[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100552106":3},{"organization":4,"armGroups":7,"interventions":30,"overallOfficials":39,"centralContacts":44,"locations":49,"responsibleParty":64,"collaborators":10,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":10,"eligibilityCriteria":73,"healthyVolunteers":74,"sex":75,"minAge":76,"maxAge":10,"enrollmentInfo":77,"targetDuration":10,"studyType":80,"phases":10,"briefSummary":81,"conditions":82,"keywords":87,"overallStatus":51,"whyStopped":10,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},{"fullName":5,"class":6},"Oslo University Hospital","OTHER",[8,14,18,21,24,27],{"label":9,"type":10,"description":11,"interventionNames":12},"Median arcuate ligament syndrome (MALS)",null,"Patients with MALS Scheduled for laparoskopic decompression.",[13],"Procedure: Laparoscopic surgery",{"label":15,"type":10,"description":16,"interventionNames":17},"Chronic mesenteric ischemia (CMI)","Patients with CMI caused by atherosclerotic stenosis or occlusion of celiac artery, superior mesenteric artery ( one or both arteries ), and scheduled treatment with either PTA\u002Fstent or mesenteric bypass.",[13],{"label":19,"type":10,"description":20,"interventionNames":10},"Morbus Crohn intestine","Patients with diagnosed Mb Crohn of intestine who does not have CMI or MALS excluded with duplex ultrasound.",{"label":22,"type":10,"description":23,"interventionNames":10},"Cholilithiasis","Patients with diagnosed Cholilithiasis who is scheduled for operative chelecystectomy and does not have CMI or MALS, excluded with the help of duplex ultrasound.",{"label":25,"type":10,"description":26,"interventionNames":10},"Blood donor (Young)","Healthy blood donor with a median age of 45 years, who does not have symptoms of mesenteric ischemia or MALS and has excluded these two conditions with the help of duplex ultrasound.",{"label":28,"type":10,"description":29,"interventionNames":10},"Blood donor (Old)","Healthy blood donor with a median age of 70 years, who does not have symptoms of mesenteric ischemia or MALS and has excluded these two conditions with the help of duplex ultrasound.",[31],{"type":32,"name":33,"description":34,"armGroupLabels":35,"otherNames":36},"PROCEDURE","Laparoscopic surgery","The patients in the MALS group will be treated through transperitoneal ventral approach for the laparoscopic release of the celiac artery. Median arcuate ligament and any muscle or nerve tissue crossing the cranial surface of the celiac artery will be divided to release the celiac artery from compression.\n\nIn the patients with CMI open antegrade or retrograde bypass to celiac artery or superior mesenteric artery or both will be performed.\n\nFor operative treatment will be performed in general anaethesia whereas the endovacular treatment with PTA with stent for CMI will be performed in local anaethesia.",[15,9],[37,38],"Percutaneous transluminal angioplasty (PTA) with stent","Open mesenteric bypass",[40],{"name":41,"affiliation":42,"role":43},"Syed Sajid Hussain Kazmi, MD, PhD","Department of vascular surgery, Oslo University Hospital","PRINCIPAL_INVESTIGATOR",[45],{"name":41,"role":46,"phone":47,"phoneExt":10,"email":48},"CONTACT","4792468309","sshkazmi@gmail.com",[50],{"facility":42,"status":51,"city":52,"state":52,"zip":10,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":61},"RECRUITING","Oslo","Norway","NO",{"type":56,"coordinates":57},"Point",[58,59],10.74609,59.91273,{"lat":59,"lon":58},[62],{"name":41,"role":46,"phone":63,"phoneExt":10,"email":48},"004792468309",{"type":43,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Syed Sajid Hussain Kazmi","Principal Investigator","100552106","intestinal-ischemia-biomarker-in-patients-with-chronic-mesenteric-ischemia-100552106",false,"NCT06468774","Intestinal Ischemia Biomarker in Patients With Chronic Mesenteric Ischemia","Intestinal Ischemia Biomarker and Quality of Life of the Patients With Chronic Mesenteric Ischemia and Median Arcuate Ligament Syndrome","Inclusion Criteria: Above 18 years and has given informed written consent for treatment and study participation\n\nFor the patient groups :\n\nGroup 1: Has CTA or ultrasound diagnosed MALS and is scheduled operative treatment.\n\nGroup 2: Has CTA or ultrasound diagnosed CMI and is scheduled operative or endovascular treatment.\n\nFor the control group:\n\nGroup 3- Has ultrasound based diagnosis of cholelithiasis and is scheduled for cholecystectomy.\n\nGroup 4- Has established Mb Crohn diagnosis and under gastric lab follow-up. Group 5- Young healthy blood donors of mean age 45 years and has excluded MALS or CMi with ultrasound.\n\nGroup 6- Healthy blood donors of mean age 70 years and has excluded MALS or CMi with ultrasound.\n\nExclusion Criteria: Age less than 18 years Has nor given written consent.\n\n\\-",true,"ALL","18 Years",{"count":78,"type":79},180,"ESTIMATED","OBSERVATIONAL","Plasma Alpha glutathione S transferase (Alpha GST) has been previously demonstrated to be raised in patients with chronic mesenteric ischemia (CMI) caused by atherosclerosis and in patients with median arcuate ligament syndrome (MALS). Raised plasma level of Alpha GST has been demonstrated to decrease or normalize after surgical treatment of patients with CMI and MALS as compared with healthy individuals.\n\nThis study compares the plasma Alpha GST in patients with CMI and MALS with those with 1-Morbus Crohn, 2-Gallstone disease, and age-matched healthy individuals.\n\nBesides, changes in the health-related quality of life (QoL) will be investigated in the study individuals.",[83,84,85,86],"Chronic Mesenteric Ischemia","Median Arcuate Ligament Syndrome","Crohn Disease","Cholelithiasis",[88,89,90,91],"Intestinal ishchemia biomarker","alpha GST","MALS","Chronic mesenteric ischemia","2025-07-29",{"date":94,"type":95},"2025-07-30","ACTUAL",{"date":97,"type":95},"2024-06-10",{"date":99,"type":79},"2037-05-31",{"name":5,"class":6},1]