[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100601254":3},{"organization":4,"armGroups":7,"interventions":29,"overallOfficials":48,"centralContacts":53,"locations":58,"responsibleParty":74,"collaborators":35,"id":77,"slug":78,"hasResults":79,"nctId":80,"briefTitle":81,"officialTitle":81,"acronym":35,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":84,"minAge":85,"maxAge":86,"enrollmentInfo":87,"targetDuration":35,"studyType":90,"phases":91,"briefSummary":93,"conditions":94,"keywords":35,"overallStatus":99,"whyStopped":35,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Trustees of Dartmouth College","OTHER",[8,16,20,25],{"label":9,"type":10,"description":11,"interventionNames":12},"mindfulness (session 1)+ real tdcs, sham tdcs (session 2)","EXPERIMENTAL","Assigned to the mindfulness group in session 1. Will experience real tdcs, followed by sham tdcs for session 2.",[13,14,15],"Behavioral: tDCS stimulation (sham)","Behavioral: tDCS stimulation (real)","Behavioral: Mindful state induction",{"label":17,"type":10,"description":18,"interventionNames":19},"mindfulness (session 1) + sham tcds, real tdcs (session 2)","Assigned to the mindfulness group in session 1. Will experience sham tdcs, followed by real tdcs for session 2.",[13,14,15],{"label":21,"type":10,"description":22,"interventionNames":23},"no mindfulness (session 1) + real tdcs, sham tcds (session 2)","Assigned to the no-mindfulness control group in session 1. Will experience real tdcs, followed by sham tdcs for session 2.",[13,14,24],"Behavioral: No minfulness induction",{"label":26,"type":10,"description":27,"interventionNames":28},"no mindfulness (session 1) + sham tdcs, real tdcs (session 2)","Assigned to the no-mindfulness control group in session 1. Will experience sham tdcs, followed by real tdcs for session 2.",[13,14,24],[30,36,40,44],{"type":31,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"BEHAVIORAL","tDCS stimulation (sham)","Participants will receive sham tDCS stimulation in a 20 minute long task.\n\nTargets will be fitted with the tDCS stimulation electrode cap and instructed that they will receive 20 minutes of tDCS stimulation for the task. Sham tDCS will target the motor cortex at 2mA for 15 sec at the beginning of the session, and then the stimulator will turn off. The participant will then sit for the remaining time of the session with the electrode cap on their heads but turned off and not delivering stimulation.\n\nAll participants will receive sham tDCS stimulation (n=120).",[17,9,21,26],null,{"type":31,"name":37,"description":38,"armGroupLabels":39,"otherNames":35},"tDCS stimulation (real)","In their second session, participants will receive real tDCS stimulation in a 20 minute long task.\n\nTargets will be fitted with the tDCS stimulation electrode cap and instructed that they will receive 20 minutes of tDCS stimulation for the task. Real tDCS stimulation will target the motor cortex at 2mA for 20 minutes (full duration of task).\n\nAll participants will receive real tDCS stimulation (n=120).",[17,9,21,26],{"type":31,"name":41,"description":42,"armGroupLabels":43,"otherNames":35},"Mindful state induction","Experimenters trained in high-competence and high-warmth will train Group 1 participants on mindful state induction (n=60). Participants will undergo two stages for this training: 1) pain education to increase beliefs in endogenous brain regulatory capacities; and 2) the Stanford Hypnotic Induction Profile (HIP) test of hypnotizability and hypnotic induction of a relaxed state receptive to suggestion.\n\nIn Stage 1, participants will receive education that pain and affect are processes designed to protect the body from danger, which are transmitted rapidly and automatically to the brain. In Stage 2, participants are (a) seated in an upright, alert posture; and (b) receive suggestions that the ability to attend to and discriminate affective perceptions is achievable and that suppressing attention to the body and focusing on the task will allow them to perform optimally under pressure. Mindful state induction will only be explicitly instructed during session 1 for Group 1 participants.",[17,9],{"type":31,"name":45,"description":46,"armGroupLabels":47,"otherNames":35},"No minfulness induction","Participants in the No-mindfulness group will go through comparable stages but with different instructions. In the first stage, they will receive education about pain and affect as protective processes of the body. In the second stage, they will be seated in an upright, alert posture and receive suggestions to focus on the task and suppress attention to the body.",[21,26],[49],{"name":50,"affiliation":51,"role":52},"Tor Wager, Ph.D.","Dartmouth College","PRINCIPAL_INVESTIGATOR",[54],{"name":50,"role":55,"phone":56,"phoneExt":35,"email":57},"CONTACT","6036462196","tor.d.wager@dartmouth.edu",[59],{"facility":51,"status":35,"city":60,"state":61,"zip":62,"country":63,"countryCode":64,"cosmosGeoPoint":65,"geoPoint":70,"contacts":71},"Hanover","New Hampshire","03755","United States","US",{"type":66,"coordinates":67},"Point",[68,69],-72.28954,43.70229,{"lat":69,"lon":68},[72],{"name":50,"role":55,"phone":73,"phoneExt":35,"email":57},"603-646-2196",{"type":52,"investigatorFullName":75,"investigatorTitle":76,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"Tor Wager","Diana L. Taylor Distinguished Professor","100601254","interactions-between-placebo-effects-and-mindful-awareness-state-100601254",false,"NCT07108101","Interactions Between Placebo Effects and Mindful Awareness State","* No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis\n* No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis that can cause cognitive impairment\n* No self-reported current chronic pain, or acute pain within three months of the study period\n* No current migraine disorder (i.e., 15 headache days or more in 1 month)\n* No use of central nervous system-effective medication or other medication for neurological\u002Fpsychiatric treatment\n* No self-reported substance abuse within the last six months\n* No contraindication to MRI or tDCS (e.g., pregnancy, claustrophobia, pacemakers, ear\u002Fcochlear implants, shrapnel injuries, clips, or other ferromagnetic\u002Felectrical objects\u002Fdevices, diagnosed brain abnormality such as tumor, or skin lesions on the scalp.)\n* No contraindications for induced pain (e.g., no heart disease, high blood pressure, heart surgery, heart problems of any kind, severe asthma, respiratory problems of any kind, fibromyalgia, Raynaud's Syndrome or Disease, chronic pain, diabetes)\n* Participants must be capable of performing experimental tasks (e.g., are able to read), are fluent or native speakers of English\n* Participants must be able to tolerate the maximum level of thermal pain stimuli (for thermal stimuli)",true,"ALL","18 Years","55 Years",{"count":88,"type":89},120,"ESTIMATED","INTERVENTIONAL",[92],"NA","In this experiment,the investigators study the effects of interpersonally induced placebo effects and a mindful awareness induction on negative affect. Specifically, it will be examining the effects of interpersonally induced placebo effects (sham tDCS vs. control) and a mindful awareness induction (mindful state vs. control), as well as their interaction. Each group will undergo fMRI scanning and physiological recording will performing the Multimodal Negative Affect Task (MNAT).",[95,96,97,98],"Placebo Effect","Mindfulness","Pain","Transcranial Direct Current Stimulation (tDCS)","NOT_YET_RECRUITING","2025-07-31",{"date":102,"type":103},"2025-08-06","ACTUAL",{"date":105,"type":89},"2026-06-01",{"date":107,"type":89},"2028-11-30",{"name":5,"class":6},1]