[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100636077":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":17,"locations":26,"responsibleParty":41,"collaborators":10,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":10,"enrollmentInfo":52,"targetDuration":10,"studyType":55,"phases":10,"briefSummary":56,"conditions":57,"keywords":10,"overallStatus":60,"whyStopped":10,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},{"fullName":5,"class":6},"University Hospital, Strasbourg, France","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Internuclear ophthalmoplegia",null,"This is a retrospective cohort study involving patients who have experienced internuclear ophthalmoplegia. For each patient, it is determined whether a diagnosis of multiple sclerosis was established or not.",[13],{"name":14,"affiliation":15,"role":16},"Kévin BIGAUT","Hôpitaux Universitaires de Strasbourg","PRINCIPAL_INVESTIGATOR",[18,22],{"name":14,"role":19,"phone":20,"phoneExt":10,"email":21},"CONTACT","+33 3 88 12 60 96","kevin.bigaut@chru-strasbourg.fr",{"name":23,"role":19,"phone":24,"phoneExt":10,"email":25},"Sebille COLIN","+33 3 88 11 52 17","sebille.colin@chru-strasbourg.fr",[27],{"facility":28,"status":10,"city":29,"state":10,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Les Hôpitaux Universitaires","Strasbourg","67 200","France","FR",{"type":34,"coordinates":35},"Point",[36,37],7.74553,48.58392,{"lat":37,"lon":36},[40],{"name":14,"role":19,"phone":10,"phoneExt":10,"email":21},{"type":42,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100636077","internuclear-ophthalmoplegia-and-multiple-sclerosis-a-multicenter-retrospective-study-100636077",false,"NCT07560995","Internuclear Ophthalmoplegia and Multiple Sclerosis: a Multicenter Retrospective Study","INO&MS","Inclusion criteria:\n\n* Patients with internuclear ophthalmoplegia listed as a primary or associated diagnosis\n* Patients hospitalized in a neurology department\n\nExclusion criteria:\n\n\\- Patients under 18 years of age","ALL","18 Years",{"count":53,"type":54},200,"ESTIMATED","OBSERVATIONAL","Internuclear ophthalmoplegia is a symptom frequently associated with multiple sclerosis (MS), although other etiologies are possible. Some patients do not meet the diagnostic criteria for MS at the time of the internuclear ophthalmoplegia episode but subsequently convert to MS. Studying this specific clinical situation may help enable earlier diagnosis of MS.\n\nThe objective is to analyze the proportion of patients with isolated internuclear ophthalmoplegia who convert to multiple sclerosis and to identify factors associated with this conversion.\n\nThe study hypothesis is that the presence of internuclear ophthalmoplegia is highly suggestive of multiple sclerosis, particularly when cerebrospinal fluid-specific oligoclonal bands are present.",[58,59],"Multiple Sclerosis","Internuclear Ophthalmoplegia","NOT_YET_RECRUITING","2026-05-04",{"date":63,"type":64},"2026-05-08","ACTUAL",{"date":66,"type":54},"2026-05",{"date":68,"type":54},"2027-05",{"name":5,"class":6},1]