[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633889":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":28,"centralContacts":33,"locations":43,"responsibleParty":82,"collaborators":85,"id":91,"slug":92,"hasResults":93,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":18,"eligibilityCriteria":97,"healthyVolunteers":93,"sex":98,"minAge":99,"maxAge":18,"enrollmentInfo":100,"targetDuration":18,"studyType":103,"phases":104,"briefSummary":106,"conditions":107,"keywords":110,"overallStatus":116,"whyStopped":18,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"National University of Singapore","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"iCBT intervention arm","EXPERIMENTAL","iCBT intervention arm: Participants undergo 8 weeks of 8 online modules (1 module per week) covering core CBT techniques, including interactive exercises and homework assignments delivered via the iCBT programme on a mobile application. COMIT counsellors will schedule regular check-ins with participants at Week 3, 5, and end of Week 8 via video or face-to-face sessions.",[13],"Behavioral: Internet-delivered cognitive behavioural therapy (iCBT)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control arm","NO_INTERVENTION","The control group will continue usual care, including but not limited to care from GP consultations, standard face-to-face CBT, and\u002For referral to other mental health services.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Internet-delivered cognitive behavioural therapy (iCBT)","Guided iCBT in Singapore for mild-to-moderate anxiety and\u002For depression",[9],[26,27],"iCBT","Guided iCBT",[29],{"name":30,"affiliation":31,"role":32},"Gerald C.H. Koh, MBBS, FCFP, PhD","Saw Swee Hock School of Public Health, National University of Singapore","PRINCIPAL_INVESTIGATOR",[34,39],{"name":35,"role":36,"phone":37,"phoneExt":18,"email":38},"Alvin K.Y. Neo, MBBS (Honours), MRCP (UK)","CONTACT","6597569541","alvin.neo@moht.com.sg",{"name":40,"role":36,"phone":41,"phoneExt":18,"email":42},"Nicole S.Y. Chia, BA(Communication & Psychology)","6581267277","nicole.chia@moht.com.sg",[44,60,71],{"facility":45,"status":18,"city":46,"state":18,"zip":47,"country":46,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"[Viriya] Mental Wellness Hub","Singapore","210052","SG",{"type":50,"coordinates":51},"Point",[52,53],103.85007,1.28967,{"lat":53,"lon":52},[56],{"name":57,"role":36,"phone":58,"phoneExt":18,"email":59},"Viriya","6562561311","mwh@viriya.org.sg",{"facility":61,"status":18,"city":46,"state":18,"zip":62,"country":46,"countryCode":48,"cosmosGeoPoint":63,"geoPoint":65,"contacts":66},"[Allkin] Integrated Service Centre @ Sengkang 193","540193",{"type":50,"coordinates":64},[52,53],{"lat":53,"lon":52},[67],{"name":68,"role":36,"phone":18,"phoneExt":69,"email":70},"Allkin","6560384400","mentalhealthservice@allkin.org.sg",{"facility":72,"status":18,"city":46,"state":18,"zip":73,"country":46,"countryCode":48,"cosmosGeoPoint":74,"geoPoint":76,"contacts":77},"[Fei Yue] Family Service Centre (Choa Chu Kang)","680280",{"type":50,"coordinates":75},[52,53],{"lat":53,"lon":52},[78],{"name":79,"role":36,"phone":80,"phoneExt":18,"email":81},"Fei Yue","6560117658","comit@fycs.org",{"type":32,"investigatorFullName":83,"investigatorTitle":84,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Gerald Koh","Principal Investigator",[86,89],{"name":87,"class":88},"Ministry of Health, Singapore","OTHER_GOV",{"name":90,"class":6},"Agency for Integrated Care, Singapore","100633889","internet-based-cognitive-behavioural-therapy-icbt-for-anxiety-and-depression-in-singapore-100633889",false,"NCT07532551","Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore","Assessing the Clinical and Cost Effectiveness of Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore","1. Quantitative Study - Patients\n\n   Inclusion Criteria:\n   * Age ≥21 years\n   * Tier 2 - 3 depression and\u002For anxiety based on PHQ-9 and GAD-7 scores\n\n     * PHQ-9 score of 5 to 19\n     * GAD-7 score of 5 to 14\n   * Able to provide informed consent\n\n   Exclusion Criteria:\n   * Unable to read or