[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633134":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":29,"centralContacts":36,"locations":42,"responsibleParty":66,"collaborators":29,"id":70,"slug":71,"hasResults":72,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":29,"eligibilityCriteria":76,"healthyVolunteers":72,"sex":77,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":29,"studyType":83,"phases":84,"briefSummary":86,"conditions":87,"keywords":29,"overallStatus":44,"whyStopped":29,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Group I","EXPERIMENTAL","Patients will receive intrathecal hyperbaric bupivacaine 15 mg, supplemented with dexmedetomidine 4 μg.",[13],"Drug: Dexmedetomidine 4 μg",{"label":15,"type":10,"description":16,"interventionNames":17},"Group II","Patients will receive intrathecal hyperbaric bupivacaine 15 mg, supplemented with dexmedetomidine 8 μg.",[18],"Drug: Dexmedetomidine 8 μg",{"label":20,"type":10,"description":21,"interventionNames":22},"Group III","Patients will receive intrathecal hyperbaric bupivacaine 15 mg, supplemented with dexmedetomidine 12 μg.",[23],"Drug: Dexmedetomidine 12 μg",[25,30,33],{"type":26,"name":27,"description":11,"armGroupLabels":28,"otherNames":29},"DRUG","Dexmedetomidine 4 μg",[9],null,{"type":26,"name":31,"description":16,"armGroupLabels":32,"otherNames":29},"Dexmedetomidine 8 μg",[15],{"type":26,"name":34,"description":21,"armGroupLabels":35,"otherNames":29},"Dexmedetomidine 12 μg",[20],[37],{"name":38,"role":39,"phone":40,"phoneExt":29,"email":41},"Ahmed A Ismail, MSc","CONTACT","00201115746779","ahmed.ali39348@postgrad.kasralainy.edu.eg",[43],{"facility":5,"status":44,"city":45,"state":29,"zip":46,"country":47,"countryCode":48,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"RECRUITING","Cairo","12613","Egypt","EG",{"type":50,"coordinates":51},"Point",[52,53],31.24967,30.06263,{"lat":53,"lon":52},[56,57,60,62,64],{"name":38,"role":39,"phone":40,"phoneExt":29,"email":41},{"name":58,"role":59,"phone":29,"phoneExt":29,"email":29},"Osama M Asaad, MD","SUB_INVESTIGATOR",{"name":61,"role":59,"phone":29,"phoneExt":29,"email":29},"Sheerin R Hamza, MD",{"name":63,"role":59,"phone":29,"phoneExt":29,"email":29},"Dalia K Abdelkader, MD",{"name":65,"role":59,"phone":29,"phoneExt":29,"email":29},"Ayman A Abougabal, MD",{"type":67,"investigatorFullName":68,"investigatorTitle":69,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"PRINCIPAL_INVESTIGATOR","Ahmed Abdou Ali Ismail","Assistant Lecturer of Anaesthesia, Surgical ICU, and Pain, Cairo University, Cairo, Egypt.","100633134","intrathecal-dexmedetomidine-with-bupivacaine-in-patients-undergoing-knee-orthopedic-surgery-100633134",false,"NCT07522736","Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery","The Analgesic Effect of Intrathecal Dexmedetomidine With Bupivacaine, in Patients Undergoing Knee Orthopedic Surgery: A Randomized Double-Blinded Dose-Finding Trial","Inclusion Criteria:\n\n* Age from 18 to 65 years.\n* American Society of Anesthesiologists (ASA) physical status I-II.\n* Male patients scheduled for knee orthopedic surgery.\n\nExclusion Criteria:\n\n* Patients with psychiatric disorders.\n* History of drug addiction.\n* Contraindication for regional anesthesia.\n* History of hypersensitivity to the study drugs.\n* Previous administration of opioids and\u002For other central nervous system depressants during current hospital admission.","ALL","18 Years","65 Years",{"count":81,"type":82},120,"ESTIMATED","INTERVENTIONAL",[85],"NA","This study aims to compare the duration of analgesia (as the primary outcome) and adverse effects (as the secondary outcome) after intrathecal administration of dexmedetomidine with hyperbaric bupivacaine to patients undergoing knee orthopedic surgery.",[88,89,90],"Intrathecal Dexmedetomidine","Bupivacaine","Knee Orthopedic Surgery","2026-04-04",{"date":93,"type":94},"2026-04-13","ACTUAL",{"date":96,"type":94},"2025-03-01",{"date":98,"type":82},"2026-08-30",{"name":5,"class":6},1]