[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628794":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":35,"centralContacts":39,"locations":45,"responsibleParty":64,"collaborators":30,"id":66,"slug":67,"hasResults":68,"nctId":69,"briefTitle":70,"officialTitle":71,"acronym":30,"eligibilityCriteria":72,"healthyVolunteers":68,"sex":73,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":30,"studyType":79,"phases":80,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":47,"whyStopped":30,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":99},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Left PFC-iTBS","EXPERIMENTAL","Participants will receive active intermittent theta-burst stimulation (iTBS) targeting the left prefrontal cortex.",[13],"Device: Active Intermittent Theta-Burst Stimulation (iTBS)",{"label":15,"type":10,"description":16,"interventionNames":17},"Right PFC-iTBS","Participants will receive active intermittent theta-burst stimulation (iTBS) targeting the right prefrontal cortex.",[13],{"label":19,"type":20,"description":21,"interventionNames":22},"Sham iTBS","SHAM_COMPARATOR","Participants will receive sham intermittent theta-burst stimulation (iTBS) targeting the prefrontal cortex.",[23],"Device: Sham Intermittent Theta-Burst Stimulation (iTBS)",[25,31],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DEVICE","Active Intermittent Theta-Burst Stimulation (iTBS)","Active iTBS is delivered using a real \"figure-8\" coil targeting the prefrontal cortex. Stimulation is delivered at 120% of the resting motor threshold (RMT). The protocol consists of 3 sets of 50 Hz pulses repeated at 5 Hz (2s on, 8s off), totaling 1,800 pulses per session. The intensive treatment schedule includes 4 sessions per day for 5 consecutive days (1 week), totaling 20 sessions.",[9,15],null,{"type":26,"name":32,"description":33,"armGroupLabels":34,"otherNames":30},"Sham Intermittent Theta-Burst Stimulation (iTBS)","Sham iTBS is delivered using a visually identical sham \"figure-8\" coil. It produces similar acoustic clicks and scalp somatic sensations to mimic the active treatment, ensuring participant blinding. However, it uses same-direction currents causing opposing central currents, resulting in near-zero focal magnetic induction without therapeutic effect. The session schedule and apparent parameters strictly match the active group (4 sessions\u002Fday for 5 days).",[19],[36],{"name":37,"affiliation":5,"role":38},"Lei Lei Zheng, MD","PRINCIPAL_INVESTIGATOR",[40],{"name":41,"role":42,"phone":43,"phoneExt":30,"email":44},"Han Yang, PhD","CONTACT","+8613314590507","yang_han_life@163.com",[46],{"facility":5,"status":47,"city":48,"state":49,"zip":50,"country":51,"countryCode":52,"cosmosGeoPoint":53,"geoPoint":58,"contacts":59},"RECRUITING","Hangzhou","Zhejiang","310013","China","CN",{"type":54,"coordinates":55},"Point",[56,57],120.16142,30.29365,{"lat":57,"lon":56},[60],{"name":61,"role":42,"phone":62,"phoneExt":30,"email":63},"Zhiying MD Wu","+86 0571 87783759","keyanlunli_zheer@163.com",{"type":65,"investigatorFullName":30,"investigatorTitle":30,"investigatorAffiliation":30,"oldNameTitle":30,"oldOrganization":30},"SPONSOR","100628794","intermittent-theta-burst-stimulation-of-the-prefrontal-cortex-in-social-anxiety-disorder-100628794",false,"NCT07466277","Intermittent Theta Burst Stimulation of the Prefrontal Cortex in Social Anxiety Disorder","Intermittent Theta-Burst Stimulation Targeting the Prefrontal Cortex for Social Anxiety Disorder: A Randomized, Parallel-Group Comparative Study","Inclusion Criteria: Eligible participants must be right-handed individuals aged 16 to 70 years who meet the diagnostic criteria for Social Anxiety Disorder (SAD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). If participants are taking concurrent psychiatric medications, their dosage must have been stable for at least 4 weeks prior to enrollment. Additionally, all individuals must voluntarily agree to participate in the study and provide written informed consent.\n\nExclusion Criteria: Individuals will be excluded if they have a history of neurological disorders or other severe somatic diseases, including but not limited to seizures, central nervous system tumors, stroke, or brain aneurysms. Participants meeting DSM-5 diagnostic criteria for other primary psychiatric disorders-such as schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, depressive disorders, other anxiety disorders, obsessive-compulsive and related disorders, or somatic symptom and related disorders-are also ineligible. Furthermore, the study excludes those with metallic implants in the head or neck, any other clear contraindications to Transcranial Magnetic Stimulation (TMS), or a previous history of receiving TMS treatment, which is restricted to prevent potential unblinding. Finally, current use, or use within the past 4 weeks, of adequate doses of benzodiazepines for more than 2 weeks is an exclusion criterion, as it may limit the therapeutic efficacy of TMS.","ALL","16 Years","70 Years",{"count":77,"type":78},100,"ESTIMATED","INTERVENTIONAL",[81],"NA","This study aims to investigate the therapeutic effects of intermittent theta burst stimulation on social anxiety disorder and to track physiological changes in the brain using electroencephalography (EEG). Eligible SAD participants, after voluntarily signing an informed consent form, will first complete basic information collection, baseline questionnaire completion, and a pre-treatment EEG data collection session lasting approximately 30 minutes (including resting-state and task-state recordings). Subsequently, participants will be randomly assigned to one of three groups (left iTBS group, right iTBS group, or sham stimulation group) to receive intensive treatment for one week (4 sessions daily for 5 consecutive days, totaling 20 sessions). Immediately following the intervention, the research team will conduct post-treatment EEG data collection and gather questionnaire assessments. Participants will also undergo follow-up visits at weeks 2, 4, 6, and 8 post-treatment to complete questionnaires and report any adverse events. All study procedures are strictly and safely conducted by trained professionals. Participation is entirely voluntary, and participants may withdraw unconditionally at any time during the study.",[84],"Social Anxiety Disorder (SAD)",[86,87,88,89],"Social Anxiety Disorder","Transcranial Magnetic Stimulation","Intermittent Theta-Burst Stimulation","Prefrontal Cortex","2026-03-11",{"date":92,"type":93},"2026-03-12","ACTUAL",{"date":95,"type":93},"2025-12-09",{"date":97,"type":78},"2026-12-01",{"name":5,"class":6},1]