[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641359":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":12,"locations":19,"responsibleParty":33,"collaborators":10,"id":37,"slug":38,"hasResults":39,"nctId":40,"briefTitle":41,"officialTitle":42,"acronym":10,"eligibilityCriteria":43,"healthyVolunteers":39,"sex":44,"minAge":10,"maxAge":10,"enrollmentInfo":45,"targetDuration":48,"studyType":49,"phases":10,"briefSummary":50,"conditions":51,"keywords":54,"overallStatus":59,"whyStopped":10,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},{"fullName":5,"class":6},"Ippokrateio General Hospital of Thessaloniki","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"Adult Liver Transplant Recipients Undergoing Intraoperative VOT\u002FNIRS Monitoring",null,"Adult patients undergoing orthotopic liver transplantation will be enrolled in this observational cohort. During surgery, they will undergo standardized Vascular Occlusion Tests using Near-Infrared Spectroscopy to assess peripheral tissue oxygen saturation and microcirculatory reactivity. Measurements will be performed at predefined intraoperative timepoints, including baseline, anhepatic, neohepatic and final phases. Reoxygenation slope, hyperemic area under the curve and related parameters will be analyzed for their association with early allograft dysfunction and postoperative outcomes.",[13],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},"Dimitrios Zafeiriadis, MD","CONTACT","+306980422306","+30","imdzaf@gmail.com",[20],{"facility":5,"status":10,"city":21,"state":21,"zip":22,"country":23,"countryCode":24,"cosmosGeoPoint":25,"geoPoint":30,"contacts":31},"Thessaloniki","54642","Greece","GR",{"type":26,"coordinates":27},"Point",[28,29],22.93493,40.64072,{"lat":29,"lon":28},[32],{"name":14,"role":15,"phone":16,"phoneExt":17,"email":18},{"type":34,"investigatorFullName":35,"investigatorTitle":36,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Dimitrios Zafeiriadis","Dimitrios Zafeiriadis MD, Principal Investigator","100641359","intraoperative-assessment-of-microcirculatory-function-using-vascular-occlusion-test-during-liver-transplantation-100641359",false,"NCT07658794","Intraoperative Assessment of Microcirculatory Function Using Vascular Occlusion Test During Liver Transplantation","The Predictive Value of the Vascular Occlusion Test During Orthotopic Liver Transplantation for the Development of Early Allograft Dysfunction","Inclusion Criteria:\n\n* Adult patients aged 18 years or older\n* Patients scheduled to undergo orthotopic liver transplantation\n* Ability to obtain intraoperative Near-Infrared Spectroscopy measurements\n* Written informed consent obtained before enrollment\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Refusal or inability to provide informed consent\n* Emergency liver transplantation without sufficient time for enrollment\n* Inability to perform the Vascular Occlusion Test or obtain reliable NIRS measurements\n* Severe peripheral vascular disease or local upper-limb conditions interfering with monitoring","ALL",{"count":46,"type":47},50,"ESTIMATED","30 Days","OBSERVATIONAL","Early allograft dysfunction (EAD) remains one of the most important complications following orthotopic liver transplantation (OLT). Currently, there is no established intraoperative biomarker that reliably predicts graft dysfunction at an early stage. Near-infrared spectroscopy (NIRS) combined with the vascular occlusion test (VOT) is a non-invasive method for assessing tissue oxygenation and microcirculatory reserve. This prospective observational study aims to investigate whether VOT-derived parameters, including desaturation slope, recovery slope and post-ischemic hyperemic area under the curve (AUC-H), can predict EAD in liver transplant recipients. Measurements will be performed at four predefined intraoperative timepoints: after induction of anesthesia, during the anhepatic phase, during the neohepatic phase and at the end of surgery. The primary outcome is the occurrence of EAD according to Olthoff criteria.",[52,53],"Liver Cirrhosis","Early Allograft Dysfunction",[55,56,53,57,58],"Vascular Occlusion Test","Near-Infrared Spectroscopy","Liver Transplantation","Microcirculation","NOT_YET_RECRUITING","2026-06-27",{"date":62,"type":63},"2026-07-01","ACTUAL",{"date":65,"type":47},"2026-06",{"date":67,"type":47},"2027-06",{"name":5,"class":6},1]