[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100486054":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":35,"locations":42,"responsibleParty":177,"collaborators":25,"id":179,"slug":180,"hasResults":181,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":181,"sex":186,"minAge":187,"maxAge":25,"enrollmentInfo":188,"targetDuration":25,"studyType":191,"phases":192,"briefSummary":194,"conditions":195,"keywords":25,"overallStatus":45,"whyStopped":25,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":203,"completionDateStruct":205,"leadSponsor":207,"locationsCount":208},{"fullName":5,"class":6},"Assistance Publique Hopitaux De Marseille","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Control","Patients will have speech therapy assessment in addition to standard care.",[12],"Procedure: Speech therapy assessment",{"label":14,"type":15,"description":16,"interventionNames":17},"Experimental","EXPERIMENTAL","Patients will have speech therapy assessment and intensive speech rehabilitation",[18,12],"Procedure: Speech therapy",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Speech therapy","Patients will connect on an interface to pratice speech therapy",[14],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Speech therapy assessment","Patients will be followed by an speech therapist",[9,14],[31],{"name":32,"affiliation":33,"role":34},"Francois CREMIEUX","AP-HM","STUDY_DIRECTOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":40,"email":41},"Veronique Sabadell","CONTACT","0491385298","33","veronique.sabadell@ap-hm.fr",[43,58,69,80,92,106,117,128,136,144,155,166],{"facility":44,"status":45,"city":46,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Service EFSN - 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Hospices Civils Lyon","NOT_YET_RECRUITING","Lyon",{"type":50,"coordinates":85},[86,87],4.84789,45.74906,{"lat":87,"lon":86},[90],{"name":91,"role":38,"phone":25,"phoneExt":25,"email":25},"Alexandra Montavont",{"facility":93,"status":45,"city":94,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":95,"geoPoint":99,"contacts":100},"Service Epilptologie et Rythmologie Cérébrale","Marseille",{"type":50,"coordinates":96},[97,98],5.38107,43.29695,{"lat":98,"lon":97},[101,103],{"name":102,"role":38,"phone":25,"phoneExt":25,"email":41},"Véronique Sabadell",{"name":104,"role":38,"phone":25,"phoneExt":25,"email":105},"Agnes Trebuchon","agnes.trebuchon@ap-hm.fr",{"facility":107,"status":82,"city":108,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":109,"geoPoint":113,"contacts":114},"Service de Neurologie - Hôpital central -CHU Nancy","Nancy",{"type":50,"coordinates":110},[111,112],6.18496,48.68439,{"lat":112,"lon":111},[115],{"name":116,"role":38,"phone":25,"phoneExt":25,"email":25},"Louis Maillard",{"facility":118,"status":82,"city":119,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":120,"geoPoint":124,"contacts":125},"Département de Neurologie - 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CHU de Rennes","Rennes",{"type":50,"coordinates":148},[149,150],-1.67431,48.11109,{"lat":150,"lon":149},[153],{"name":154,"role":38,"phone":25,"phoneExt":25,"email":25},"Mihai Dragos-Millia",{"facility":156,"status":45,"city":157,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":158,"geoPoint":162,"contacts":163},"Service de Neurologie - Hôpitaux Universitaires, Hôpital de Hautepierre","Strasbourg",{"type":50,"coordinates":159},[160,161],7.74553,48.58392,{"lat":161,"lon":160},[164],{"name":165,"role":38,"phone":25,"phoneExt":25,"email":25},"Edouard Hirsch",{"facility":167,"status":82,"city":168,"state":25,"zip":25,"country":47,"countryCode":48,"cosmosGeoPoint":169,"geoPoint":173,"contacts":174},"Explorations Neurophysiologiques, Pôle des Neurosciences - Hôpital Pierre Paul Riquet, Purpan","Toulouse",{"type":50,"coordinates":170},[171,172],1.44367,43.60426,{"lat":172,"lon":171},[175],{"name":176,"role":38,"phone":25,"phoneExt":25,"email":25},"Marie Denuelle",{"type":178,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100486054","intensive-preoperative-speech-rehabilitation-in-drug-resistant-temporal-epilepsy-100486054",false,"NCT05609084","Intensive Preoperative Speech Rehabilitation in Drug-Resistant Temporal Epilepsy","REPREO","Inclusion Criteria:\n\n1. Patient 16 years of age and older,\n2. Patient whose epileptogenic area involves the temporal structures of the hemisphere specialized for language,\n3. Patient whose hemispheric specialization for language is known\n4. Patient willing to undergo resective surgery such as anterior temporal lobectomy or resection in the temporal lobe involving the hippocampus and\u002For the baso-temporal language area and whose planned surgery date is compatible with the performance of the study,\n5. Patient with a known NTB score\n6. Patient who has signed an informed consent or patient whose parents or legal guardians have signed the informed consent (or a single parent or legal guardian if applicable)\n7. Patient whose first language is French (1st language learned by the patient),\n8. Patient declaring to be familiar with the use of a computer and having access to an internet connection from home\n9. Patient affiliated or benefiting from a social security system.\n\nExclusion Criteria:\n\n1. Patient with a speech disorder that may impair intelligibility and compromise the use of the interface;\n2. Patient with an uncorrected hearing impairment,\n3. Patients with a total intelligence quotient (IQ) \\\u003C70 (assessed in the context of care, in the year preceding the surgical procedure)\n4. Patients who are pregnant, nursing, deprived of liberty, under guardianship or curatorship.","ALL","16 Years",{"count":189,"type":190},214,"ESTIMATED","INTERVENTIONAL",[193],"NA","Out of 30,000 new cases per year in France, 30% of epileptic patients are drug-resistant. Neurosurgery, which consists in resecting the epileptogenic zone, is the only chance of cure. In the case of temporal epilepsy of the language-dominant hemisphere (TLE), this procedure presents a high risk of increasing cognitive difficulties and may even be contraindicated for this reason alone. The difficulties found are impairments in lexical access (anomia) and verbal memory and affect more than 60% of patients . Preoperative cognitive rehabilitation could influence brain plasticity mechanisms but there are currently no recommendations on this topic. In this context, the investigators have developed a speech rehabilitation procedure specific to the needs of ELTPR patients. They rely on cognitive hypotheses explaining the disorders but also on models of rehabilitation-induced neural plasticity likely to improve cognitive reserve before surgery. The investigators hypothesize that preoperative cognitive language rehabilitation in ELTPR patients may decrease surgical risk and improve postoperative language prognosis.\n\nThe primary objective is to demonstrate the protective efficacy of preoperative speech rehabilitation on language performance postoperatively.",[196,197,198],"Epilepsy","Anomia","Temporal Lobe Epilepsy","2024-07-17",{"date":201,"type":202},"2024-07-18","ACTUAL",{"date":204,"type":202},"2023-03-30",{"date":206,"type":190},"2027-11-30",{"name":5,"class":6},12]