[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100587738":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":45,"centralContacts":50,"locations":59,"responsibleParty":78,"collaborators":35,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":84,"acronym":35,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":87,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":35,"studyType":93,"phases":94,"briefSummary":96,"conditions":97,"keywords":99,"overallStatus":103,"whyStopped":35,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"VA Greater Los Angeles Healthcare System","FED",[8,16,20,24],{"label":9,"type":10,"description":11,"interventionNames":12},"Diet 1 (one of the three kinds of diets)","ACTIVE_COMPARATOR","participants will be randomized to diet 1 for 2 weeks. A continuous glucose monitor (CGM) will be placed and the integrated sweat sensor and vascular sensor will be administered.",[13,14,15],"Dietary Supplement: Mediterranean diet (MED), high-fat\u002Flow carb diet (HF\u002FLC), and low-fat diet (LF)","Device: The integrated sweat sensor and vascular sensor (wearable)","Device: continuous glucose monitor (CGM)",{"label":17,"type":10,"description":18,"interventionNames":19},"Diet 2 (one of the two remaining kinds of diets, excluding Diet 1)","participants will be randomized to diet 2 for 2 weeks. A continuous glucose monitor (CGM) will be placed and the integrated sweat sensor and vascular sensor will be administered.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"Diet 3 (the final remaining diet)","participants will be randomized to diet 3 for 2 weeks. A continuous glucose monitor (CGM) will be placed and the integrated sweat sensor and vascular sensor will be administered.",[13,14,15],{"label":25,"type":26,"description":27,"interventionNames":28},"Habitual diet as a baseline","EXPERIMENTAL","All participants will consume their habitual diet for 2 weeks to establish baseline. A continuous glucose monitor (CGM) will be placed and the integrated sweat sensor and vascular sensor will be administered.",[14,15],[30,36,41],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"DIETARY_SUPPLEMENT","Mediterranean diet (MED), high-fat\u002Flow carb diet (HF\u002FLC), and low-fat diet (LF)","Participants will be randomized to either Mediterranean diet (MED), high-fat\u002Flow carb diet (HF\u002FLC), or low-fat diet (LF).",[9,17,21],null,{"type":37,"name":38,"description":39,"armGroupLabels":40,"otherNames":35},"DEVICE","The integrated sweat sensor and vascular sensor (wearable)","The integrated sweat sensor and vascular sensor will be worn of each diet period.",[9,17,21,25],{"type":37,"name":42,"description":43,"armGroupLabels":44,"otherNames":35},"continuous glucose monitor (CGM)","A continuous glucose monitor (CGM) will be placed on the patients during each diet period.",[9,17,21,25],[46],{"name":47,"affiliation":48,"role":49},"Tzung Hsiai, M.D., Ph.D.","VAGLAHS and UCLA","PRINCIPAL_INVESTIGATOR",[51,55],{"name":47,"role":52,"phone":53,"phoneExt":35,"email":54},"CONTACT","310-478-3711","thsiai@mednet.ucla.edu",{"name":56,"role":52,"phone":57,"phoneExt":35,"email":58},"Peng Zhao, M.D., Ph.D.","310-279-0248","pengzhao@mednet.ucla.edu",[60],{"facility":61,"status":35,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Va Greater Los Angeles Healthcare System","Los Angeles","California","90073","United States","US",{"type":68,"coordinates":69},"Point",[70,71],-118.24368,34.05223,{"lat":71,"lon":70},[74,76],{"name":47,"role":52,"phone":75,"phoneExt":35,"email":54},"310-825-9029",{"name":77,"role":52,"phone":57,"phoneExt":35,"email":58},"Peng Zhao",{"type":79,"investigatorFullName":35,"investigatorTitle":35,"investigatorAffiliation":35,"oldNameTitle":35,"oldOrganization":35},"SPONSOR","100587738","integrating-metabolic-and-vascular-sensors-to-monitor-cardiometabolic-disorders-after-nutrition-interventions-100587738",false,"NCT06932289","Integrating Metabolic and Vascular Sensors to Monitor Cardiometabolic Disorders After Nutrition Interventions","Inclusion Criteria:\n\n* United States Veterans\n* Male or female, age 18-55 years at the time of signing informed consent.\n* at least 2 of the following: waist circumference \\> 40\" for men and 35\" for women, FBS \\>100 mg\u002Fdl, triglycerides \\> 150 but \\\u003C 500 mg\u002FdL, HDL \\\u003C 40 mg\u002FdL, Pre- hypertension or hypertension (BP\\>120\u002F80 mmHg but \\\u003C150\u002F90 mmHg)\n\nExclusion Criteria:\n\n* History of diabetes require medications\n* History of alcohol intake ≥ 20g\u002Fday\n* History of cirrhosis\n* Renal impairment measured as estimated Glomerular Filtration Rate (eGFR) value of \\\u003C30 mL\u002Fmin\u002F1.73 m2\n* History of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months. History of thyroid disease and on a stable dose of prescription medication for 6 months or longer is acceptable.\n* Any unstable medical conditions or terminal diagnosis.\n* Any participant who is unwilling to sign an informed consent form will not be admitted into the study.",true,"ALL","18 Years","55 Years",{"count":91,"type":92},54,"ESTIMATED","INTERVENTIONAL",[95],"NA","It is a 12-week study. The participants will follow three different diets, and during each diet period, and the participants will wear our device, and blood samples will be collected.",[98],"NAFLD (Nonalcoholic Fatty Liver Disease)",[100,101,102],"NAFLD","metabolic responses","mixed meal challenge","NOT_YET_RECRUITING","2025-04-09",{"date":106,"type":107},"2025-04-17","ACTUAL",{"date":109,"type":92},"2025-05-01",{"date":111,"type":92},"2029-05-01",{"name":5,"class":6},1]