[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629535":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":29,"centralContacts":33,"locations":39,"responsibleParty":55,"collaborators":10,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":10,"eligibilityCriteria":63,"healthyVolunteers":59,"sex":64,"minAge":65,"maxAge":10,"enrollmentInfo":66,"targetDuration":69,"studyType":70,"phases":10,"briefSummary":71,"conditions":72,"keywords":10,"overallStatus":75,"whyStopped":10,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"First Affiliated Hospital of Guangxi Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group",null,"Standard medical treatment",[13],"Other: Standard medical care",{"label":15,"type":10,"description":16,"interventionNames":17},"Tenecteplase group","Intravenous tenecteplase thrombolysis",[18,13],"Drug: Tenecteplase (TNK) (0.25 mg\u002Fkg, to maximum of 25mg)",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"DRUG","Tenecteplase (TNK) (0.25 mg\u002Fkg, to maximum of 25mg)","Tenecteplase is administered as a single intravenous bolus at a dose of 0.25 mg\u002Fkg, with a maximum of 25 mg.",[15],{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Standard medical care","Standard medical treatment should adhere to clinical guidelines and usual care at site, including antiplatelet therapy, anticoagulant therapy, lipid-lowering therapy, antihypertensive drugs, etc., as determined by the local investigators.",[9,15],[30],{"name":31,"affiliation":5,"role":32},"Yuan Wu, MD, PhD","PRINCIPAL_INVESTIGATOR",[34],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},"Dong Pan, MD, PhD","CONTACT","86-156 2648 3251","dongpan012@hotmail.com",[40],{"facility":41,"status":10,"city":42,"state":43,"zip":44,"country":45,"countryCode":46,"cosmosGeoPoint":47,"geoPoint":52,"contacts":53},"The First Affiliated Hospital of Guangxi Medical University","Nanning","Guangxi","530021","China","CN",{"type":48,"coordinates":49},"Point",[50,51],108.31667,22.81667,{"lat":51,"lon":50},[54],{"name":35,"role":36,"phone":37,"phoneExt":10,"email":38},{"type":56,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100629535","intravenous-tenecteplase-in-very-old-patients-with-acute-ischemic-stroke-100629535",false,"NCT07475936","Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke","A Multicenter, Prospective, Observational, Real-World Registry Study of Intravenous Tenecteplase in Very Old Patients With Acute Ischemic Stroke","Inclusion Criteria:\n\n1. Age \\> 80 years;\n2. Clinically diagnosed with acute ischemic stroke and arrived at the hospital within 4.5 hours of symptom onset;\n3. Informed consent signed by the patient or legally authorized representative.\n\nExclusion Criteria:\n\n1. Any contraindication to intravenous thrombolysis (excluding age);\n2. Previous treatment with other thrombolytic agents such as alteplase, urokinase, plasminogen activator, or reteplase;\n3. Current participation in other interventional studies;\n4. The investigator deems the patient unsuitable for this study or the study might pose significant risk to the patient (e.g., due to psychiatric disorders, cognitive or emotional impairments that prevent understanding or adherence to study procedures and\u002For follow-up).","ALL","80 Years",{"count":67,"type":68},392,"ESTIMATED","90 Days","OBSERVATIONAL","The benefit of intravenous tenecteplase in very old patients with acute ischemic stroke (AIS) remain uncertain. This real-world study aims to evaluate the effectiveness and safety of intravenous tenecteplase in AIS patients aged 80 years or older within 4.5 hours of symptom onset.",[73,74],"Acute Ischemic Stroke","Tenecteplase","NOT_YET_RECRUITING","2026-03-13",{"date":78,"type":79},"2026-03-17","ACTUAL",{"date":81,"type":68},"2026-04",{"date":83,"type":68},"2027-12",{"name":5,"class":6},1]