[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100506214":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":30,"centralContacts":51,"locations":60,"responsibleParty":79,"collaborators":82,"id":96,"slug":97,"hasResults":98,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":104,"sex":105,"minAge":25,"maxAge":106,"enrollmentInfo":107,"targetDuration":25,"studyType":110,"phases":111,"briefSummary":113,"conditions":114,"keywords":25,"overallStatus":63,"whyStopped":25,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":126},{"fullName":5,"class":6},"Hanoi University of Public Health","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention district","ACTIVE_COMPARATOR","An information, communication, education and hygiene intervention, developed in collaboration with local health authorities, will aim to improve hygiene and decrease antibiotic use.",[13],"Behavioral: , Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention",{"label":15,"type":10,"description":16,"interventionNames":17},"cohort care at the hospital","A laminated note (yellow for \"suspicious CRE carrier\": green for (CRE-) patients and red for (CRE+) patients) should be put on the front of the patients' bed.",[18],"Behavioral: Hospital Cohort Care Intervention at the hospital",[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Hospital Cohort Care Intervention at the hospital","There will be 3 different cohort groups for the patients: 1) Unknown CRE colonisation status with increased barrier precautions (all patients until screening results arrive will belong to this group unless there are available screening results from referral hospital), 2) CREpos, and 3) CREneg. CREpos patients (2) will be treated in one area of the ICUs by specially assigned nurses\u002Fpersonnel.",[15],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},", Household Education Communication Hygiene Intervention, Livestock Antibiotic Intervention","The intervention will focus on two main measurable outcomes: 1) Decrease feco-oral-animal transmission route to prevent in-HH and community spread of CRE +\u002F- CoRE. 2) Decrease unindicated community use of ABs for humans and animals. This WP focuses on a one health intervention in collaboration with local health authorities, developing and implementing an HH Education Communication Hygiene Intervention (HECHI) to improve HH hygiene and health management and reduce the risk of transmission between humans and animals, a Provider Engagement Intervention (PEI) to improve case management of common infection and decrease unindicated AB, and and a Livestock AB Intervention (LAI) to reduce the use of AB in livestock through improved biosecurity conditions and animal husbandry.",[9],[31,35,38,42,45,48],{"name":32,"affiliation":33,"role":34},"Mattias Larsson, MD","Karolinska Institutet","PRINCIPAL_INVESTIGATOR",{"name":36,"affiliation":37,"role":34},"Thirumalaisamy Velavan, PhD","University of Tübingen, Germany",{"name":39,"affiliation":40,"role":41},"Håkan Hanberger","Linkoeping University","STUDY_DIRECTOR",{"name":43,"affiliation":44,"role":34},"Flavie Goutard, PhD","CIRAD, France",{"name":46,"affiliation":47,"role":34},"Yaovi Mahuton Gildas Hounmanou, PhD","University of Copenhagen",{"name":49,"affiliation":50,"role":34},"Minh-Dien Tran","Vietnam National Children's Hospital",[52,57],{"name":53,"role":54,"phone":55,"phoneExt":25,"email":56},"Phuc Pham-Duc, MD, PhD","CONTACT","84904049969","pdp@huph.edu.vn",{"name":58,"role":54,"phone":25,"phoneExt":25,"email":59},"Viet-Linh Nguyen, BVetMed, PhD","vietlinh1603@gmail.com",[61],{"facility":62,"status":63,"city":64,"state":65,"zip":66,"country":67,"countryCode":68,"cosmosGeoPoint":69,"geoPoint":74,"contacts":75},"Thai Binh Pediatric Hospital","RECRUITING","Thái Bình","Thai Binh","06122","Vietnam","VN",{"type":70,"coordinates":71},"Point",[72,73],106.34002,20.45,{"lat":73,"lon":72},[76],{"name":77,"role":54,"phone":78,"phoneExt":25,"email":25},"Thi Nhu Pham, MD","0986155211",{"type":34,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Pham-Duc Phuc","Deputy Director of Center for Public Health and Ecosystem Research",[83,85,86,88,89,91,94],{"name":40,"class":84},"OTHER_GOV",{"name":33,"class":6},{"name":87,"class":6},"Universität Tübingen",{"name":47,"class":6},{"name":90,"class":6},"National Children's Hospital, Vietnam",{"name":92,"class":93},"Centre de coopération internationale en recherche agronomique pour le développement (CIRAD)","UNKNOWN",{"name":95,"class":93},"International Centre for Antimicrobial Resistance Solutions","100506214","interventions-to-decrease-cre-colonization-and-transmission-between-hospitals-households-communities-and-domesticated-animals-100506214",false,"NCT05871476","Interventions to Decrease CRE Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals","Interventions to Decrease Carbapenem Resistant Enterobacteriaceae Colonization and Transmission Between Hospitals, Households, Communities and Domesticated Animals","I-CRECT","Inclusion Criteria:\n\n* All patients under 2 years old at the selected hospital are highly appreciated to join the study.\n\nExclusion Criteria:\n\n* Patients not from the selected hospital and individuals outside the selected province",true,"ALL","24 Months",{"count":108,"type":109},800,"ESTIMATED","INTERVENTIONAL",[112],"NA","Carbapenem resistant Enterobacteriaceae (CRE) colonization of patients discharged from hospitals is a source of transmission to the community. In a cluster randomized controlled trial the effect of a bundle of interventions will be assessed on CRE transmission from CRE+ index patient discharged from hospital to HouseHold (HH) members. The districts in two provinces will be randomized to intervention or control. An information, communication, education and hygiene intervention, developed in collaboration with local health authorities, will aim to improve hygiene and decrease antibiotic (AB) use. The effect will be evaluated on CRE transmission between HH members, livestock and environment through consecutive CRE screening using fecal and hospital effluent samples cultured on carbapenem selective media. Knowledge, Attitudes, Practice surveys with smartphones will assess health seeking, AB use and hygiene adherence, hence detecting the effect of interventions. If transmission of CRE +\u002F- Colistin Resistant Enterobacteriaceae (CoRE, common among livestocks) is detected the source will be investigated including livestock and food, targeted information will be given and evaluated. In hospitals the effect of cohort care will be assessed on CRE acquisition, hospital acquired infection, treatment outcome, costeffectiveness and contamination in sewage water. Mechanisms of resistance, relatedness of CRE isolates in different One Health departments, and rate of CRE transmission from humans to animals and vice versa, will be assessed through Whole Genome Sequencing (WGS).",[115,116],"Antibiotic Resistant Infection","Carbapenem-Resistant Enterobacteriaceae Infection","2025-06-18",{"date":119,"type":120},"2025-06-24","ACTUAL",{"date":122,"type":120},"2022-07-01",{"date":124,"type":109},"2026-06-30",{"name":5,"class":6},1]