[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628225":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":10,"responsibleParty":26,"collaborators":30,"id":39,"slug":40,"hasResults":41,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":45,"eligibilityCriteria":46,"healthyVolunteers":41,"sex":47,"minAge":48,"maxAge":10,"enrollmentInfo":49,"targetDuration":52,"studyType":53,"phases":10,"briefSummary":54,"conditions":55,"keywords":57,"overallStatus":64,"whyStopped":10,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":10},{"fullName":5,"class":6},"European Society for Trauma and Emergency Surgery","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"All IMPEL patients",null,"All enrolled participants with mechanical large-bowel obstruction managed according to local standard-of-care practices.",[13],{"name":14,"affiliation":15,"role":16},"Gary A Bass, MD, PhD","University of Pennsylvania","STUDY_DIRECTOR",[18,23],{"name":19,"role":20,"phone":21,"phoneExt":10,"email":22},"Matteo M Cimino, MD","CONTACT","+393928811420","cimino.matteo@gmail.com",{"name":24,"role":20,"phone":10,"phoneExt":10,"email":25},"Gabriele Bellio, MD","gabrielebellio87@gmail.com",{"type":27,"investigatorFullName":28,"investigatorTitle":29,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Matteo Cimino","IMPEL Study Coordinator",[31,34,36,38],{"name":32,"class":33},"Association of Surgeons of Great Britain and Ireland","UNKNOWN",{"name":35,"class":33},"European Society of Coloproctology",{"name":37,"class":6},"American Society of Colon and Rectal Surgeons",{"name":15,"class":6},"100628225","international-multi-center-profile-of-emergency-large-bowel-obstruction-management-and-outcomes-100628225",false,"NCT07458867","International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes","International Multi-center Profile of Emergency Large-Bowel Obstruction Management and Outcomes (IMPEL)","IMPEL","Inclusion Criteria:\n\n* Age 18 years or older\n* Hospital admission with mechanical large-bowel obstruction, with or without associated perforation\n* Managed operatively or non-operatively according to local standard practice\n\nExclusion Criteria:\n\n* Functional or pseudo-obstruction without a mechanical lesion\n* Pediatric patients (\\\u003C18 years)\n* Patients not admitted to hospital\n* Isolated large-bowel perforation unrelated to obstruction","ALL","18 Years",{"count":50,"type":51},500,"ESTIMATED","6 Months","OBSERVATIONAL","Mechanical large-bowel obstruction is a common and high-risk emergency surgical condition with substantial variation in diagnostic evaluation, operative timing, and management strategies across institutions and healthcare systems. Evidence guiding optimal management remains limited and is largely derived from retrospective or single-center studies.\n\nIMPEL is an international, multicenter, time-bound, prospective observational cohort study designed to characterize real-world presentation, diagnostic pathways, operative and non-operative management, and short-term outcomes in adults presenting with mechanical large-bowel obstruction. By capturing standardized patient-level, radiologic, operative, and outcome data across diverse acute care settings, IMPEL aims to describe contemporary practice patterns, quantify variation in care, and identify factors associated with morbidity, mortality, and stoma-related outcomes.",[56],"Large Bowel Obstruction",[58,59,60,61,62,63],"Large-bowel obstruction","stoma","colonic obstruction","bridge to surgery","snapshot audit","observational cohort","NOT_YET_RECRUITING","2026-03-04",{"date":67,"type":68},"2026-03-09","ACTUAL",{"date":70,"type":51},"2026-07-01",{"date":72,"type":51},"2027-07-31",{"name":5,"class":6}]