[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100559730":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":43,"responsibleParty":62,"collaborators":37,"id":64,"slug":65,"hasResults":66,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":66,"sex":72,"minAge":73,"maxAge":37,"enrollmentInfo":74,"targetDuration":37,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":84,"overallStatus":46,"whyStopped":37,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"First Affiliated Hospital Xi'an Jiaotong University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IVUS-guidance PCI","EXPERIMENTAL","In the IVUS-guidance group, the optimal stent deployment criteria for non-left main lesion will include the following: : (1) the minimal lumen area (MLA) in the stented segment \\> 5.0 mm\\^2 or \\> 90% of the MLA at the distal reference segments, (2) plaque burden 5 mm proximal or distal to the stent edge is \\\u003C 55%, and (3) absence of medial dissection over 3 mm in length. In the setting of a two-stent approach for distal left main bifurcation lesions, the optimal stent deployment criteria are an absolute minimal stent area (MSA) greater than 8 mm\\^2 for the left main, greater than 7 mm\\^2 for carina, greater than 6 mm\\^2 for the ostial or proximal left anterior descending artery, and greater than 5 mm\\^2 for the ostial or proximal left circumflex artery. For left main lesion treated with single-stent technique, the criteria are greater than 7mm\\^2 for distal and greater than 8mm\\^2 for proximal. Further treatment will be required if the criteria are not met.",[13],"Procedure: Percutaneous coronary intervention",{"label":15,"type":16,"description":17,"interventionNames":18},"Angiography-guidance PCI","ACTIVE_COMPARATOR","Angiographic success is defined as thrombolysis in myocardial infarction (TIMI) flow grade 3, and residual stenosis \\\u003C 20%.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"PROCEDURE","Percutaneous coronary intervention","PCI with DES implantation",[15,9],[26],"PCI",[28],{"name":29,"affiliation":30,"role":31},"Ning Guo","The First Affiliated of Xi'an Jiaotong University","PRINCIPAL_INVESTIGATOR",[33,39],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},"Ning Guo, PhD,MD","CONTACT","+86 13991229101",null,"nguomd@mail.xjtu.edu.cn",{"name":40,"role":35,"phone":41,"phoneExt":37,"email":42},"Xin Huang, PhD,MD","+86 13571961135","hearthx@126.com",[44],{"facility":45,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"The First Affiliated Hopital of Xi'an Jiaotong University","RECRUITING","Xi'an","Shaanxi","710061","China","CN",{"type":53,"coordinates":54},"Point",[55,56],108.92861,34.25833,{"lat":56,"lon":55},[59,60,61],{"name":34,"role":35,"phone":36,"phoneExt":37,"email":38},{"name":40,"role":35,"phone":41,"phoneExt":37,"email":42},{"name":34,"role":31,"phone":37,"phoneExt":37,"email":37},{"type":63,"investigatorFullName":37,"investigatorTitle":37,"investigatorAffiliation":37,"oldNameTitle":37,"oldOrganization":37},"SPONSOR","100559730","intravascular-ultrasound-guided-pci-in-patients-with-chronic-kidney-disease-100559730",false,"NCT06567938","Intravascular Ultrasound-Guided PCI in Patients With Chronic Kidney Disease","Intravascular Ultrasound-Guided or Angiography-Guided Percutaneous Coronary Intervention in Patients With Chronic Kidney Disease: The IVUS-CKD Trial","IVUS-CKD","Inclusion Criteria:\n\n* CKD patients with eGFR\\\u003C60 mL\u002Fmin\u002F1.73 m\\^2\n* De novo coronary lesion suitable for second-generation metallic drug-eluting stent placement and IVUS imaging\n* Signed written informed consent\n\nExclusion Criteria:\n\n* Onset of STEMI within 24 hours or emergent angiography\n* Pregnant or childbearing women\n* Co-morbidity with an estimated life expectancy of \\\u003C 1 year\n* LVEF ≤ 30%\n* Cardiogenic shock or hemodynamic instability\n* Severe hepatic dysfunction, defined as ALT or AST more than 5 times the ULN\n* PCI within the previous 12 months\n* Target lesion of stent thrombosis or in-stent restenosis\n* Any planned non-cardiac surgery within 12 months\n* Inability to follow the protocol and comply with follow-up requirements or any other reason that the investigator feels would place the patient at increased risk\n* Current enrolment in other clinical trials\n* Contraindication to anti-platelet agents\n* History of intracranial or gastrointestinal bleeding requiring transfusion or surgical intervention for control (excluding hemorrhoid)\n* Chronic total occlusion lesion with unsuccessful guidewire crossing\n* Current intake of nephrotoxic medications (e.g., nonsteroidal anti-inflammatory drugs except acetylsalicylic acid, phenylbutazone, aminoglycosides, amphotericin B, polymyxin, platinum complexes)\n* Immune-related kidney disease or on hormone therapy (e.g. lupus nephritis, IgA nephropathy)\n* Planned exposure to contrast within 72 h after the procedure, intravascular administration of contrast within the previous 5 days\n* Intake of anticoagulants\n* Hemoglobin \\\u003C60 g\u002FL\n* Severe valvular disease or valvular disease likely to require surgery or percutaneous valve replacement during the trial\n* Patients allergic to metals or contrast","ALL","18 Years",{"count":75,"type":76},1528,"ESTIMATED","INTERVENTIONAL",[79],"NA","The IVUS-CKD study is a prospective, randomized controlled, multicenter trial to determine whether the intravascular ultrasound (IVUS)-guided percutaneous coronary intervention is superior to the angiography-guidance in chronic kidney disease (CKD) patients with respect to target vessel failure (TVF) at 12 months after randomization.",[82,83],"Coronary Artery Disease","Chronic Kidney Diseases",[82,85,86,87,88],"Chronic Kidney Disease","Percutaneous Coronary Intervention","Intravascular Ultrasound","Randomized Trial","2024-08-21",{"date":91,"type":92},"2024-08-23","ACTUAL",{"date":94,"type":92},"2024-07-25",{"date":96,"type":76},"2027-12",{"name":5,"class":6},1]