[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100413654":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":20,"centralContacts":25,"locations":30,"responsibleParty":46,"collaborators":48,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":7,"enrollmentInfo":64,"targetDuration":7,"studyType":67,"phases":7,"briefSummary":68,"conditions":69,"keywords":7,"overallStatus":32,"whyStopped":7,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},{"fullName":5,"class":6},"Manchester University NHS Foundation Trust","OTHER_GOV",null,[9,13,17],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"OTHER","Blood tests for Single Nucleotide Polymorphisms","This extra test would be performed on participants assessed in the specialist liver clinic. This test would require an extra 5ml of blood to be taken at the time of routine blood tests for clinical purposes.",{"type":14,"name":15,"description":16,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Faecal microbiome analysis","This test will be undertaken for all participants who give consent and are assessed through the new liver care pathway, in the community liver assessment clinic. All participants will be given the equipment to take a stool sample at the time of presentation at the community liver assessment clinic and asked to return the sample to the clinic. The sample will be processed to remove genetic material so the microbiome can be identified.",{"type":14,"name":18,"description":19,"armGroupLabels":7,"otherNames":7},"Serum for diagnostic biomarkers","Blood samples will be taken alongside blood taken for clinical assessment. In total, an extra 5ml of blood. These samples will be used to explore novel blood biomarkers using ELISA and mass-spectroscopy techniques in the University of Manchester.",[21],{"name":22,"affiliation":23,"role":24},"Varinder Athwal","Manchester University NHS Foundation Trust\u002FManchester University","PRINCIPAL_INVESTIGATOR",[26],{"name":22,"role":27,"phone":28,"phoneExt":7,"email":29},"CONTACT","0161 291 5354","Varinder.athwal@manchester.ac.uk",[31],{"facility":5,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"RECRUITING","Manchester","Greater Manchester","M13 9WL","United Kingdom","UK",{"type":39,"coordinates":40},"Point",[41,42],-2.23743,53.48095,{"lat":42,"lon":41},[45],{"name":22,"role":27,"phone":7,"phoneExt":7,"email":29},{"type":47,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[49,51,53],{"name":50,"class":10},"University of Manchester",{"name":52,"class":10},"University of Nottingham",{"name":54,"class":6},"Innovate UK","100413654","integrated-diagnostics-for-early-diagnosis-of-liver-disease-100413654",false,"NCT04666402","Integrated Diagnostics for Early Diagnosis of Liver Disease","ID LIVER","Inclusion Criteria:\n\n* All patients referred to Community Liver Assessment Clinic.\n* Male or female \\> 18 years of age.\n* Females will be non-pregnant and non-lactating.\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years.\n* Pregnancy\u002Fbreast-feeding. Women of childbearing potential (not \\>2 years post- menopausal and\u002For not surgically sterilised) must have a negative blood serum pregnancy test.\n* Isolated bilirubinaemia.\n* Known pre-existing liver disease.\n* Acutely unwell.\n* Suspected malignancy.","ALL","18 Years",{"count":65,"type":66},1200,"ESTIMATED","OBSERVATIONAL","This is an observational study that will explore the hypothesis that by combining data from patients with liver disease with novel blood biomarkers, single nucleotide polymorphism (SNP) analysis and faecal microbiome analysis. The Investigators will improve diagnosis of liver fibrosis compared to the current available diagnostic tools.",[70,71,72,73],"Non-Alcoholic Fatty Liver Disease","Non-alcoholic Steatohepatitis","Alcoholic Liver Disease","Liver Fibroses","2026-02-05",{"date":76,"type":77},"2026-02-09","ACTUAL",{"date":79,"type":77},"2020-10-21",{"date":81,"type":66},"2027-03-31",{"name":5,"class":6},1]