[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100609674":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":19,"centralContacts":20,"locations":26,"responsibleParty":43,"collaborators":19,"id":47,"slug":48,"hasResults":49,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":19,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":54,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":19,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":29,"whyStopped":19,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":80},{"fullName":5,"class":6},"University of Iowa","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Within subject manipulation of working memory, cognitive control, and decision making","EXPERIMENTAL","Participants will complete a series of cognitive tasks designed to engage working memory, cognitive control, and decision-making. During these tasks, participants will view stimuli and make rule-based or value-based choices that require updating and applying context to guide behavior. Brain activity will be measured using high-resolution 7-Tesla functional MRI to assess how the mediodorsal thalamus and prefrontal cortex represent and update contextual information. Computational models will link behavior and neural activity to test how thalamic signals support flexible cognition and adaptive decision-making.",[13],"Other: High-resolution fMRI during working memory, cognitive control, and decision-making tasks",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":19},"High-resolution fMRI during working memory, cognitive control, and decision-making tasks","Participants will perform a set of computerized cognitive tasks designed to test working memory, cognitive control, and decision-making while undergoing high-resolution 7-Tesla functional MRI. These tasks require participants to maintain and update contextual information, switch between rules, and make value-based choices under changing conditions. The intervention is distinguished by its integration of advanced neuroimaging with computational modeling to identify how the mediodorsal thalamus and prefrontal cortex represent, update, and generalize context. This approach allows precise mapping of thalamocortical mechanisms that support flexible cognition and goal-directed behavior.",[9],null,[21],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},"Kai Hwang, PhD","CONTACT","319-335-2406","kai-hwang@uiowa.edu",[27],{"facility":28,"status":29,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":41},"The University of Iowa","RECRUITING","Iowa City","Iowa","52242","United States","US",{"type":36,"coordinates":37},"Point",[38,39],-91.53017,41.66113,{"lat":39,"lon":38},[42],{"name":22,"role":23,"phone":24,"phoneExt":19,"email":25},{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"SPONSOR_INVESTIGATOR","Kai Hwang","Associate Professor","100609674","investigating-mediodorsal-thalamus-representations-underlying-human-cognitive-flexibility-100609674",false,"NCT07217652","Investigating Mediodorsal Thalamus Representations Underlying Human Cognitive Flexibility","Inclusion Criteria:\n\n* No history of any neurological, psychiatric, or medical condition that could affect cognition\n* No use of benzodiazepines, long-acting opioids, or other psychotropic drugs that could alter cognitive performance\n* Normal or corrected-to-normal vision (visual acuity)\n* Normal color perception (Farnsworth-Munsell 100 Hue Test)\n* Fluent in English\n* No metal implants (including aneurysm clip, cardiac pacemaker, ICD, IUD, neurostimulation system, spinal cord stimulator, internal electrodes or wires, bone stimulator, ear implant, insulin or other infusion pump or device, prosthesis, artificial or prosthetic limb, shunt, vascular access port or catheter, thermodilution catheter, medication patch, radiation seeds or implants, wire mesh implant, tissue expander, surgical staples or clips or sutures, joint replacement, joint\u002Fbone pin\u002Fscrew\u002Fnail\u002Fwire\u002Fplate, dentures, or non-removable hearing aid)\n* No exposure to shrapnel or other-related MR contraindications\n* No non-removable body piercing jewelry\n* No non-removable makeup\n* No history of claustrophobia\n* No history of breathing problems\n* Not currently pregnant or trying to get pregnant (this will be determined via self report and no records will be kept).\n\nExclusion Criteria:\n\n* Has a history of any neurological, psychiatric, or medical condition that could affect cognition\n* Use of benzodiazepines, long-acting opioids, or other psychotropic drugs that could alter cognitive performance\n* Not fluent in English\n* Known metal implants (including aneurysm clip, cardiac pacemaker, ICD, IUD, neurostimulation system, spinal cord stimulator, internal electrodes or wires, bone stimulator, ear implant, insulin or other infusion pump or device, prosthesis, artificial or prosthetic limb, shunt, vascular access port or catheter, thermodilution catheter, medication patch, radiation seeds or implants, wire mesh implant, tissue expander, surgical staples or clips or sutures, joint replacement, joint\u002Fbone pin\u002Fscrew\u002Fnail\u002Fwire\u002Fplate, dentures, or non-removable hearing aid)\n* History of claustrophobia\n* Currently pregnant or trying to get pregnant (this will be determined via self report and no records will be kept).",true,"ALL","18 Years","35 Years",{"count":58,"type":59},100,"ESTIMATED","INTERVENTIONAL",[62],"NA","The goal of this basic experimental research study is to examine how the human thalamus supports flexible thinking and behavior. Specifically, the research aims to elucidate how the mediodorsal (MD) thalamus encodes and updates \"context\"-the mental framework that determines which rules or actions are relevant in a given situation. This work may contribute to understanding why certain psychiatric conditions, such as schizophrenia and ADHD, involve difficulties with cognitive flexibility and control.\n\nThe primary research questions are:\n\nDoes the MD thalamus represent the context that organizes how working memory guides task selection? Does the MD thalamus signal when context needs to be updated after a change in task demands? Do these thalamic representations support generalization to new situations or rules?\n\nParticipants will complete cognitive tasks while undergoing high-resolution brain imaging using 7-Tesla MRI. The investigators will combine behavioral data, computational modeling, and advanced neuroimaging analyses to examine how the thalamus interacts with the cortex during flexible decision-making.",[65,66],"Schizophrenia","Attention Deficit Disorder With Hyperactivity (ADHD)",[68,69,70],"Cognitive control","working memory","decision making","2026-02-10",{"date":73,"type":74},"2026-02-13","ACTUAL",{"date":76,"type":74},"2025-12-01",{"date":78,"type":59},"2030-07-30",{"name":45,"class":6},1]