[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633983":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":24,"centralContacts":29,"locations":35,"responsibleParty":53,"collaborators":24,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":24,"eligibilityCriteria":62,"healthyVolunteers":63,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":24,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":79,"whyStopped":24,"lastUpdateSubmitDate":80,"lastUpdatePostDateStruct":81,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":89},{"fullName":5,"class":6},"The Second Hospital of Anhui Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"ECT group","ACTIVE_COMPARATOR","The patient will undergo at least three sessions of electroconvulsive therapy (ECT).",[13],"Other: Electroconvulsive Therapy",{"label":15,"type":10,"description":16,"interventionNames":17},"MST group","The patient will undergo at least three sessions of magnetic seizure therapy (MST).",[18],"Other: Magnetic Seizure Therapy",[20,25],{"type":6,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"Electroconvulsive Therapy","Electroconvulsive therapy will be administered 2 to 3 times per week according to a standardized protocol. Stimulation parameters-including intensity, target site, number of sessions, and duration-will be individually tailored for each participant based on prior research to ensure targeted and safe delivery within established safety parameters. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.",[9],null,{"type":6,"name":26,"description":27,"armGroupLabels":28,"otherNames":24},"Magnetic Seizure Therapy","Magnetic seizure therapy will be administered 2 to 3 times per week according to a standardized protocol. Stimulation parameters-including intensity, target location, number of sessions, and duration-will be individually tailored for each participant based on prior research to ensure targeted and safe delivery within established safety parameters. Treatment will continue until the participant meets the protocol-defined response criteria or completes a maximum of 10 sessions.",[15],[30],{"name":31,"role":32,"phone":33,"phoneExt":24,"email":34},"Yanghua Tian","CONTACT","+86-13955188448","tianyh@ahmu.edu.cn",[36],{"facility":37,"status":24,"city":38,"state":39,"zip":24,"country":40,"countryCode":41,"cosmosGeoPoint":42,"geoPoint":47,"contacts":48},"The Second Affiliated Hospital of Anhui Medical University","Hefei","Anhui","China","CN",{"type":43,"coordinates":44},"Point",[45,46],117.28083,31.86389,{"lat":46,"lon":45},[49],{"name":50,"role":32,"phone":51,"phoneExt":24,"email":52},"Nanxue Duan","+86-18326962052","2345011356@stu.ahmu.edu.cn",{"type":54,"investigatorFullName":31,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"PRINCIPAL_INVESTIGATOR","President of the First Affiliated Hospital of the University of Science and Technology of China","100633983","investigating-functional-changes-in-the-frontotemporal-cortex-of-patients-with-major-depressive-disorder-following-electroconvulsive-therapy-or-magnetic-seizure-therapy-using-functional-near-infrared-spectroscopy-fnirs-100633983",false,"NCT07533773","Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS)","Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy","Inclusion Criteria:\n\n* A depressive episode diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed by two psychiatrists;\n* Meets the treatment criteria for ECT or MST;\n* At least 5 years of education, with no significant hearing or visual impairments;\n* Voluntary participation in this study, with a signed written informed consent form, and willingness to cooperate with the collection of general demographic information, neuropsychological testing, and fNIRS resting-state and task-based data acquisition.\n\nExclusion Criteria:\n\n* Co-occurring mental disorders (such as substance use disorders or schizoaffective disorder);\n* Severe physical illness;\n* History of neurological disorders (such as traumatic brain injury or dementia);\n* Low educational attainment;\n* Receipt of ECT or MST treatment within the past six months.",true,"ALL","12 Years","65 Years",{"count":68,"type":69},60,"ESTIMATED","INTERVENTIONAL",[72],"NA","Against the clinical backdrop of the growing global burden of neuropsychiatric disorders, the rapid rise in depression prevalence, and the frequent association of these conditions with cognitive impairment, this study highlights the limitations of current cognitive assessment tools-such as their time-consuming nature and lack of specificity-and underscores the urgent need to develop simple and efficient assessment methods. In terms of treatment, modified electroconvulsive therapy (ECT) and magnetic seizure therapy (MST) are rapidly acting neuromodulation therapies; however, their effects on cognitive function and underlying brain mechanisms remain controversial, and there is a lack of direct comparative studies. Functional near-infrared spectroscopy (fNIRS) technology can non-invasively monitor changes in cerebral hemodynamics, providing a powerful tool for assessing brain function before and after treatment. Therefore, this study aims to combine resting-state and task-based fNIRS with multidimensional cognitive and emotional assessments to systematically compare the effects of ECT and MST on frontal-temporal cerebral hemodynamics. We seek to clarify the differences in brain function regulation between the two treatment modalities and their association with improvements in cognition and mood, with the goal of providing scientific evidence to elucidate the brain mechanisms underlying neurostimulation therapies and optimize individualized treatment plans.",[75],"Major Depressive Disorder (MDD)",[77,21,26,78],"Major Depressive Disorder","Functional Near-Infrared Spectroscopy","NOT_YET_RECRUITING","2026-04-09",{"date":82,"type":83},"2026-04-16","ACTUAL",{"date":85,"type":69},"2026-04-30",{"date":87,"type":69},"2029-04-30",{"name":5,"class":6},1]