[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100516735":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":25,"centralContacts":29,"locations":39,"responsibleParty":85,"collaborators":10,"id":87,"slug":88,"hasResults":89,"nctId":90,"briefTitle":91,"officialTitle":92,"acronym":93,"eligibilityCriteria":94,"healthyVolunteers":89,"sex":95,"minAge":96,"maxAge":10,"enrollmentInfo":97,"targetDuration":100,"studyType":101,"phases":10,"briefSummary":102,"conditions":103,"keywords":109,"overallStatus":42,"whyStopped":10,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Mayo Clinic","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: Germline and Somatic Testing",null,"Potential participants with a cancer diagnosis may be identified through the following sources: patients who will undergo or are currently undergoing clinical evaluation in practices such as, but not limited to, hematology-oncology, gastroenterology-hepatology, radiation-oncology and surgery. Participants will be enrolled in the study indefinitely unless a request to withdraw is made.",[13],"Genetic: Pan-genomic Testing",{"label":15,"type":10,"description":11,"interventionNames":16},"Group B: Germline Testing Only",[13],[18],{"type":19,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"GENETIC","Pan-genomic Testing","Participants will be scheduled to review the study specifics, review consent and gather medical information. Once consented, samples will be collected. When the samples are received by Exact Sciences, DNA and RNA will be extracted, and sequencing will be performed. Following pan-genomic testing, participants will receive the full report with results from their care team and results will also be added to the patient's portal. If a germline finding is identified (positive pathogenic variant) the participant will also be referred for a genetic counselor visit. All results from the germline hereditary test will be reviewed by a certified genetic counselor in addition to a review of their pedigree. To help with review of any genetic research findings, the study team may request to obtain genomic data from previous genetic testing (clinical or research based).",[9,15],[24],"Genetic testing",[26],{"name":27,"affiliation":5,"role":28},"Jewel J. Samadder, M.D.","PRINCIPAL_INVESTIGATOR",[30,35],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Clinical Trials Referral Office","CONTACT","855-776-0015","mayocliniccancerstudies@mayo.edu",{"name":36,"role":32,"phone":37,"phoneExt":10,"email":38},"Katie M. Gano, M.S.","480-342-6082","Gano.Katherine@mayo.edu",[40,57,71],{"facility":41,"status":42,"city":43,"state":44,"zip":45,"country":46,"countryCode":47,"cosmosGeoPoint":48,"geoPoint":53,"contacts":54},"Mayo Clinic in Arizona","RECRUITING","Scottsdale","Arizona","85259","United States","US",{"type":49,"coordinates":50},"Point",[51,52],-111.89903,33.50921,{"lat":52,"lon":51},[55,56],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"name":27,"role":28,"phone":10,"phoneExt":10,"email":10},{"facility":58,"status":42,"city":59,"state":60,"zip":61,"country":46,"countryCode":47,"cosmosGeoPoint":62,"geoPoint":66,"contacts":67},"Mayo Clinic in Florida","Jacksonville","Florida","32224",{"type":49,"coordinates":63},[64,65],-81.65565,30.33218,{"lat":65,"lon":64},[68,69],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"name":70,"role":28,"phone":10,"phoneExt":10,"email":10},"Jeremy C. Jones, M.D.",{"facility":72,"status":42,"city":73,"state":74,"zip":75,"country":46,"countryCode":47,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Mayo Clinic in Rochester","Rochester","Minnesota","55905",{"type":49,"coordinates":77},[78,79],-92.4699,44.02163,{"lat":79,"lon":78},[82,83],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"name":84,"role":28,"phone":10,"phoneExt":10,"email":10},"Mrinal S. Patnaik, M.B.B.S.",{"type":86,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100516735","interogating-cancer-for-etiology-prevention-and-therapy-navigation-100516735",false,"NCT06008392","INTERogating Cancer for Etiology, Prevention and Therapy Navigation","INTERogating Cancer for Etiology, Prevention and Therapy Navigation (INTERCEPTioN)","INTERCEPTioN","Inclusion Criteria:\n\nGROUP A: Germline and Somatic Testing\n\n* Has Mayo Clinic medical record number\n* Confirmed cancer diagnosis\n* Germline and\u002For somatic tumor\u002Fblood testing has been ordered by the clinical provider (or clinical delegate)\n* Participant aware of cancer diagnosis\n* Able to provide informed consent\n* ≥ 18 years old\n* Ability to provide blood, saliva, bone marrow aspirate or hair follicle sample\n* Ability to provide archived tissue, if somatic testing has not already been completed\n\n  * Note: if tissue unavailable participant may still enroll onto the study for the germline collection, or vice versa, if germline has already been completed may still enroll for somatic tissue\u002Fblood testing.