[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602560":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":33,"centralContacts":41,"locations":51,"responsibleParty":76,"collaborators":78,"id":86,"slug":87,"hasResults":88,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":88,"sex":93,"minAge":94,"maxAge":45,"enrollmentInfo":95,"targetDuration":45,"studyType":98,"phases":99,"briefSummary":101,"conditions":102,"keywords":104,"overallStatus":115,"whyStopped":45,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":125},{"fullName":5,"class":6},"Universite du Littoral Cote d'Opale","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Adapted Physical Activity Only","EXPERIMENTAL","Participants receive 10 individualized sessions of adapted physical activity (45-60 minutes each), designed according to neuromuscular rehabilitation guidelines. The sessions focus on strength, endurance, and movement awareness, and are tailored to the physical limitations and fatigue patterns typical of patients with Myasthenia Gravis . No artistic or expressive components are included",[13],"Behavioral: Adapted Physical Activity Only",{"label":15,"type":10,"description":16,"interventionNames":17},"Adapted Physical Activity + Art Therapy","Participants receive 10 individualized sessions of adapted physical activity (45-60 minutes each) incorporating expressive and artistic components inspired by movement-based art therapy (e.g., dramatization, role-play, symbolic movement). These integrated sessions aim to enhance physical engagement while also addressing emotional expression, body image, and psychosocial well-being. The approach is co-constructed with the participant based on a preliminary qualitative assessment.\n\nThis intervention combines adapted physical activity with movement-based art therapy techniques. The art therapy component is not administered separately but is fully integrated into the APA sessions, forming a unified intervention model. Exercises include expressive movement, dramatization, and body awareness activities delivered by APA specialists with complementary training in art-based methods.",[18],"Behavioral: Adapted Physical Activity + Art Therapy",[20,26],{"type":21,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"BEHAVIORAL","This intervention consists of 10 individual Adapted Physical Activity (APA) sessions over five weeks, each lasting 45 to 60 minutes. Sessions are delivered by a trained APA instructor and focus on muscle strengthening, endurance, and body awareness. Exercises are tailored to the functional capacities and fatigability of patients living with Myasthenia Gravis. The delivery format includes a mix of in-person and remote sessions, with individualized adaptation based on patient needs.",[9],[25],"Standard APA sessions",{"type":21,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"This intervention includes 10 individualized sessions of APA integrated with movement-based Art Therapy, delivered over five weeks (45-60 minutes each). The program incorporates creative and expressive methods (e.g., role play, improvisation, dramatized movement, dramatherapy) within a therapeutic physical activity framework. It is designed to support both physical functioning and psychosocial well-being. The artistic dimension is adapted to the patients' preferences and capacities, as identified during the baseline anamnesis interview.",[15],[30,31,32],"Artistic APA","Movement-based expressive APA","Dramatherapy",[34,38],{"name":35,"affiliation":36,"role":37},"Alessandro Porrovecchio, PhD","Université du Littoral Cote d'Opale","PRINCIPAL_INVESTIGATOR",{"name":39,"affiliation":40,"role":37},"Céline Tard, PhD Dr","University Hospital of Lille",[42,47],{"name":35,"role":43,"phone":44,"phoneExt":45,"email":46},"CONTACT","0033647120423",null,"alessandro.porrovecchio@univ-littoral.fr",{"name":48,"role":43,"phone":49,"phoneExt":45,"email":50},"Célia Leclercq","0033618946935","celialeclercq8@gmail.com",[52],{"facility":53,"status":45,"city":54,"state":55,"zip":56,"country":57,"countryCode":58,"cosmosGeoPoint":59,"geoPoint":64,"contacts":65},"Lille University Hospital","Lille","Hauts-de-France","59000","France","FR",{"type":60,"coordinates":61},"Point",[62,63],3.05512,50.63391,{"lat":63,"lon":62},[66,70,73,74],{"name":67,"role":43,"phone":68,"phoneExt":45,"email":69},"Céline Tard Dr, PhD","0033320445808","CELINE.TARD@chu-lille.fr",{"name":71,"role":72,"phone":45,"phoneExt":45,"email":45},"Célia Leclercq Célia Leclercq, PhD Student","SUB_INVESTIGATOR",{"name":35,"role":37,"phone":45,"phoneExt":45,"email":45},{"name":75,"role":72,"phone":45,"phoneExt":45,"email":45},"Annie Archer, Collaborator",{"type":77,"investigatorFullName":45,"investigatorTitle":45,"investigatorAffiliation":45,"oldNameTitle":45,"oldOrganization":45},"SPONSOR",[79,81,84],{"name":80,"class":6},"University Hospital, Lille",{"name":82,"class":83},"Fondation Maladies Rares (French Foundation for Rare Diseases)","UNKNOWN",{"name":85,"class":83},"AFM Téléthon","100602560","integrating-art-therapy-and-adapted-physical-activity-toward-improved-quality-of-life-in-patients-with-myasthenia-gravis-100602560",false,"NCT07125105","Integrating Art Therapy and Adapted Physical Activity: Toward Improved Quality of Life in Patients With Myasthenia Gravis","APART-MG","Inclusion Criteria:\n\n* Confirmed diagnosis of myasthenia gravis of any form established by a referring neurologist.