[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100495524":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":40,"responsibleParty":59,"collaborators":24,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":67,"acronym":68,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":24,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":24,"overallStatus":43,"whyStopped":24,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"University of Regensburg","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"active treatment","EXPERIMENTAL","600 pulses of iTBS per day with 120% resting motor threshold applied five days in one week; tapering interval over 8 months (three treatments with breaks of three weeks; two treatments with breaks of five weeks; one last treatment after eight weeks)",[13],"Device: intermittend theta burst stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"active treatment 2","ACTIVE_COMPARATOR","600 pulses of iTBS per day with 120% resting motor threshold applied five sessions in one day (three treatments with breaks of three weeks; two treatments with breaks of five weeks; one last treatment after eight weeks)",[13],[20],{"type":21,"name":22,"description":22,"armGroupLabels":23,"otherNames":24},"DEVICE","intermittend theta burst stimulation",[9,15],null,[26],{"name":27,"affiliation":28,"role":29},"Berthold Langguth, Prof.","University Hospital of Regensburg, Department of Psychiatry and Psychotherapy at the Bezirksklinikum","PRINCIPAL_INVESTIGATOR",[31,36],{"name":32,"role":33,"phone":34,"phoneExt":24,"email":35},"Martin Schecklmann, Prof.","CONTACT","+49-941-941-2054","martin.schecklmann@medbo.de",{"name":37,"role":33,"phone":38,"phoneExt":24,"email":39},"Mohamed Abdelnaim, Dr.","+49-941-941-1256","mohamed.abdelnaim@medbo.de",[41],{"facility":42,"status":43,"city":44,"state":24,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Department of Psychiatry and Psychotherapy, University of Regensburg","RECRUITING","Regensburg","93055","Germany","DE",{"type":49,"coordinates":50},"Point",[51,52],12.10161,49.01513,{"lat":52,"lon":51},[55],{"name":56,"role":33,"phone":57,"phoneExt":24,"email":58},"Berthold Langguth","+49-941-941-2099","berthold.langguth@medbo.de",{"type":60,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"SPONSOR_INVESTIGATOR","Berthold Langguth, MD, Ph.D.","Prof. Dr.","100495524","intermittent-theta-burst-stimulation-for-maintenance-therapy-in-depression-100495524",false,"NCT05732311","Intermittent Theta Burst Stimulation for Maintenance Therapy in Depression","PROTECT","Inclusion Criteria:\n\n* adult women and men aged 18 to 70 years with an ICD-10 diagnosis of a depressive episode of depressive disorder (F32), recurrent depressive disorder (F33), or bipolar disorder (F31)\n* moderate or severe current episode prior to initial open iTBS treatment (HAMD-21 \\>16 points)\n* response to iTBS treatment (either reduction in HAMD score by 50% or score at the end of treatment \\\u003C11 points)\n* no concomitant psychotic symptoms.\n* no other relevant psychiatric disorder as assessed by the study physician\n* residence in Germany and German speaking that allows understanding of the information provided\n* patient is capable of giving consent\n\nExclusion Criteria:\n\n* fulfillment of the general contraindications for TMS (electrical implants or metallic objects in the body such as pacemakers or insulin pumps).\n* severe neurological diseases (e.g., cerebrovascular events, neurodegenerative diseases, epilepsy, malformations of the brain, severe head injury in the history)\n* current harmful use or dependence on alcohol, amphetamines, cocaine, benzodiazepines, anticonvulsants, or opiates\n* acute suicidality\n* pregnancy\n* current participation in another study","ALL","18 Years","70 Years",{"count":74,"type":75},60,"ESTIMATED","INTERVENTIONAL",[78],"NA","This is a randomized, multi-center, open-label study in which patients with depression who responded to an open-label treatment with intermittent theta burst stimulation (iTBS) will receive this procedure as maintenance therapy. The patients will be randomized to two study arms. The arms differ in the frequency of stimulation (standard iTBS (5 treatments every working day for one week) vs. accelerated iTBS (5 treatments in one day)). For purposes of effect size estimation an interim analysis will be done after half of the patients.",[81],"Depression","2025-11-28",{"date":84,"type":85},"2025-12-01","ACTUAL",{"date":87,"type":85},"2023-04-25",{"date":89,"type":75},"2026-02-28",{"name":61,"class":6},1]