[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608787":3},{"organization":4,"armGroups":7,"interventions":8,"overallOfficials":7,"centralContacts":17,"locations":23,"responsibleParty":120,"collaborators":122,"id":130,"slug":131,"hasResults":132,"nctId":133,"briefTitle":134,"officialTitle":135,"acronym":136,"eligibilityCriteria":137,"healthyVolunteers":132,"sex":138,"minAge":7,"maxAge":7,"enrollmentInfo":139,"targetDuration":7,"studyType":142,"phases":7,"briefSummary":143,"conditions":144,"keywords":154,"overallStatus":26,"whyStopped":7,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":169},{"fullName":5,"class":6},"Hospital Universitari Vall d'Hebron Research Institute","OTHER",null,[9,13],{"type":10,"name":11,"description":12,"armGroupLabels":7,"otherNames":7},"GENETIC","Analysis of genetic modifiers","Genetic modifiers for rare anemia disorders will be analyzed through massive sequencing.",{"type":14,"name":15,"description":16,"armGroupLabels":7,"otherNames":7},"DIAGNOSTIC_TEST","Disease phenotyping","Peripheral blood samples will be used for conventional phenotyping characterization including among others: RBCs morphology, fragility osmotic test, hemoglobin fraction and quantification, hemoglobin stability test, EMA binding test, RBC enzymes quantification assay, RBC rheological properties through Lorrca Maxsis Osmoscan\u002FOxygescan (Lorrca®)",[18],{"name":19,"role":20,"phone":21,"phoneExt":7,"email":22},"Mar Mañú Pereira PhD","CONTACT","+34 93 489 4063","mar.manu@vhir.org",[24,42,50,61,72,81,92,103,111],{"facility":25,"status":26,"city":27,"state":27,"zip":28,"country":29,"countryCode":30,"cosmosGeoPoint":31,"geoPoint":36,"contacts":37},"Hospital de la Santa Creu i Sant Pau","RECRUITING","Barcelona","08025","Spain","ES",{"type":32,"coordinates":33},"Point",[34,35],2.15899,41.38879,{"lat":35,"lon":34},[38],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},"Anna collado gimbert","680810602","annacolladogimbert@gmail.com",{"facility":43,"status":26,"city":27,"state":27,"zip":44,"country":29,"countryCode":30,"cosmosGeoPoint":45,"geoPoint":47,"contacts":48},"Hospital Universitari Vall d'Hebron","08035",{"type":32,"coordinates":46},[34,35],{"lat":35,"lon":34},[49],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},{"facility":51,"status":26,"city":52,"state":27,"zip":53,"country":29,"countryCode":30,"cosmosGeoPoint":54,"geoPoint":58,"contacts":59},"Hospital Sant Joan de Déu","Esplugues de Llobregat","08950",{"type":32,"coordinates":55},[56,57],2.08809,41.37732,{"lat":57,"lon":56},[60],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},{"facility":62,"status":26,"city":63,"state":27,"zip":64,"country":29,"countryCode":30,"cosmosGeoPoint":65,"geoPoint":69,"contacts":70},"Hospital General de Granollers","Granollers","08402",{"type":32,"coordinates":66},[67,68],2.28773,41.60797,{"lat":68,"lon":67},[71],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},{"facility":73,"status":26,"city":74,"state":27,"zip":75,"country":29,"countryCode":30,"cosmosGeoPoint":76,"geoPoint":80,"contacts":7},"Consorci Sanitari del Maresme - Hospital de Mataró","Mataró","08304",{"type":32,"coordinates":77},[78,79],2.4445,41.54211,{"lat":79,"lon":78},{"facility":82,"status":26,"city":83,"state":27,"zip":84,"country":29,"countryCode":30,"cosmosGeoPoint":85,"geoPoint":89,"contacts":90},"Parc Taulí Hospital