[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100502270":3},{"organization":4,"armGroups":7,"interventions":24,"overallOfficials":45,"centralContacts":50,"locations":58,"responsibleParty":81,"collaborators":83,"id":89,"slug":90,"hasResults":91,"nctId":92,"briefTitle":93,"officialTitle":93,"acronym":10,"eligibilityCriteria":94,"healthyVolunteers":95,"sex":96,"minAge":97,"maxAge":10,"enrollmentInfo":98,"targetDuration":10,"studyType":101,"phases":10,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":61,"whyStopped":10,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":116,"completionDateStruct":118,"leadSponsor":120,"locationsCount":121},{"fullName":5,"class":6},"Swiss Federal Institute of Technology","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Young, healthy control",null,"Young healthy participants below 45 years will take part in a gait protocol involving treadmill walking with pertubations and overground walking including obstacle stepping, figure-8-walk and timed-up-and-go test, as well as a seated-stepping section.\n\nDuring the protocol, neural activity is recorded using EEG.",[13,14],"Diagnostic Test: Neural Activity Recording","Diagnostic Test: Movement Parameter Recording",{"label":16,"type":10,"description":17,"interventionNames":18},"Age-matched healthy control","Age-matched healthy participants above 45 years will take part in a gait protocol involving treadmill walking with pertubations and overground walking including obstacle stepping, figure-8-walk and timed-up-and-go test, as well as a seated-stepping section.\n\nDuring the protocol, neural activity is recorded using EEG.",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Parkinson's patients","Parkinson's patients will take part in a gait protocol involving treadmill walking with pertubations and overground walking including obstacle stepping, figure-8-walk and timed-up-and-go test, as well as a seated-stepping section. Additionally, a neuromodulation set-up will be tested.\n\nDuring the protocol, neural activity is recorded using EEG and signals from the DBS-electrodes.",[13,14,23],"Other: Neuromodulation",[25,33,41],{"type":26,"name":27,"description":28,"armGroupLabels":29,"otherNames":30},"DIAGNOSTIC_TEST","Neural Activity Recording","Neural Activity is measured using EEG in all groups. Additionally, in Parkinson's patients, local-field-potentials from deep brain stimulation electrodes are recorded.",[16,20,9],[31,32],"Electroencephalography (EEG)","Local-Field-Potentials with deep brain stimulation electrodes",{"type":26,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Movement Parameter Recording","Gait-related movement parameters are non-invasively recorded using motion capture, accelerometers and electromyography.",[16,20,9],[38,39,40],"Motion capture","Accelerometers","Electromyography",{"type":6,"name":42,"description":43,"armGroupLabels":44,"otherNames":10},"Neuromodulation","Neural signals are recorded with the electrodes of the deep brain stimulation device. Parkinson's patients are asked to modulate their neural activity by observing the streamed neural activity and applying mental strategies.",[20],[46],{"name":47,"affiliation":48,"role":49},"Olivier Lambercy, PhD","RELab, ETH Zürich","PRINCIPAL_INVESTIGATOR",[51,56],{"name":52,"role":53,"phone":54,"phoneExt":10,"email":55},"Lena Salzmann, MSc","CONTACT","+41788248679","lena.salzmann@hest.ethz.ch",{"name":47,"role":53,"phone":10,"phoneExt":10,"email":57},"oliver.lambercy@hest.ethz.ch",[59],{"facility":60,"status":61,"city":62,"state":63,"zip":64,"country":65,"countryCode":66,"cosmosGeoPoint":67,"geoPoint":72,"contacts":73},"Cereneo","RECRUITING","Vitznau","Canton of Lucerne","6354","Switzerland","CH",{"type":68,"coordinates":69},"Point",[70,71],8.4842,47.01014,{"lat":71,"lon":70},[74,78],{"name":75,"role":53,"phone":76,"phoneExt":10,"email":77},"Andreas Luft, Professor","+41 44 255 55 11","andreas.luft@usz.ch",{"name":79,"role":53,"phone":80,"phoneExt":10,"email":55},"Lena Salzmann, PhD student","+41 44 510 72 34",{"type":82,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR",[84,87],{"name":85,"class":86},"cereneo center for Neurology and Rehabilitation","UNKNOWN",{"name":88,"class":6},"University of Zurich","100502270","investigating-neural-biomarkers-for-gait-in-parkinsons-patients-100502270",false,"NCT05820074","Investigating Neural Biomarkers for Gait in Parkinson's Patients","Inclusion Criteria:\n\nAll participants\n\n* must have given informed consent as documented by signature\n* agree to comply with the study procedures\n\nHealthy control group\n\n* no neurological, orthopedic, or rheumatologic disease history\n* no identified sensory impairment.\n* no epilepsy and self-diagnosed acute or chronic psychiatric disorders\n\nParkinson's Patients\n\n* non-tremor dominant idiopathic PD patients\n* presence of postural instability (UPDRS \\>1 for postural instability \\[17\\]), gait disturbance, and absence of other causes of reduced balance\n* Implanted with Percept™ PC neurostimulator\n* Able to be in the stimulation OFF\n\nExclusion Criteria:\n\n* Relevant cognitive impairment, with a score on Montréal Cognitive Assessment (MoCA) \\\u003C 20\n* History of physical or neurological condition that interferes with study procedures\n* Social and\u002For personal circumstances interfering with the ability to come to the session",true,"ALL","18 Years",{"count":99,"type":100},60,"ESTIMATED","OBSERVATIONAL","This observational study's main goal is to learn more about the neural mechanisms during movement in Parkinson's disease. Furthermore, it aims to inspire personalised treatment options.\n\nParticipants will undergo a protocol that involves walking and gait-related motor tasks, such as seated stepping. During the protocol, brain activity will be recorded.",[104,105],"Parkinson Disease","Gait Disorders, Neurologic",[107,108,109,110,111],"Parkinson's disease","gait parameters","neural activity","Percept PC","deep brain stimulation","2024-11-28",{"date":114,"type":115},"2024-12-03","ACTUAL",{"date":117,"type":115},"2023-04-13",{"date":119,"type":100},"2025-03",{"name":5,"class":6},1]