[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100409197":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":13,"centralContacts":17,"locations":27,"responsibleParty":44,"collaborators":47,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":7,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":7,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":7,"briefSummary":64,"conditions":65,"keywords":70,"overallStatus":29,"whyStopped":7,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Sunnybrook Health Sciences Centre","OTHER",null,[9],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Needle Core Biopsies","Not an interventional study",[14],{"name":15,"affiliation":5,"role":16},"Katarzyna J Jerzak, MD MSc FRCPC","PRINCIPAL_INVESTIGATOR",[18,23],{"name":15,"role":19,"phone":20,"phoneExt":21,"email":22},"CONTACT","416-480-6100","5248","katarzyna.jerzak@sunnybrook.ca",{"name":24,"role":19,"phone":20,"phoneExt":25,"email":26},"Hon S Leong","5748","hon.leong@sri.utoronto.ca",[28],{"facility":5,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"RECRUITING","Toronto","Ontario","M4N 3M5","Canada","CA",{"type":36,"coordinates":37},"Point",[38,39],-79.39864,43.70643,{"lat":39,"lon":38},[42,43],{"name":15,"role":19,"phone":20,"phoneExt":21,"email":22},{"name":24,"role":19,"phone":20,"phoneExt":25,"email":26},{"type":16,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":7,"oldOrganization":7},"Dr. Katarzyna Jerzak","Medical Oncologist & Associate Scientist",[48],{"name":49,"class":6},"AFP Innovation Fund","100409197","integrated-patient-avatars-for-guiding-systemic-therapy-treatments-in-metastatic-breast-cancer-patients-100409197",false,"NCT04608357","Integrated Patient Avatars for Guiding Systemic Therapy Treatments in Metastatic Breast Cancer Patients","Integrated Patient Avatars for Guiding Systemic Therapy Treatments: \"Intuition-Free\" Decisions in Metastatic Breast Cancer Patients","Inclusion Criteria:\n\n1. Age 18+.\n2. Metastatic breast cancer irrespective of subtype.\n3. Measurable disease as per RECIST 1.1 criteria.\n4. Metastatic disease involving the lymph nodes and\u002For visceral organs is required.\n5. Willingness to undergo a biopsy prior to the start of planned systemic therapy.\n\nExclusion Criteria:\n\n1. Lack of feasibility to obtain a core biopsy of a metastatic site other than the bone (e.g. a metastatic lesion cannot be safely sampled due to proximity to vasculature).\n2. Inability to provide informed consent.","ALL","18 Years",{"count":60,"type":61},25,"ESTIMATED","3 Years","OBSERVATIONAL","The investigators propose to use clinically validated patient avatar technology (\"PDXovo\") that can test multiple drugs against patients' cancers to identify the most promising systemic therapy for each individual.",[66,67,68,69],"Breast Cancer","Breast Neoplasms","Metastatic Breast Cancer","Cancer, Breast",[71,72,73,74,75,76],"metastatic breast cancer","systemic therapy","needle core biopsy","PDXovo","feasibility study","tumor take rate","2025-01-17",{"date":79,"type":80},"2025-01-20","ACTUAL",{"date":82,"type":80},"2021-07-21",{"date":84,"type":61},"2027-12",{"name":5,"class":6},1]