[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100385267":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":35,"responsibleParty":52,"collaborators":19,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":19,"eligibilityCriteria":61,"healthyVolunteers":57,"sex":62,"minAge":63,"maxAge":64,"enrollmentInfo":65,"targetDuration":19,"studyType":68,"phases":69,"briefSummary":71,"conditions":72,"keywords":19,"overallStatus":38,"whyStopped":19,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Centre Hospitalier Universitaire Vaudois","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Autologous Chondrocyte Injection","EXPERIMENTAL","Autologous chondrocytes were isolated and expanded in laboratory, then injected at 2x10\\^6 of cells per cm\\^2 of the cartilage defect.",[13],"Other: autologous chondrocytes",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"autologous chondrocytes","autologous chondrocytes implantation (ACI)",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Robin MARTIN, MD","CHUV","PRINCIPAL_INVESTIGATOR",[26,31],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":30},"CONTACT","021 314 76 79","41","robin.martin@chuv.ch",{"name":32,"role":27,"phone":33,"phoneExt":29,"email":34},"Virginie PHILIPPE, Ph-D","021 314 90 18","virginie.philippe@chuv.ch",[36],{"facility":37,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"Centre Hospitalier Universitaire Vaudois - CHUV","RECRUITING","Lausanne","Canton of Vaud","1011","Switzerland","CH",{"type":45,"coordinates":46},"Point",[47,48],6.63282,46.516,{"lat":48,"lon":47},[51],{"name":22,"role":27,"phone":28,"phoneExt":29,"email":30},{"type":24,"investigatorFullName":53,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Dr. Robin Martin","Principal Investigator","100385267","introduction-of-aci-for-cartilage-repair-100385267",false,"NCT04296487","Introduction of ACI for Cartilage Repair","Introduction of Autologous Chondrocyte Implantation Procedure for the Treatment of Chondral Defect in the Knee","Inclusion Criteria:\n\n1. Age between 15 and 50.\n2. Lesions classified as ICRS Grade III or IV and smaller than 15 cm2\n3. Lesions that have failed prior therapy (conservative or surgical treatment ≥ six months)\n4. Subjects who understand and sign the consent form for this study\n\nExclusion Criteria:\n\n1. Body mass index (BMI) of 35 or more\n2. Osteoarthritis or rheumatoid arthritis\n3. Diffuse lesion\n4. Uncorrected mal-alignment, ligamentous instability, or meniscal tear\n5. Presence of growth cartilage (15-18 years old)\n6. Active smoking or drug consumption\n7. Women who are pregnant\n8. Positive serology for HIV-1 or HIV-2, Hepatitis B and C and syphilis\n9. Proven allergy to porcine collagen, penicillin and gentamicin\n10. Poor compliance","ALL","15 Years","50 Years",{"count":66,"type":67},218,"ESTIMATED","INTERVENTIONAL",[70],"NA","This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.",[73,74,75],"Articular Cartilage Defect","Chondral Defect","Osteochondritis","2026-03-10",{"date":78,"type":79},"2026-03-11","ACTUAL",{"date":81,"type":79},"2017-09-01",{"date":83,"type":67},"2030-09",{"name":5,"class":6},1]