understand English (Primary 6 level)\n   * Unable to use the internet (e.g. due to lack of internet access or insufficient digital literacy)\n   * Does not possess a mobile device or is not able to access the iCBT application\n   * Actively experiencing psychosis\n   * Suspected with personality disorder\n   * Primary concern is obsessive compulsive disorder (OCD)\n   * Tier 4 patients with severe depression or anxiety\n\n     * PHQ-9 score of 20 and above\n     * GAD-7 score of 15 and above\n   * Any suicidal risk or ideation\n\n     * PHQ-9 Question 9 score of more than 2\n2. Qualitative Study - Service Providers\n\nInclusion Criteria:\n\n* Are currently or previously have been involved in the delivery, supervision, or implementation of the iCBT programme\n* Have had direct experience supporting patients enrolled in the study\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Have no direct involvement in the iCBT programme; or\n* Have had insufficient exposure to the programme, defined as managing fewer than one referred case or less than one month of involvement at the time of recruitment.\n* Conflict of interest or Supervisory Hierarchy Concerns - Individuals whose participation may create perceived coercion or introduce bias\n* Inability to provide informed consent","ALL","21 Years",{"count":101,"type":102},390,"ESTIMATED","INTERVENTIONAL",[105],"NA","Cognitive-behavioural therapy (CBT) has a robust evidence base for treating anxiety disorders and depression, including transdiagnostic CBT. Internet-based CBT (iCBT) offers a new approach to delivering these therapies. iCBT is a digital adaptation of traditional CBT that leverages digital platforms to deliver similar therapeutic interventions. iCBT encompasses structured programmes that provide users with tools and techniques to manage mental health issues such as depression and anxiety. The digital format ensures timely access to CBT and typically includes interactive modules, videos, self-assessment tools, and virtual therapist support. This study aims to evaluate the effectiveness of iCBT in reducing symptoms of anxiety and depression, as well as its cost-effectiveness and acceptability in local context.\n\nThe main questions it aims to answer are:\n\n1. Do participants receiving iCBT show a reduction in symptoms of anxiety and\u002For depression, and does the effectiveness of iCBT vary based on individual user characteristics?\n2. What are the factors that influence the acceptance, adoption, and engagement rates of iCBT among Singaporeans?\n3. Is iCBT more cost-effective as compared to usual care?\n\nResearchers will compare guided iCBT to usual care (traditional CBT) to assess iCBT's clinical effectiveness, cost-effectiveness, and acceptability in Singapore's primary and community healthcare settings.\n\nParticipants in the intervention group will:\n\n1. Undergo guided iCBT intervention consisting of 8 weeks of online modules covering core CBT techniques\n2. Counsellors will schedule 3 regular check-ins\n3. Questionnaires will be administered at 5 timepoints\n4. Selected participants will be invited for a semi-structured interview to assess their experiences with iCBT\n\nParticipants in the control group will:\n\n1. Continue usual care\n2. Questionnaires will be administered at 5 timepoints\n\nA parallel qualitative study involving service providers is required to contextualise trial findings, identify implementation barriers and enablers and inform national scale-up and policy decisions. It aims to explore service providers' experiences, perceptions and contextual factors influencing the implementation of iCBT within routine primary-care and community mental-health services participating in this trial.",[108,109],"Depression and\u002For Anxiety in the Mild-to-moderate Range","Cognitive Behavioral Therapy",[111,112,113,26,114,115],"internet-delivered cognitive behavioural therapy","cognitive behavioural therapy","CBT","anxiety","depression","NOT_YET_RECRUITING","2026-04-12",{"date":119,"type":120},"2026-04-16","ACTUAL",{"date":122,"type":102},"2026-04",{"date":124,"type":102},"2028-03",{"name":5,"class":6},3]