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Study by Pr BURGEL and\u002For MODUL CF).\n\nExclusion Criteria:\n\n* Start of treatment with elexacaftor\u002Ftezacaftor\u002Fivacaftor as part of a therapeutic trial.\n* Patient already on CFTR modulator (including lumacaftor\u002Fivacaftor)\n* Vulnerable people (pregnant woman, person under guardianship\u002Fcurators)","ALL","6 Years","17 Years",{"count":212,"type":213},253,"ESTIMATED","INTERVENTIONAL",[216],"NA","Cystic fibrosis is a systemic disease, which affects in particular the respiratory and digestive systems of patients, sites of chronic inflammation.\n\nA new combination of elexacaftor\u002Ftezacaftor\u002Fivacaftor has proven its efficacy for the treatment of patients aged 12 years and over with two F508del mutations or a so-called \"minimal function\" mutation associated with one F508del mutation. European marketing authorization was obtained in August 2020 and access in France should therefore arrive soon. Given that this treatment targets new mutations and that the efficacy seems greater than with LUM\u002FIVA, it is important to assess its impact on the microbiota and the pulmonary and digestive inflammation of patients.\n\nIt is therefore a question of taking advantage of the experience of the Lum-Iva-Biota cohort, and the validated and operational sample circuit established in the various participating centers to set up a biological collection for the collection and storage of sputum and stools of patients during the first year of treatment with elexacaftor\u002Ftezacaftor\u002Fivacaftor, in order to study the effect of treatment on the lung and digestive microbiota\u002Fmycobiota and inflammation.",[219],"Cystic Fibrosis",[221,222],"elexacaftor\u002Ftezacaftor\u002Fivacaftor","lung and digestive microbiota and inflammation","2026-06-18",{"date":225,"type":226},"2026-06-22","ACTUAL",{"date":228,"type":226},"2021-09-13",{"date":230,"type":213},"2026-09-13",{"name":5,"class":6},15]