\n\nGROUP B: Germline testing only:\n\n* Has Mayo Clinic medical record number\n* Confirmed cancer diagnosis\n* Germline testing has been ordered by the clinical provider (or clinical delegate)\n* Participant aware of cancer diagnosis\n* Able to provide informed consent\n* ≥ 18 years old\n* Ability to provide blood, saliva, or hair follicle sample\n\nGROUP C: Somatic tumor testing only:\n\n* Has Mayo Clinic medical record number,\n* Confirmed cancer diagnosis,\n* Somatic tumor\u002Fblood testing has been ordered by the clinical provider (or clinical delegate)\n* Participant aware of cancer diagnosis,\n* Able to provide informed consent,\n* ≥ 18 years old\n* Ability to provide archived tissue or blood for somatic tumor genomic profiling, if not already completed.\n\nGroup D: Clinical standard of care germline testing via genetic counselor:\n\n* Has Mayo Clinic medical record number,\n* Standard of care clinical visit with genetic counselor\n* Confirmed cancer diagnosis,\n* Germline testing has been ordered by the clinical provider (or clinical delegate)\n* Participant aware of cancer diagnosis,\n* Able to provide informed consent,\n* ≥ 18 years old\n* Ability to provide blood, saliva, or hair follicle sample\n\nGroup E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810:\n\n* Enrolled in any of the following studies: IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810\n* Completed Riskguard, OncoExtra, Caris Assure, or Caris MI Profile or any combination of these tests.\n* Has Mayo Clinic medical record number,\n* Confirmed cancer diagnosis,\n* Participant aware of cancer diagnosis\n* Able to provide informed consent,\n* ≥ 18 years old\n\nExclusion Criteria:\n\nNote: Women who are pregnant or planning to become pregnant can take part in this study.\n\nGROUP A: Germline and Somatic testing\n\n* Individuals who have situations that would limit compliance with the study requirements\n* Institutionalized (i.e. Federal Medical Prison)\n\nGROUP B: Germline testing only\n\n* Individuals who have situations that would limit compliance with the study requirements\n* Institutionalized (i.e. Federal Medical Prison)\n* Prior germline genetic testing with a 100+ multi-gene panel within the last 1 year of enrollment\n\nGroup C: Somatic tumor testing only:\n\n* Individuals who have situations that would limit compliance with the study requirements,\n* Institutionalized (i.e. Federal Medical Prison),\n\nGroup D: Clinical standard of care germline testing via genetic counselor:\n\n* Individuals who have situations that would limit compliance with the study requirements,\n* Institutionalized (i.e. Federal Medical Prison)\n\nGroup E: Previous Enrollment in IRB #24-005734, 24-000609, 25-000815, 23-001689, or 24-004810:\n\n* Individuals who have situations that would limit compliance with the study requirements,\n* Institutionalized (i.e. Federal Medical Prison)","ALL","18 Years",{"count":98,"type":99},500,"ESTIMATED","50 Years","OBSERVATIONAL","This study is being done to identify markers and causes of cancer by analyzing patient's DNA (i.e., genetic material), RNA, plasma, tissues, or other samples that could be informative for patients with cancer. Cancer genetic testing is a series of tests that finds specific changes in cancer cells and normal cells in the body. Researchers may request to access these data as they explore how to better prevent, screen, or treat cancer. This study is also being done to create a biobank (library) of samples and information to learn more about treating cancer. Discovery of genetic variants in patients with cancer could result in opportunities for cancer prevention, earlier diagnosis or better therapy for cancer.",[104,105,106,107,108],"Cancer","Cancer Gene Mutation","PAN Gene Mutation","Hematopoietic and Lymphoid System Neoplasm","Malignant Solid Neoplasm",[110,111,112,113,114],"Whole Exome Sequencing (WES)","Whole Genome Sequencing (WGS)","Genetic Testing","Genetic Counseling","Genomics","2026-04-06",{"date":117,"type":118},"2026-04-07","ACTUAL",{"date":120,"type":118},"2023-10-12",{"date":122,"type":99},"2033-09",{"name":5,"class":6},3]