Ischemic Attack)",[613,614,615],"iABC","Atrial Fibrillation","Cluster Trial","2025-01-09",{"date":618,"type":619},"2025-01-14","ACTUAL",{"date":621,"type":619},"2024-04-11",{"date":623,"type":596},"2026-01-31",{"name":5,"class":6},50]