\n* Patients followed at Lille University Hospital and its partners (Neuromuscular Diseases Reference Center, hospitals of the Côte d'Opale, home care services), or at Amiens University Hospital.\n* No major contraindications to participating in adapted physical activity and\u002For art therapy, as evaluated by the medical team.\n* Availability to attend all 10 sessions of the APA-only program and the combined APA + AT program, according to the cross-over design.\n* Signed informed consent after being informed about the objectives and requirements of the project.\n\nExclusion Criteria:\n\n* Severe comorbidities limiting participation in adapted physical activity or art therapy.\n* Advanced cognitive decline or severe neuropsychiatric disorders preventing understanding and participation.\n* Unstable medical treatment with recent changes that may affect fatigability or physical capacity \u002F poorly controlled myasthenia gravis.\n* Physical inability to participate in adapted physical activity or art therapy, even with adaptations.\n* Unavailability to complete the entire protocol (e.g., relocation, prolonged absence).\n* Refusal or inability to provide informed consent (e.g., patient under guardianship without legal authorization).\n* Difficulty accessing the intervention locations without possible alternatives such as remote or home-based sessions.","ALL","18 Years",{"count":96,"type":97},102,"ESTIMATED","INTERVENTIONAL",[100],"NA","Myasthenia Gravis (MG) is a rare neuromuscular disease characterized by fluctuating muscle weakness and excessive fatigability. Although medical treatments have improved, MG continues to significantly impact patients' physical, emotional, and social well-being. Current care primarily focuses on symptom management, often overlooking the broader psychosocial needs of patients.\n\nThis study explores an innovative and holistic approach combining Adapted Physical Activity (APA) and Art Therapy (AT) to improve quality of life in adults with MG. The intervention includes two 6-week phases in a crossover design: one with APA alone and one combining APA with personalized AT sessions focused on body awareness, movement, and creative expression.\n\nThe investigators hypothesize that the addition of AT to a standardized APA program will significantly enhance patients' engagement and well-being, resulting in improved quality of life, reduced fatigue, and better mental health outcomes.\n\nA total of 102 adult participants will be recruited from several hospitals in northern France (Lille, Dunkerque, Calais, Boulogne-sur-Mer, and Saint-Omer). Participants will be randomly assigned to begin with either APA alone or APA+AT. All interventions are tailored to the specific needs of MG patients and will be delivered both in person and online, depending on participant needs.\n\nOutcomes will be evaluated using standardized questionnaires (e.g., MG-QOL15, FSS, HADS), physical performance tests (e.g., handgrip strength, sit-to-stand), and accelerometry. Qualitative data will be collected through semi-structured interviews, ethnographic observations and art based research to better understand patients' experiences.\n\nThe study has received ethical approval from the French National Ethics Committee (CPP) and involves minimal risk. Participation is voluntary, with no financial compensation. This protocol may pave the way for broader application of APA+AT models in other rare or chronic conditions that involve fluctuating fatigue and psychosocial complexity.",[103],"Myasthenia Gravis",[103,105,106,107,108,109,110,111,112,113,114,32],"Art Therapy","Adapted Physical Activity","Randomized","Rare Neuromuscular Diseases","Crossover Trial","Quality of Life","Psychosocial Intervention","Fatigue in Chronic Illness","Mental Health in Rare Diseases","Non-pharmacological Interventions","NOT_YET_RECRUITING","2025-08-07",{"date":118,"type":119},"2025-08-15","ACTUAL",{"date":121,"type":97},"2025-11-01",{"date":123,"type":97},"2028-10-30",{"name":5,"class":6},1]