Universitari","Sabadell","08208",{"type":32,"coordinates":86},[87,88],2.10942,41.54329,{"lat":88,"lon":87},[91],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},{"facility":93,"status":26,"city":94,"state":27,"zip":95,"country":29,"countryCode":30,"cosmosGeoPoint":96,"geoPoint":100,"contacts":101},"Hospital Universitari Mútua de Terrassa","Terrassa","08221",{"type":32,"coordinates":97},[98,99],2.01667,41.56667,{"lat":99,"lon":98},[102],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},{"facility":104,"status":26,"city":94,"state":27,"zip":105,"country":29,"countryCode":30,"cosmosGeoPoint":106,"geoPoint":108,"contacts":109},"Consorci Sanitari de Terrassa","08227",{"type":32,"coordinates":107},[98,99],{"lat":99,"lon":98},[110],{"name":39,"role":20,"phone":40,"phoneExt":7,"email":41},{"facility":112,"status":26,"city":113,"state":113,"zip":114,"country":29,"countryCode":30,"cosmosGeoPoint":115,"geoPoint":119,"contacts":7},"Hospital Universitari Arnau de Vilanova","Lleida","25198",{"type":32,"coordinates":116},[117,118],0.62218,41.61674,{"lat":118,"lon":117},{"type":121,"investigatorFullName":7,"investigatorTitle":7,"investigatorAffiliation":7,"oldNameTitle":7,"oldOrganization":7},"SPONSOR",[123,125,127],{"name":124,"class":6},"Hospital Clinic of Barcelona",{"name":126,"class":6},"Institute for Bioengineering of Catalonia",{"name":128,"class":129},"Hospital Arnau de Vilanova, Lleida (Spain)","UNKNOWN","100608787","integrative-diagnosis-for-scd-and-other-rads-100608787",false,"NCT07206095","Integrative Diagnosis for SCD and Other RADs","Integrative Diagnosis of Sickle Cell Disease (SCD) and Other Rare Anemia Disorders (RADs) for Personalized Medicine","INTEGRA","Inclusion Criteria:\n\n* Patients sustaining a confirmed or suspected diagnosis of an hereditary rare hemolytic anemia:\n* Sickle cell disease\n* Thalassemic syndromes\n* Congenital dyserythropoietic anemia\n* Enzymopathy\n* Unstable Hemoblogin \u002F Altered oxygen affinity\n* Hereditary stomatocytosis\n* Hereditary pyropoikilocytosis\n* Hereditary spherocytosis with severe anemia (\\\u003C8 g\u002FdL) or inconclusive diagnosis:\n* Patient with chronic hemolytic anemia and red cell smear compatible, but with:\n* EMA binding test: inconclusive or negative\n* Genetic testing: no definitive diagnosis (VUS or no findings)\n* Not transplanted or undergoing gene therapy at the time of inclusion. Patients with graft failure without a new transplant may be included.\n\nExclusion Criteria:\n\n* Carrier traits in autosomal recessive hereditary anemias","ALL",{"count":140,"type":141},200,"ESTIMATED","OBSERVATIONAL","INTEGRA aims at enabling personalized medicine for RHADs patients by the establishment of an integrative diagnostic approach based on deep phenotypic and genetic characterization through combining new generation methodologies.",[145,146,147,148,149,150,151,152,153],"Sickle Cell Disease","Thalassaemia","Congenital Dyserythropoietic Anemia (CDA)","Enzyme Disorder; Anemia","Spherocytosis, Hereditary","Stomatocytosis","Hemoglobin Disorder","Anemia Due to Membrane Defect","Rare Anemia Disorders",[155,156,157,158,159],"SICKLE CELL DISEASE","RARE ANEMIA DISORDERS","PERSONALIZED MEDICINE","DIAGNOSIS","EKTACYTOMETRY","2025-09-25",{"date":162,"type":163},"2025-10-03","ACTUAL",{"date":165,"type":163},"2020-11-13",{"date":167,"type":141},"2028-05",{"name":5,"class":6},9]