[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623003":3},{"organization":4,"armGroups":7,"interventions":26,"overallOfficials":32,"centralContacts":42,"locations":32,"responsibleParty":48,"collaborators":32,"id":51,"slug":52,"hasResults":53,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":32,"eligibilityCriteria":57,"healthyVolunteers":53,"sex":58,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":32,"studyType":64,"phases":65,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":73,"whyStopped":32,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":32},{"fullName":5,"class":6},"First People's Hospital of Hangzhou","OTHER",[8,14,20],{"label":9,"type":10,"description":11,"interventionNames":12},"SSRI Tapering Group","ACTIVE_COMPARATOR","Participants receive standard SSRI dose reduction or discontinuation under psychiatric supervision for 8 weeks.",[13],"Drug: Selective Serotonin Reuptake Inhibitors (SSRIs)",{"label":15,"type":16,"description":17,"interventionNames":18},"SSRI Tapering + Sham Intradermal Acupuncture","SHAM_COMPARATOR","Participants receive standard SSRI tapering combined with sham intradermal acupuncture for 8 weeks.",[13,19],"Procedure: Sham Intradermal Acupuncture",{"label":21,"type":22,"description":23,"interventionNames":24},"SSRI Tapering + Intradermal Acupuncture","EXPERIMENTAL","Participants receive standard SSRI tapering combined with intradermal acupuncture for 8 weeks.",[13,25],"Procedure: Intradermal Acupuncture",[27,33,38],{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"DRUG","Selective Serotonin Reuptake Inhibitors (SSRIs)","Participants will receive only standard oral SSRI antidepressant dose reduction, with dosage adjustments determined by a specialist physician, for a duration of 8 weeks.",[21,15,9],null,{"type":34,"name":35,"description":36,"armGroupLabels":37,"otherNames":32},"PROCEDURE","Sham Intradermal Acupuncture","The sham intradermal needles are identical to the intradermal acupuncture needles in size, color, and material, with the needle body replaced by a thin silicone pad. The sham needles are applied to the selected acupoints and retained for 72 hours, followed by a 1-day rest period after removal. Acupoints: Shenmen (HT 7), Neiguan (PC 6), Sanyinjiao (SP 6), and Taichong (LR 3).",[15],{"type":34,"name":39,"description":40,"armGroupLabels":41,"otherNames":32},"Intradermal Acupuncture","According to the location of the acupoints, intradermal acupuncture needles (φ0.20 × 1.5 mm or φ0.20 × 1.2 mm) are inserted vertically into the skin while avoiding blood vessels and retained for 72 hours, followed by a 1-day rest period after removal. During the retention period, participants are instructed to press the needles 3-4 times daily, with each stimulation lasting approximately 1 minute and an interval of 4 hours between sessions; the stimulation intensity is limited to the maximum level tolerated by the participant. Acupoints: Shenmen (HT 7), Neiguan (PC 6), Sanyinjiao (SP 6), and Taichong (LR 3).",[21],[43],{"name":44,"role":45,"phone":46,"phoneExt":32,"email":47},"Mingqi Tu","CONTACT","+86 15700067213","403712321@qq.com",{"type":49,"investigatorFullName":44,"investigatorTitle":50,"investigatorAffiliation":5,"oldNameTitle":32,"oldOrganization":32},"PRINCIPAL_INVESTIGATOR","Doctor of Philosophy","100623003","intradermal-acupuncture-for-assisting-ssri-dose-reduction-in-major-depressive-disorder-100623003",false,"NCT07390981","Intradermal Acupuncture for Assisting SSRI Dose Reduction in Major Depressive Disorder","Clinical Efficacy of Intradermal Acupuncture as an Adjunct to SSRI Dose Reduction or Discontinuation in Patients With Major Depressive Disorder and Its Mechanisms of Autonomic Nervous System Regulation","Inclusion Criteria:\n\n* Adults aged 18-60 years\n\nDiagnosis of major depressive disorder according to DSM-5\n\nCurrently receiving SSRI treatment and planning gradual dose reduction or discontinuation\n\nClear consciousness and ability to communicate normally\n\nWillingness to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Severe uncontrolled primary medical conditions\n\nDepression secondary to substances, medical illness, other psychiatric disorders (e.g., bipolar disorder, schizophrenia), or major bereavement\n\nActive suicidal ideation\n\nPregnancy or lactation\n\nCognitive impairment\n\nBleeding disorders or allergy to adhesive materials\n\nParticipation in another clinical trial within the past month","ALL","18 Years","60 Years",{"count":62,"type":63},114,"ESTIMATED","INTERVENTIONAL",[66],"NA","This randomized controlled trial aims to evaluate the clinical efficacy of intradermal acupuncture as an adjunctive intervention to assist selective serotonin reuptake inhibitor (SSRI) dose reduction or discontinuation in adult patients with major depressive disorder (MDD). Participants receiving SSRIs and planning gradual dose reduction or discontinuation will be randomly assigned to one of three groups: SSRI tapering alone, sham intradermal acupuncture plus SSRI tapering, or intradermal acupuncture plus SSRI tapering. Clinical outcomes and autonomic nervous system function will be assessed to determine the effectiveness and potential mechanisms of intradermal acupuncture in facilitating SSRI reduction and alleviating withdrawal-related symptoms.",[69],"Major Depressive Disorder",[39,71,72],"SSRIs","Heart Rate Variability","NOT_YET_RECRUITING","2026-03-23",{"date":76,"type":77},"2026-03-25","ACTUAL",{"date":79,"type":63},"2026-03-01",{"date":81,"type":63},"2028-12-31",{"name":5,"class":6}]