[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100542251":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":22,"centralContacts":27,"locations":37,"responsibleParty":52,"collaborators":22,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":22,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":22,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":22,"overallStatus":39,"whyStopped":22,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Aalborg University","OTHER",[8,13],{"label":9,"type":6,"description":10,"interventionNames":11},"Histamine application","In the first session, the subjects will fill some questionnaires. After that, a squared area of 4x4 cm will be selected at the center of each middle forearm of the subject and cowage or histamine will be applied for 10 minutes, during which the pain\u002Fitch following the cowhage\u002Fhistamine application will be monitored with a VAS scale. After the itch-induction, the subjects will fill in other questionnaire. In second session, the subjects will fill some questionnaires. After that, a squared area of 4x4 cm will be selected at the center of each middle forearm of the subject and cowage or histamine will be applied for 10 minutes, during which the pain\u002Fitch following the cowhage\u002Fhistamine application will be monitored with a VAS scale. After the itch-induction, the subjects will fill out other questionnaires. The order will be randomized, so if the subjects were given the cowhage in the first session, they will receive the histamine application in the second session, and vice versa.",[12],"Other: Histamine",{"label":14,"type":6,"description":10,"interventionNames":15},"Cowhage application",[16],"Other: Cowhage",[18,23],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"Histamine","Histaminergic itch will be evoked by a 1% histamine solution. A droplet of histamine solution will be placed on the predetermined area on the forearm, and the SPT lancet will be pierced through the histamine with 120 g of pressure for 1-2 seconds.",[9],null,{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Cowhage","25 spicules will be inserted in the center of the predefined skin area on the mandibular area. The spicules will be gently rubbed for 15-20 seconds in circular motion to facilitate epidermal penetration.",[14],[28,33],{"name":29,"role":30,"phone":31,"phoneExt":22,"email":32},"Silvia Lo Vecchio, PhD","CONTACT","+4521397785","slv@hst.aau.dk",{"name":34,"role":30,"phone":35,"phoneExt":22,"email":36},"Giulia Erica Aliotta, PhD","50290580","gea@hst.aau.dk",[38],{"facility":5,"status":39,"city":40,"state":22,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Aalborg","9620","Denmark","DK",{"type":45,"coordinates":46},"Point",[47,48],9.9187,57.048,{"lat":48,"lon":47},[51],{"name":29,"role":30,"phone":22,"phoneExt":22,"email":22},{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"PRINCIPAL_INVESTIGATOR","Silvia Lo Vecchio","Associate Professor","100542251","investigate-the-relationship-between-catastrophizing-and-the-perception-of-itch-intensity-in-healthy-individuals-100542251",false,"NCT06340438","Investigate the Relationship Between Catastrophizing and the Perception of Itch Intensity in Healthy Individuals","Investigation of the Neurophysiological and Psychological Aspects of Itch","Inclusion Criteria:\n\n* Healthy men and women\n* 18-60 years\n* Speak and understand English\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Drug addiction defined as any use of cannabis, opioids, or other addictive drugs\n* Previous or current history of neurological (e.g. neuropathy), immunological (e.g. asthma, immune deficiencies, arthritis), musculoskeletal (e.g. muscular pain in the upper extremities,), cardiac disorder, or mental illnesses that may affect the results\n* Lack of ability to cooperate\n* Current use of medications that may affect the trial such as antihistamines, antipsychotics, and pain killers, as well as systemic or topical steroids\n* Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)\n* Moles, scars, or tattoos in the area to be treated or tested.\n* Consumption of alcohol or painkillers 24 hours before the study days and between these\n* Acute or chronic pain\n* Participation in other trials within one week of study entry (four weeks in the case of pharmaceutical trials)",true,"ALL","18 Years","60 Years",{"count":68,"type":69},46,"ESTIMATED","INTERVENTIONAL",[72],"NA","This project aims to investigate the relationship between different dimensions of catastrophizing (rumination, magnification, and helplessness) as well as some specific personality traits related to catastrophizing tendencies like anxiety sensitivity and fear sensitivity in the modulation of itch and pain intensities in an experimental setting.",[19,24],"2024-06-19",{"date":77,"type":78},"2024-06-24","ACTUAL",{"date":80,"type":78},"2024-04-27",{"date":82,"type":69},"2026-12-31",{"name":5,"class":6},1]